QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P22460
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNA5 P22460 Potassium voltage-gated channel subfamily A member 5 NA NA


3 known interactions (drugs) of input target (KCNA5): Potassium voltage-gated channel subfamily A member 5
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb
2 Approved SmallMoleculeDrug DB06637 Dalfampridine Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB06217 Vernakalant Thumb


20 predicted interactions (drugs) of input target (KCNA5): Potassium voltage-gated channel subfamily A member 5
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb 31.4%
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB00172 L-Proline Thumb 23.4%
3 Approved;
Withdrawn		 SmallMoleculeDrug DB01195 Flecainide Thumb 22.1%
4 Approved;
Investigational		 SmallMoleculeDrug DB01118 Amiodarone Thumb 22.1%
5 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb 21.6%
6 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 21.5%
7 Approved SmallMoleculeDrug DB00458 Imipramine Thumb 20.2%
8 Approved SmallMoleculeDrug DB01035 Procainamide Thumb 19.1%
9 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 17.3%
10 Approved;
Investigational		 SmallMoleculeDrug DB05541 Brivaracetam Thumb 17.2%
11 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb 15.6%
12 Approved;
Investigational		 SmallMoleculeDrug DB00270 Isradipine Thumb 15.5%
13 Approved;
Investigational		 SmallMoleculeDrug DB00455 Loratadine Thumb 15.1%
14 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01228 Encainide Thumb 14.8%
15 Approved;
Investigational		 SmallMoleculeDrug DB00908 Quinidine Thumb 14.7%
16 Approved;
Investigational		 SmallMoleculeDrug DB00583 L-Carnitine Thumb 14.5%
17 Approved SmallMoleculeDrug DB04855 Dronedarone Thumb 14.4%
18 Approved SmallMoleculeDrug DB02659 Cholic Acid Thumb 14.3%
19 Approved SmallMoleculeDrug DB04552 Niflumic Acid Thumb 14.3%
20 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00199 Erythromycin Thumb 14.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.