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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P48051
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNJ6 P48051 G protein-activated inward rectifier potassium channel 2 hsa04713; hsa04723; hsa04725; hsa04726; hsa04727; hsa04728; hsa04915; hsa04921; hsa05032 NA


3 known interactions (drugs) of input target (KCNJ6): G protein-activated inward rectifier potassium channel 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb
2 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb
3 Approved SmallMoleculeDrug DB00898 Ethanol Thumb


20 predicted interactions (drugs) of input target (KCNJ6): G protein-activated inward rectifier potassium channel 2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb 38.8%
2 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb 35.2%
3 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb 34.7%
4 Approved;
Investigational		 SmallMoleculeDrug DB00402 Eszopiclone Thumb 33.8%
5 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 31.7%
6 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 31.3%
7 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb 30.9%
8 Approved;
Vet approved		 SmallMoleculeDrug DB01154 Thiamylal Thumb 30.2%
9 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 30.1%
10 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 28.6%
11 Approved;
Illicit		 SmallMoleculeDrug DB01068 Clonazepam Thumb 28.5%
12 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb 28.5%
13 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 28.3%
14 Approved SmallMoleculeDrug DB01189 Desflurane Thumb 28.1%
15 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb 28.0%
16 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 28.0%
17 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb 27.6%
18 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 27.4%
19 Approved;
Illicit		 SmallMoleculeDrug DB00371 Meprobamate Thumb 27.2%
20 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb 27.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.