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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O75311
No. Gene UniProt ID Protein Name Pathway PDB
1 GLRA3 O75311 Glycine receptor subunit alpha-3 hsa04080 5CFB


8 known interactions (drugs) of input target (GLRA3): Glycine receptor subunit alpha-3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb
2 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
3 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
5 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb
7 Experimental SmallMoleculeDrug DB00466 Picrotoxin Thumb
8 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00602 Ivermectin Thumb


20 predicted interactions (drugs) of input target (GLRA3): Glycine receptor subunit alpha-3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb 55.2%
2 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 43.7%
3 Approved;
Investigational		 SmallMoleculeDrug DB11582 Thiocolchicoside Thumb 43.5%
4 Investigational SmallMoleculeDrug DB05885 Seletracetam Thumb 42.9%
5 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 42.8%
6 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 42.7%
7 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb 41.0%
8 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb 40.8%
9 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb 40.7%
10 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 40.6%
11 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb 40.5%
12 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb 39.4%
13 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb 38.8%
14 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 38.6%
15 Approved;
Investigational		 SmallMoleculeDrug DB01174 Phenobarbital Thumb 38.3%
16 Approved;
Vet approved		 SmallMoleculeDrug DB00599 Thiopental Thumb 37.9%
17 Investigational SmallMoleculeDrug DB12458 Muscimol Thumb 36.4%
18 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00475 Chlordiazepoxide Thumb 36.2%
19 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 36.0%
20 Approved;
Vet approved		 SmallMoleculeDrug DB00794 Primidone Thumb 35.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.