QuartataWeb 1.0

57 known interactions (drugs) of input target (PTPN1): Tyrosine-protein phosphatase non-receptor type 1

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Experimental	SmallMoleculeDrug	DB04204	[(4-{4-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Butyl}-Phenyl)-Difluoro-Methyl]-Phosphonic Acid	OP(O)(=O)C(F)(F)C1=CC=C(CCCCC2=CC=C(C=C2)C(F)(F)P(O)(O)=O)C=C1
2	Experimental	SmallMoleculeDrug	DB08003	ISOTHIAZOLIDINONE ANALOG	[H][C@@](CC1=CC=C(C=C1)[C@]1([H])CC(=O)NS1(=O)=O)(NC(=O)[C@]([H])(CC1=CC=CC=C1)NC(C)=O)C(N)=O
3	Investigational	SmallMoleculeDrug	DB06521	Ertiprotafib	CC1=C(C)C2=C(C3=CC(C)=C(O[C@H](CC4=CC=CC=C4)C(O)=O)C(C)=C3)C3=CC=CC=C3C(Br)=C2S1
4	Experimental	SmallMoleculeDrug	DB03483	4-Benzoylamino-4-{1-{1-Carbamoyl-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethylcarbamoyl}-Butyric Acid	[H][C@@](CCC(O)=O)(N=C(O)C1=CC=CC=C1)C(O)=N[C@@]([H])(CC1=CC=C(C=C1)C(F)(F)P(O)(O)=O)C(O)=N[C@@]([H])(CC1=CC=C(C=C1)C(F)(F)P(O)(O)=O)C(O)=N
5	Experimental	SmallMoleculeDrug	DB07651	N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE	[H][C@@](CC1=CC=C(C=C1)C(F)(F)P(O)(O)=O)(NC(=O)[C@]([H])(CC1=CC=CC=C1)NC(C)=O)C(N)=O
6	Experimental	SmallMoleculeDrug	DB04285	{4-[(2s,4e)-2-(1,3-Benzothiazol-2-Yl)-2-(1h-1,2,3-Benzotriazol-1-Yl)-5-Phenylpent-4-Enyl]Phenyl}(Difluoro)Methylphosphonic Acid	[H]\C(C[C@](CC1=CC=C(C=C1)C(F)(F)P(O)(O)=O)(N1N=NC2=CC=CC=C12)C1=NC2=CC=CC=C2S1)=C(\[H])C1=CC=CC=C1
7	Experimental	SmallMoleculeDrug	DB02615	Compound 19	[H][C@@](C)(COC1=CC=C(C=C1)[C@]1([H])OC2=C(S[C@]1([H])C1=CC=C(O)C=C1)C=C(O)C=C2)N1CCCC1
8	Experimental	SmallMoleculeDrug	DB03982	Compound 5, 2-(Naphthalen-1-Yl-Oxalyl-Amino)-Benzoicacid	OC(=O)C(=O)N(C1=CC=CC=C1C(O)=O)C1=CC=CC2=C1C=CC=C2
9	Experimental	SmallMoleculeDrug	DB07719	[(3R)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid	[H]N(C)C(=O)[C@H]1CC2=C(CN1C(=O)OC(C)(C)C)C=C(C=C2)N([H])S(O)(=O)=O
10	Experimental	SmallMoleculeDrug	DB02620	Sp7343-Sp7964	[H][C@@]1(CC[C@]([H])(CC1)C(O)=NCCSSCCN=C(C)O)N=C(O)C1=C(N=CC=N1)C(O)=O
11	Experimental	SmallMoleculeDrug	DB02436	2-{4-[(2s)-2-[({[(1s)-1-Carboxy-2-Phenylethyl]Amino}Carbonyl)Amino]-3-Oxo-3-(Pentylamino)Propyl]Phenoxy}Malonic Acid	[H][C@@](CC1=CC=CC=C1)(NC(O)=N[C@@]([H])(CC1=CC=C(OC(C(O)=O)C(O)=O)C=C1)C(O)=NCCCCC)C(O)=O
12	Experimental	SmallMoleculeDrug	DB07298	3-(CARBOXYMETHOXY)THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID	OC(=O)COC1=C(SC2=NC=CC=C12)C(O)=O
13	Experimental	SmallMoleculeDrug	DB02014	Compound 9	COC(=O)C1=C(O)C=CC=C1OC\C=C\C1=CC(C2=CC(=NO2)C(O)=O)=C(F)C=C1
