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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P11229
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRM1 P11229 Muscarinic acetylcholine receptor M1 hsa04020; hsa04024; hsa04080; hsa04151; hsa04725; hsa04810 NA

103 known interactions (drugs) of input target (CHRM1): Muscarinic acetylcholine receptor M1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved SmallMoleculeDrug DB00782 Propantheline Thumb
2 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb
3 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
4 Approved SmallMoleculeDrug DB00785 Cryptenamine Thumb
5 Approved SmallMoleculeDrug DB00209 Trospium Thumb
6 Approved SmallMoleculeDrug DB00219 Oxyphenonium Thumb
7 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
8 Approved;
SmallMoleculeDrug DB01062 Oxybutynin Thumb
9 Approved;
SmallMoleculeDrug DB00193 Tramadol Thumb
10 Approved SmallMoleculeDrug DB00332 Ipratropium Thumb
11 Approved;
SmallMoleculeDrug DB12278 Propiverine Thumb
12 Approved;
Vet approved
SmallMoleculeDrug DB00366 Doxylamine Thumb
13 Experimental SmallMoleculeDrug DB04365 Arecoline Thumb
14 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
15 Approved SmallMoleculeDrug DB08897 Aclidinium Thumb
16 Approved;
SmallMoleculeDrug DB01142 Doxepin Thumb
17 Approved;
SmallMoleculeDrug DB00334 Olanzapine Thumb
18 Approved;
SmallMoleculeDrug DB01233 Metoclopramide Thumb
19 Approved SmallMoleculeDrug DB04843 Mepenzolate Thumb
20 Withdrawn SmallMoleculeDrug DB00767 Benzquinamide Thumb
21 Approved SmallMoleculeDrug DB00979 Cyclopentolate Thumb
22 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
23 Approved;
SmallMoleculeDrug DB00622 Nicardipine Thumb
24 Approved SmallMoleculeDrug DB00383 Oxyphencyclimine Thumb
25 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb
26 Approved;
SmallMoleculeDrug DB01175 Escitalopram Thumb
27 Approved;
SmallMoleculeDrug DB01239 Chlorprothixene Thumb
28 Approved;
SmallMoleculeDrug DB01231 Diphenidol Thumb
29 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
30 Approved SmallMoleculeDrug DB00835 Brompheniramine Thumb
31 Approved SmallMoleculeDrug DB00805 Minaprine Thumb
32 Approved SmallMoleculeDrug DB00202 Succinylcholine Thumb
33 Approved;
SmallMoleculeDrug DB00907 Cocaine Thumb
34 Approved SmallMoleculeDrug DB06702 Fesoterodine Thumb
35 Approved SmallMoleculeDrug DB00411 Carbachol Thumb
36 Approved SmallMoleculeDrug DB03128 Acetylcholine Thumb
37 Approved;
SmallMoleculeDrug DB01238 Aripiprazole Thumb
38 Approved SmallMoleculeDrug DB00462 Methylscopolamine bromide Thumb
39 Approved SmallMoleculeDrug DB01148 Flavoxate Thumb
40 Approved SmallMoleculeDrug DB00424 Hyoscyamine Thumb
41 Approved SmallMoleculeDrug DB00804 Dicyclomine Thumb
42 Approved;
SmallMoleculeDrug DB00555 Lamotrigine Thumb
43 Investigational SmallMoleculeDrug DB05752 ALKS 27 Thumb
44 Investigational SmallMoleculeDrug DB05152 NGX267 Thumb
45 Approved SmallMoleculeDrug DB01019 Bethanechol Thumb
46 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
47 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
48 Approved;
SmallMoleculeDrug DB01151 Desipramine Thumb
49 Approved;
SmallMoleculeDrug DB00568 Cinnarizine Thumb
50 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
51 Approved;
SmallMoleculeDrug DB01085 Pilocarpine Thumb
52 Approved SmallMoleculeDrug DB00185 Cevimeline Thumb
53 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
54 Approved;
Vet approved
SmallMoleculeDrug DB01221 Ketamine Thumb
55 Approved SmallMoleculeDrug DB00354 Buclizine Thumb
56 Approved SmallMoleculeDrug DB00245 Benzatropine Thumb
57 Approved SmallMoleculeDrug DB00725 Homatropine Methylbromide Thumb
58 Approved;
SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
59 Approved;
SmallMoleculeDrug DB00496 Darifenacin Thumb
60 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
61 Approved;
Vet approved
SmallMoleculeDrug DB00508 Triflupromazine Thumb
