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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P04626
No. Gene UniProt ID Protein Name Pathway PDB
1 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 hsa01521; hsa01522; hsa01524; hsa04010; hsa04012; hsa04020; hsa04066; hsa04151; hsa04510; hsa04520; hsa04530; hsa05200; hsa05205; hsa05206; hsa05212; hsa05213; hsa05215; hsa05219; hsa05223; hsa05224; hsa05226; hsa05230

12 known interactions (drugs) of input target (ERBB2): Receptor tyrosine-protein kinase erbB-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
BiotechDrug DB00072 Trastuzumab Thumb
2 Approved;
BiotechDrug DB05773 Trastuzumab emtansine Thumb
3 Investigational SmallMoleculeDrug DB05944 Varlitinib Thumb
4 Approved;
SmallMoleculeDrug DB01259 Lapatinib Thumb
5 Investigational BiotechDrug DB04988 IGN311 Thumb
6 Investigational SmallMoleculeDrug DB06021 AV-412 Thumb
7 Approved SmallMoleculeDrug DB08916 Afatinib Thumb
8 Investigational SmallMoleculeDrug DB11652 Tucatinib Thumb
9 Approved BiotechDrug DB06366 Pertuzumab Thumb
10 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
11 Investigational SmallMoleculeDrug DB11973 Tesevatinib Thumb
12 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb

20 predicted interactions (drugs) of input target (ERBB2): Receptor tyrosine-protein kinase erbB-2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved BiotechDrug DB00002 Cetuximab Thumb 45.2%
2 Approved;
SmallMoleculeDrug DB01254 Dasatinib Thumb 38.2%
3 Approved;
BiotechDrug DB09559 Necitumumab Thumb 35.4%
4 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 35.4%
5 Approved;
Vet approved
SmallMoleculeDrug DB00281 Lidocaine Thumb 35.3%
6 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 35.0%
7 Investigational SmallMoleculeDrug DB05424 Canertinib Thumb 34.4%
8 Investigational SmallMoleculeDrug DB05374 Rindopepimut Thumb 33.2%
9 Approved;
Vet approved
SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 32.4%
10 Experimental SmallMoleculeDrug DB02379 Beta-D-Glucose Thumb 31.8%
11 Approved;
SmallMoleculeDrug DB13164 Olmutinib Thumb 31.5%
12 Approved;
SmallMoleculeDrug DB00317 Gefitinib Thumb 30.3%
13 Investigational BiotechDrug DB05101 Matuzumab Thumb 30.2%
14 Approved;
SmallMoleculeDrug DB11828 Neratinib Thumb 29.2%
15 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 28.2%
16 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 28.2%
17 Approved;
SmallMoleculeDrug DB11737 Icotinib Thumb 27.9%
18 Experimental SmallMoleculeDrug DB07602 S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE Thumb 27.7%
19 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb 26.6%
20 Investigational SmallMoleculeDrug DB05524 Pelitinib Thumb 26.1%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.