14	Experimental	SmallMoleculeDrug	DB02651	{[2-(1h-1,2,3-Benzotriazol-1-Yl)-2-(3,4-Difluorophenyl)Propane-1,3-Diyl]Bis[4,1-Phenylene(Difluoromethylene)]}Bis(Phosphonic Acid)	OP(O)(=O)C(F)(F)C1=CC=C(CC(CC2=CC=C(C=C2)C(F)(F)P(O)(O)=O)(N2N=NC3=C2C=CC=C3)C2=CC=C(F)C(F)=C2)C=C1
15	Experimental	SmallMoleculeDrug	DB08397	6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID	OC(=O)C1=CC2=C(C=C1)C=C(C=C2)C(F)(F)P(O)(O)=O
16	Experimental	SmallMoleculeDrug	DB07263	[{2-bromo-4-[(2R)-3-oxo-2,3-diphenylpropyl]phenyl}(difluoro)methyl]phosphonic acid	[H][C@](CC1=CC(Br)=C(C=C1)C(F)(F)P(O)(O)=O)(C(=O)C1=CC=CC=C1)C1=CC=CC=C1
17	Experimental	SmallMoleculeDrug	DB07289	5-[3-(BENZYLAMINO)PHENYL]-4-BROMO-3-(CARBOXYMETHOXY)THIOPHENE-2-CARBOXYLIC ACID	OC(=O)COC1=C(SC(=C1Br)C1=CC=CC(NCC2=CC=CC=C2)=C1)C(O)=O
18	Experimental	SmallMoleculeDrug	DB02977	PNU177836	[H][C@@](O)(N[C@@]([H])(CC1=CC=CC=C1)[C@]([H])(O)N[C@@]([H])(CC1=CC(C(O)=O)=C(OCC(O)=O)C=C1)[C@@]([H])(O)NCCCCC)OC(C)(C)C
19	Experimental	SmallMoleculeDrug	DB03154	{[7-(Difluoro-Phosphono-Methyl)-Naphthalen-2-Yl]-Difluoro-Methyl}-Phosphonic Acid	OP(O)(=O)C(F)(F)C1=CC2=CC(=CC=C2C=C1)C(F)(F)P(O)(O)=O
20	Experimental	SmallMoleculeDrug	DB08371	PARA-(BENZOYL)-PHENYLALANINE	[H][C@](N)(CC1=CC=C(C=C1)C(=O)C1=CC=CC=C1)C(O)=O
21	Experimental	SmallMoleculeDrug	DB02259	3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid (4-Sulfamoyl-Phenyl)-Amide	CCC1=C(C(=O)C2=CC(Br)=C(O)C(Br)=C2)C2=C(O1)C=C(C=C2)S(=O)(=O)NC1=CC=C(C=C1)S(N)(=O)=O
22	Experimental	SmallMoleculeDrug	DB04142	3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid Dimethylamide	CCC1=C(C(=O)C2=CC(Br)=C(O)C(Br)=C2)C2=C(O1)C=C(C=C2)S(=O)(=O)N(C)C
23	Experimental	SmallMoleculeDrug	DB08147	4-[3-(dibenzylamino)phenyl]-2,4-dioxobutanoic acid	OC(=O)C(=O)CC(=O)C1=CC=CC(=C1)N(CC1=CC=CC=C1)CC1=CC=CC=C1
24	Experimental	SmallMoleculeDrug	DB04001	6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid	OC(=O)C(=O)NC1=CC2=C(C=CN2)C=C1C(O)=O
25	Experimental	SmallMoleculeDrug	DB07295	2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID	OC(=O)C(=O)N(C1=CC=CC=C1C(O)=O)C1=CC=CC2=CC=C(O)C=C12
26	Experimental	SmallMoleculeDrug	DB03311	3-(3,5-Dibromo-4-Hydroxy-Benzoyl)-2-Ethyl-Benzofuran-6-Sulfonic Acid [4-(Thiazol-2-Ylsulfamoyl)-Phenyl]-Amide	CCC1=C(C(=O)C2=CC(Br)=C(O)C(Br)=C2)C2=C(O1)C=C(C=C2)S(=O)(=O)NC1=CC=C(C=C1)S(=O)(=O)NC1=NC=CS1
27	Experimental	SmallMoleculeDrug	DB03670	2-(Oxalyl-Amino)-4,5,6,7-Tetrahydro-Thieno[2,3-C]Pyridine-3-Carboxylic Acid	OC(=O)C(=O)NC1=C(C(O)=O)C2=C(CNCC2)S1
