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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P54219
No. Gene UniProt ID Protein Name Pathway PDB
1 SLC18A1 P54219 Chromaffin granule amine transporter hsa04721; hsa04726; hsa04728; hsa05012; hsa05030; hsa05031; hsa05034 NA


5 known interactions (drugs) of input target (SLC18A1): Chromaffin granule amine transporter
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb
2 Approved;
Illicit		 SmallMoleculeDrug DB01577 Methamphetamine Thumb
3 Approved;
Nutraceutical;
Withdrawn		 SmallMoleculeDrug DB01363 Ephedra Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00206 Reserpine Thumb
5 Experimental;
Illicit		 SmallMoleculeDrug DB01442 MMDA Thumb


20 predicted interactions (drugs) of input target (SLC18A1): Chromaffin granule amine transporter
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb 62.2%
2 Experimental;
Illicit		 SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb 60.1%
3 Approved;
Illicit		 SmallMoleculeDrug DB00865 Benzphetamine Thumb 53.4%
4 Approved;
Illicit		 SmallMoleculeDrug DB01576 Dextroamphetamine Thumb 46.8%
5 Investigational;
Nutraceutical		 SmallMoleculeDrug DB08839 Serotonin Thumb 43.2%
6 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 42.8%
7 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb 42.8%
8 Approved;
Illicit		 SmallMoleculeDrug DB00191 Phentermine Thumb 42.4%
9 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 42.4%
10 Withdrawn SmallMoleculeDrug DB04821 Nomifensine Thumb 41.6%
11 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 41.1%
12 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 39.4%
13 Experimental;
Illicit;
Investigational		 SmallMoleculeDrug DB01454 Midomafetamine Thumb 39.2%
14 Approved;
Investigational		 SmallMoleculeDrug DB06262 Droxidopa Thumb 39.2%
15 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 39.1%
16 Approved;
Investigational		 SmallMoleculeDrug DB00579 Mazindol Thumb 39.0%
17 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb 38.3%
18 Withdrawn SmallMoleculeDrug DB04832 Zimelidine Thumb 38.2%
19 Approved;
Investigational		 SmallMoleculeDrug DB05381 Histamine Thumb 38.1%
20 Approved SmallMoleculeDrug DB09244 Pirlindole Thumb 37.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.