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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P27338
No. Gene UniProt ID Protein Name Pathway PDB
1 MAOB P27338 Amine oxidase [flavin-containing] B hsa00260; hsa00330; hsa00340; hsa00350; hsa00360; hsa00380; hsa00982; hsa01100; hsa04726; hsa04728; hsa05030; hsa05031; hsa05034

36 known interactions (drugs) of input target (MAOB): Amine oxidase [flavin-containing] B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB08176 (1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE Thumb
2 Withdrawn SmallMoleculeDrug DB04832 Zimelidine Thumb
3 Approved SmallMoleculeDrug DB01247 Isocarboxazid Thumb
4 Approved;
SmallMoleculeDrug DB01171 Moclobemide Thumb
5 Approved;
SmallMoleculeDrug DB00752 Tranylcypromine Thumb
6 Approved;
SmallMoleculeDrug DB00191 Phentermine Thumb
7 Approved;
SmallMoleculeDrug DB06654 Safinamide Thumb
8 Approved SmallMoleculeDrug DB01626 Pargyline Thumb
9 Experimental SmallMoleculeDrug DB08082 N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE Thumb
10 Experimental SmallMoleculeDrug DB04677 N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE Thumb
11 Approved;
Vet approved
SmallMoleculeDrug DB00721 Procaine Thumb
12 Experimental SmallMoleculeDrug DB07512 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE Thumb
13 Experimental SmallMoleculeDrug DB07513 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE Thumb
14 Approved;
SmallMoleculeDrug DB01577 Methamphetamine Thumb
15 Experimental SmallMoleculeDrug DB02211 N-Methyl-N-Propargyl-1(R)-Aminoindan Thumb
16 Experimental SmallMoleculeDrug DB03894 N-Propargyl-1(S)-Aminoindan Thumb
17 Experimental SmallMoleculeDrug DB02095 Isatin Thumb
18 Approved SmallMoleculeDrug DB00780 Phenelzine Thumb
19 Approved SmallMoleculeDrug DB03147 Flavin adenine dinucleotide Thumb
20 Experimental SmallMoleculeDrug DB04307 5-Hydroxy-N-Propargyl-1(R)-Aminoindan Thumb
21 Withdrawn SmallMoleculeDrug DB04821 Nomifensine Thumb
22 Experimental SmallMoleculeDrug DB04147 Lauryl Dimethylamine-N-Oxide Thumb
23 Approved SmallMoleculeDrug DB01367 Rasagiline Thumb
24 Experimental;
SmallMoleculeDrug DB01442 MMDA Thumb
25 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb
26 Experimental SmallMoleculeDrug DB08480 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN Thumb
27 Experimental;
SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb
28 Experimental SmallMoleculeDrug DB02643 N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate Thumb
29 Experimental SmallMoleculeDrug DB02509 Farnesol Thumb
30 Approved;
SmallMoleculeDrug DB00182 Amphetamine Thumb
31 Approved;
SmallMoleculeDrug DB01363 Ephedra Thumb
32 Approved;
SmallMoleculeDrug DB01132 Pioglitazone Thumb
33 Withdrawn SmallMoleculeDrug DB04820 Nialamide Thumb
34 Experimental SmallMoleculeDrug DB08516 (S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE] Thumb
35 Approved;
SmallMoleculeDrug DB01168 Procarbazine Thumb
36 Approved;
Vet approved
SmallMoleculeDrug DB01037 Selegiline Thumb

20 predicted interactions (drugs) of input target (MAOB): Amine oxidase [flavin-containing] B
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB09245 Toloxatone Thumb 48.7%
2 Experimental SmallMoleculeDrug DB07641 Decyl(dimethyl)phosphine oxide Thumb 46.8%
3 Experimental SmallMoleculeDrug DB13876 Brofaromine Thumb 46.8%
4 Investigational SmallMoleculeDrug DB04850 Posizolid Thumb 44.8%
5 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 44.6%
6 Experimental SmallMoleculeDrug DB07919 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE Thumb 43.4%
7 Approved;
SmallMoleculeDrug DB00579 Mazindol Thumb 42.1%
8 Experimental SmallMoleculeDrug DB04017 Clorgiline Thumb 42.0%
9 Approved;
SmallMoleculeDrug DB00206 Reserpine Thumb 41.3%
10 Approved;
SmallMoleculeDrug DB00313 Valproic Acid Thumb 41.3%
11 Investigational SmallMoleculeDrug DB05205 CX157 Thumb 40.7%
12 Approved SmallMoleculeDrug DB09244 Pirlindole Thumb 40.6%
13 Approved;
SmallMoleculeDrug DB00907 Cocaine Thumb 39.0%
14 Approved;
SmallMoleculeDrug DB06701 Dexmethylphenidate Thumb 38.7%
15 Approved SmallMoleculeDrug DB01104 Sertraline Thumb 36.7%
16 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb 35.8%
17 Approved;
SmallMoleculeDrug DB00745 Modafinil Thumb 35.8%
18 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 35.3%
19 Approved SmallMoleculeDrug DB01161 Chloroprocaine Thumb 35.1%
20 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 34.3%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.