28	Experimental	SmallMoleculeDrug	DB06829	4-BROMO-3-(CARBOXYMETHOXY)-5-[3-(CYCLOHEXYLAMINO)PHENYL]THIOPHENE-2-CARBOXYLIC ACID	OC(=O)COC1=C(SC(=C1Br)C1=CC=CC(NC2CCCCC2)=C1)C(O)=O
29	Experimental	SmallMoleculeDrug	DB04525	2-(Carboxymethoxy)-5-[(2s)-2-({(2s)-2-[(3-Carboxypropanoyl)Amino] -3-Phenylpropanoyl}Amino)-3-Oxo-3-(Pentylamino)Propyl]Benzoic Acid	[H][C@@](CC1=CC=CC=C1)(N=C(O)CCC(O)=O)C(O)=N[C@@]([H])(CC1=CC(C(O)=O)=C(OCC(O)=O)C=C1)C(O)=NCCCCC
30	Investigational	BiotechDrug	DB06333	Trodusquemine	NA
31	Experimental	SmallMoleculeDrug	DB04800	1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID	CN1N=C(C=C1NS(O)(=O)=O)C1=CC=CC=C1
32	Experimental	SmallMoleculeDrug	DB07134	5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE	ClC1=C(SC=C1N1CC(=O)NS1(=O)=O)C1=CC=CC=C1
33	Experimental	SmallMoleculeDrug	DB04088	N-(Allyloxycarbonyl)-4-[N-(Carboxy-Formyl)-2-(Benzoic Acid)-Amino]-L-Phenylalaninyl-Amino-Butyloxy-(6-Hydroxy-Benzoic Acid Methyl Ester)	[H][C@@](CC1=CC=C(C=C1)N(C(=O)C(O)=O)C1=CC=CC=C1C(O)=O)(N=C(O)OCC=C)C(O)=NCCCCOC1=CC=CC(O)=C1C(=O)OC
34	Experimental	SmallMoleculeDrug	DB02662	Novo Nordisk a/S Compound	OC(=O)C(=O)NC1=C(C=C(I)C=C1)C(O)=O
35	Experimental	SmallMoleculeDrug	DB08549	(3R)-METHYLCARBAMOYL-7-SULFOAMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID BENZYL ESTER	[H][C@]1(CC2=C(CN1C(=O)OCC1=CC=CC=C1)C=C(NS(O)(=O)=O)C=C2)C(=O)NC
36	Experimental	SmallMoleculeDrug	DB03102	2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid	OC(=O)C(=O)NC1=C(C(O)=O)C2=C(COCC2)S1
37	Experimental	SmallMoleculeDrug	DB07730	5-(3-HYDROXYPHENYL)ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE	OC1=CC(=CC=C1)C1=CC(=O)NS1(=O)=O
38	Experimental	SmallMoleculeDrug	DB06887	[(3S)-3-(Methylcarbamoyl)-2-{[(2-methyl-2-propanyl)oxy]carbonyl}-1,2,3,4-tetrahydro-7-isoquinolinyl]sulfamic acid	CNC(=O)[C@@H]1CC2=CC=C(NS(O)(=O)=O)C=C2CN1C(=O)OC(C)(C)C
39	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB01133	Tiludronic acid	OP(O)(=O)C(SC1=CC=C(Cl)C=C1)P(O)(O)=O
40	Experimental	SmallMoleculeDrug	DB03714	4-Carbamoyl-4-{[6-(Difluoro-Phosphono-Methyl)-Naphthalene-2-Carbonyl]-Amino}-Butyric Acid	[H][C@@](CCC(O)=O)(NC(=O)C1=CC2=C(C=C1)C=C(C=C2)C(F)(F)P(O)(O)=O)C(N)=O
41	Experimental	SmallMoleculeDrug	DB01820	Compound 12, N-Acetyl-4-[(Carboxycarbonyl)(2-Carboxyphenyl)Amino]-N-Pentyl-1-Napthylalaniamide	[H][C@@](CC1=CC=C(N(C(=O)C(O)=O)C2=CC=CC=C2C(O)=O)C2=CC=CC=C12)(N=C(C)O)C(O)=NCCCCC
42	Investigational	SmallMoleculeDrug	DB05506	ISIS 113715	NA
