QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P47775
No. Gene UniProt ID Protein Name Pathway PDB
1 GPR12 P47775 G-protein coupled receptor 12 NA NA


3 known interactions (drugs) of input target (GPR12): G-protein coupled receptor 12
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB14011 Nabiximols Thumb
2 Experimental;
Investigational		 BiotechDrug DB14009 Medical Cannabis Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB09061 Cannabidiol Thumb


20 predicted interactions (drugs) of input target (GPR12): G-protein coupled receptor 12
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb 46.9%
2 Approved SmallMoleculeDrug DB01744 Camphor Thumb 35.9%
3 Experimental SmallMoleculeDrug DB02955 Ricinoleic Acid Thumb 35.1%
4 Investigational SmallMoleculeDrug DB14050 Cannabidivarin Thumb 32.2%
5 Experimental SmallMoleculeDrug DB11345 (S)-camphor Thumb 31.5%
6 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb 25.8%
7 Approved SmallMoleculeDrug DB00825 Menthol Thumb 25.2%
8 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 25.1%
9 Investigational SmallMoleculeDrug DB05885 Seletracetam Thumb 24.6%
10 Approved;
Investigational		 SmallMoleculeDrug DB06155 Rimonabant Thumb 24.1%
11 Approved;
Illicit		 SmallMoleculeDrug DB00470 Dronabinol Thumb 23.7%
12 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb 23.7%
13 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb 22.5%
14 Approved;
Nutraceutical		 SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb 21.4%
15 Approved;
Investigational		 SmallMoleculeDrug DB09288 Propacetamol Thumb 21.3%
16 Approved SmallMoleculeDrug DB04841 Flunarizine Thumb 20.5%
17 Approved;
Investigational		 SmallMoleculeDrug DB00486 Nabilone Thumb 20.3%
18 Approved;
Withdrawn		 SmallMoleculeDrug DB11148 Butamben Thumb 19.9%
19 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 19.8%
20 Approved SmallMoleculeDrug DB09086 Eugenol Thumb 19.1%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.