62 Approved SmallMoleculeDrug DB11235 Thonzylamine Thumb
63 Approved SmallMoleculeDrug DB06787 Hexocyclium Thumb
64 Approved SmallMoleculeDrug DB00215 Citalopram Thumb
65 Approved SmallMoleculeDrug DB01409 Tiotropium Thumb
66 Withdrawn SmallMoleculeDrug DB00505 Tridihexethyl Thumb
67 Approved;
SmallMoleculeDrug DB01069 Promethazine Thumb
68 Approved;
Vet approved
SmallMoleculeDrug DB00572 Atropine Thumb
69 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
70 Approved;
SmallMoleculeDrug DB09262 Imidafenacin Thumb
71 Approved SmallMoleculeDrug DB00340 Metixene Thumb
72 Approved;
Vet approved
SmallMoleculeDrug DB00477 Chlorpromazine Thumb
73 Approved SmallMoleculeDrug DB00771 Clidinium Thumb
74 Approved;
SmallMoleculeDrug DB01036 Tolterodine Thumb
75 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
76 Approved;
SmallMoleculeDrug DB00934 Maprotiline Thumb
77 Approved SmallMoleculeDrug DB01591 Solifenacin Thumb
78 Approved;
SmallMoleculeDrug DB00342 Terfenadine Thumb
79 Approved;
SmallMoleculeDrug DB00809 Tropicamide Thumb
80 Investigational SmallMoleculeDrug DB05766 ACP-104 Thumb
81 Approved;
SmallMoleculeDrug DB00940 Methantheline Thumb
82 Approved SmallMoleculeDrug DB00376 Trihexyphenidyl Thumb
83 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb
84 Approved SmallMoleculeDrug DB00387 Procyclidine Thumb
85 Approved SmallMoleculeDrug DB09076 Umeclidinium Thumb
86 Approved SmallMoleculeDrug DB00517 Anisotropine Methylbromide Thumb
87 Approved;
Vet approved
SmallMoleculeDrug DB11156 Pyrantel Thumb
88 Approved SmallMoleculeDrug DB00670 Pirenzepine Thumb
89 Approved SmallMoleculeDrug DB11181 Homatropine Thumb
90 Approved SmallMoleculeDrug DB00942 Cycrimine Thumb
91 Approved SmallMoleculeDrug DB01618 Molindone Thumb
92 Approved;
SmallMoleculeDrug DB00747 Scopolamine Thumb
93 Approved SmallMoleculeDrug DB00483 Gallamine Triethiodide Thumb
94 Approved;
SmallMoleculeDrug DB00875 Flupentixol Thumb
95 Approved SmallMoleculeDrug DB00392 Ethopropazine Thumb
96 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb
97 Approved;
Vet approved
SmallMoleculeDrug DB00420 Promazine Thumb
98 Approved;
SmallMoleculeDrug DB00810 Biperiden Thumb
99 Approved;
SmallMoleculeDrug DB00715 Paroxetine Thumb
100 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
101 Approved;
Vet approved
SmallMoleculeDrug DB00986 Glycopyrronium Thumb
102 Approved;
SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
103 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb

20 predicted interactions (drugs) of input target (CHRM1): Muscarinic acetylcholine receptor M1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB01075 Diphenhydramine Thumb 83.3%
2 Approved;
SmallMoleculeDrug DB08801 Dimetindene Thumb 82.7%
3 Approved;
Vet approved
SmallMoleculeDrug DB01625 Isopropamide Thumb 81.8%
4 Approved SmallMoleculeDrug DB01226 Mivacurium Thumb 79.7%
5 Investigational SmallMoleculeDrug DB04924 Itopride Thumb 79.0%
6 Approved;
Vet approved
SmallMoleculeDrug DB09300 Butylscopolamine Thumb 78.8%
7 Approved SmallMoleculeDrug DB01337 Pancuronium Thumb 78.8%
8 Approved SmallMoleculeDrug DB01338 Pipecuronium Thumb 78.2%
9 Withdrawn SmallMoleculeDrug DB04834 Rapacuronium Thumb 75.8%
10 Approved;
SmallMoleculeDrug DB06709 Methacholine Thumb 75.4%
11 Approved SmallMoleculeDrug DB00728 Rocuronium Thumb 74.9%
12 Approved;
Vet approved
SmallMoleculeDrug DB00599 Thiopental Thumb 74.0%
13 Approved SmallMoleculeDrug DB01336 Metocurine Thumb 72.6%
14 Approved SmallMoleculeDrug DB01135 Doxacurium chloride Thumb 72.1%
15 Approved;
Vet approved;
SmallMoleculeDrug DB00729 Diphemanil Methylsulfate Thumb 71.7%
16 Approved;
SmallMoleculeDrug DB06016 Cariprazine Thumb 70.6%
17 Approved SmallMoleculeDrug DB06216 Asenapine Thumb 69.4%
18 Approved;
SmallMoleculeDrug DB06148 Mianserin Thumb 67.0%
19 Approved SmallMoleculeDrug DB01622 Thioproperazine Thumb 66.1%
20 Approved;
SmallMoleculeDrug DB01200 Bromocriptine Thumb 65.6%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.