43	Experimental	SmallMoleculeDrug	DB02784	N-[4-(2-{2-[3-(2-Bromo-Acetylamino)-Propionylamino]-3-Hydroxy-Propionylamino}-Ethyl)-Phenyl]-Oxalamic Acid	[H][C@@](CO)(N=C(O)CCN=C(O)CBr)C(O)=NCCC1=CC=C(C=C1)N=C(O)C(O)=O
44	Experimental	SmallMoleculeDrug	DB08001	5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC ACID	COC(=O)C1=C(O)C=CC=C1OC\C=C\C1=CC(=CC=C1)C1=C(CO)C(=NO1)C(O)=O
45	Experimental	SmallMoleculeDrug	DB08593	1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE	O=C1CN(C2=CC=CC=C2)S(=O)(=O)N1
46	Experimental	SmallMoleculeDrug	DB07130	4-BROMO-3-(CARBOXYMETHOXY)-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID	OC(=O)COC1=C(SC(=C1Br)C1=CC=CC=C1)C(O)=O
47	Experimental	SmallMoleculeDrug	DB02622	2-(Oxalyl-Amino)-Benzoic Acid	OC(=O)C(=O)NC1=C(C=CC=C1)C(O)=O
48	Experimental	SmallMoleculeDrug	DB02827	7-(1,1-Dioxo-1h-Benzo[D]Isothiazol-3-Yloxymethyl)-2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Pyran-3-Carboxylic Acid	[H][C@@]1(COC2=NS(=O)(=O)C3=C2C=CC=C3)OCCC2=C1SC(NC(=O)C(O)=O)=C2C(O)=O
49	Experimental	SmallMoleculeDrug	DB01734	3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid	OC(=O)C(=O)NC1=CC2=C(C=CC=C2)C=C1C(O)=O
50	Experimental	SmallMoleculeDrug	DB03661	Cysteinesulfonic Acid	N[C@@H](CS(O)(=O)=O)C(O)=O
51	Experimental	SmallMoleculeDrug	DB03557	N-{1-[5-(1-Carbamoyl-2-Mercapto-Ethylcarbamoyl)-Pentylcarbamoyl]-2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Ethyl}-3-{2-[4-(Difluoro-Phosphono-Methyl)-Phenyl]-Acetylamino}-Succinamic Acid	[H]C(CS)(N=C(O)CCCCCN=C(O)[C@]([H])(CC1=CC=C(C=C1)C(F)(F)P(O)(O)=O)N=C(O)C([H])(CC(O)=O)N=C(O)CC1=CC=C(C=C1)C(F)(F)P(O)(O)=O)C(O)=N
52	Experimental	SmallMoleculeDrug	DB08591	5-(4-METHOXYBIPHENYL-3-YL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE	COC1=CC=C(C=C1N1CC(=O)NS1(=O)=O)C1=CC=CC=C1
53	Experimental	SmallMoleculeDrug	DB02072	2-(Oxalyl-Amino)-4,7-Dihydro-5h-Thieno[2,3-C]Thiopyran-3-Carboxylic Acid	OC(=O)C(=O)NC1=C(C(O)=O)C2=C(CSCC2)S1
54	Experimental	SmallMoleculeDrug	DB08783	(4-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-methoxy-3-oxopropyl}phenyl)methaneseleninic acid	[H][C@@](CC1=CC=C(C[Se](O)=O)C=C1)(NC(=O)OC(C)(C)C)C(=O)OC
55	Experimental	SmallMoleculeDrug	DB07480	4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN	OP(O)(=O)OC1=CC=C(CC2=CC=C(OP(O)(O)=O)C=C2)C=C1
56	Experimental	SmallMoleculeDrug	DB02420	[[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,	NCC1=CC=C(NC(=O)C(O)=O)C=C1
57	Experimental	SmallMoleculeDrug	DB07197	4-BROMO-3-(CARBOXYMETHOXY)-5-(4-HYDROXYPHENYL)THIOPHENE-2-CARBOXYLIC ACID	OC(=O)COC1=C(SC(=C1Br)C1=CC=C(O)C=C1)C(O)=O

20 predicted interactions (drugs) of input target (PTPN1): Tyrosine-protein phosphatase non-receptor type 1

