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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O76074
No. Gene UniProt ID Protein Name Pathway PDB
1 PDE5A O76074 cGMP-specific 3',5'-cyclic phosphodiesterase hsa00230; hsa04022

18 known interactions (drugs) of input target (PDE5A): cGMP-specific 3',5'-cyclic phosphodiesterase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB00975 Dipyridamole Thumb
2 Experimental SmallMoleculeDrug DB08729 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide Thumb
3 Approved SmallMoleculeDrug DB06237 Avanafil Thumb
4 Experimental SmallMoleculeDrug DB07954 3-isobutyl-1-methyl-7H-xanthine Thumb
5 Approved SmallMoleculeDrug DB00201 Caffeine Thumb
6 Experimental SmallMoleculeDrug DB01972 Guanosine-5'-Monophosphate Thumb
7 Approved SmallMoleculeDrug DB00862 Vardenafil Thumb
8 Investigational SmallMoleculeDrug DB06246 Exisulind Thumb
9 Approved;
SmallMoleculeDrug DB00820 Tadalafil Thumb
10 Approved;
SmallMoleculeDrug DB00203 Sildenafil Thumb
11 Approved SmallMoleculeDrug DB00277 Theophylline Thumb
12 Investigational SmallMoleculeDrug DB05415 OSI-461 Thumb
13 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
14 Approved;
SmallMoleculeDrug DB00806 Pentoxifylline Thumb
15 Experimental SmallMoleculeDrug DB03597 Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine Thumb
16 Approved;
SmallMoleculeDrug DB06267 Udenafil Thumb
17 Approved SmallMoleculeDrug DB09283 Trapidil Thumb
18 Approved;
Vet approved
SmallMoleculeDrug DB04272 Citric Acid Thumb

20 predicted interactions (drugs) of input target (PDE5A): cGMP-specific 3',5'-cyclic phosphodiesterase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB08811 Tofisopam Thumb 45.6%
2 Approved SmallMoleculeDrug DB00651 Dyphylline Thumb 44.0%
3 Experimental SmallMoleculeDrug DB04522 Dexfosfoserine Thumb 37.3%
4 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 32.1%
5 Approved;
SmallMoleculeDrug DB00824 Enprofylline Thumb 31.6%
6 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb 30.8%
7 Approved;
SmallMoleculeDrug DB05219 Crisaborole Thumb 30.4%
8 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 29.6%
9 Experimental SmallMoleculeDrug DB08299 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Thumb 29.5%
10 Approved;
SmallMoleculeDrug DB00143 Glutathione Thumb 29.5%
11 Approved;
SmallMoleculeDrug DB05266 Ibudilast Thumb 29.3%
12 Investigational;
SmallMoleculeDrug DB00171 ATP Thumb 28.9%
13 Experimental SmallMoleculeDrug DB04530 S,S-(2-Hydroxyethyl)Thiocysteine Thumb 28.6%
14 Investigational SmallMoleculeDrug DB05241 XL765 Thumb 28.4%
15 Experimental SmallMoleculeDrug DB03814 2-(N-Morpholino)-Ethanesulfonic Acid Thumb 28.3%
16 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 27.5%
17 Approved;
SmallMoleculeDrug DB01412 Theobromine Thumb 27.0%
18 Approved SmallMoleculeDrug DB01656 Roflumilast Thumb 26.9%
19 Experimental SmallMoleculeDrug DB02315 Cyclic Guanosine Monophosphate Thumb 25.6%
20 Investigational SmallMoleculeDrug DB06479 Propentofylline Thumb 24.9%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.