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Approved	SmallMoleculeDrug	DB02659	Cholic Acid	[H][C@@](C)(CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@]([H])(O)C[C@]4([H])C[C@]([H])(O)CC[C@]4(C)[C@@]3([H])C[C@]([H])(O)[C@]12C	56.7%
2	Approved; Investigational; Nutraceutical	SmallMoleculeDrug	DB00131	Adenosine monophosphate	NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1	52.1%
3	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB01234	Dexamethasone	[H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C	44.6%
4	Experimental; Investigational	SmallMoleculeDrug	DB04216	Quercetin	OC1=CC2=C(C(O)=C1)C(=O)C(O)=C(O2)C1=CC=C(O)C(O)=C1	36.2%
5	Experimental	SmallMoleculeDrug	DB02930	Adenosine 5'-[Î³-thio]triphosphate	[H][C@]1(COP(O)(=O)OP(O)(=O)OP(O)(O)=S)O[C@@]([H])(N2C=NC3=C(N)N=CN=C23)[C@]([H])(O)[C@]1([H])O	36.2%
6	Approved	SmallMoleculeDrug	DB00277	Theophylline	CN1C2=C(NC=N2)C(=O)N(C)C1=O	33.4%
7	Experimental	SmallMoleculeDrug	DB04464	N-Formylmethionine	[H][C@@](CCSC)(NC=O)C(O)=O	32.7%
8	Approved; Investigational	SmallMoleculeDrug	DB08869	Tesamorelin	CC\C=C\CC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O	31.8%
9	Approved; Investigational	SmallMoleculeDrug	DB08813	Nadroparin	NA	31.1%
10	Approved; Nutraceutical	SmallMoleculeDrug	DB00139	Succinic acid	OC(=O)CCC(O)=O	30.8%
11	Approved	SmallMoleculeDrug	DB13269	Dichlorobenzyl alcohol	OCC1=C(Cl)C=C(Cl)C=C1	30.5%
12	Approved; Investigational	SmallMoleculeDrug	DB05541	Brivaracetam	CCC[C@H]1CN([C@@H](CC)C(N)=O)C(=O)C1	30.2%
13	Approved; Experimental; Investigational	SmallMoleculeDrug	DB02709	Resveratrol	OC1=CC=C(\C=C\C2=CC(O)=CC(O)=C2)C=C1	29.8%
14	Experimental	SmallMoleculeDrug	DB04083	N'-Pyridoxyl-Lysine-5'-Monophosphate	[H]\C(=N/CCCC[C@]([H])(N)C(O)=O)C1=C(COP(O)(O)=O)C=NC(C)=C1O	29.4%
15	Experimental	SmallMoleculeDrug	DB07616	4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid	CC1=CC(=CC=C1F)C1=CSC(NC2=CC=C(C(O)=O)C(O)=C2)=N1	28.9%
16	Approved; Investigational	SmallMoleculeDrug	DB09568	Omega-3-carboxylic acids	NA	28.7%
17	Approved; Investigational	SmallMoleculeDrug	DB02530	gamma-Aminobutyric acid	NCCCC(O)=O	28.6%
18	Approved; Investigational	SmallMoleculeDrug	DB07615	Tranilast	COC1=CC=C(\C=C\C(=O)NC2=CC=CC=C2C(O)=O)C=C1OC	28.5%
19	Approved; Investigational	SmallMoleculeDrug	DB09462	Glycerin	OCC(O)CO	28.4%
20	Approved; Investigational	SmallMoleculeDrug	DB03247	Flavin mononucleotide	CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(O)=O)C1=NC(=O)NC(=O)C1=N2	28.4%