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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P11926
No. Gene UniProt ID Protein Name Pathway PDB
1 ODC1 P11926 Ornithine decarboxylase hsa00330; hsa00480; hsa01100 1D7K; 2ON3; 2OO0; 4ZGY

9 known interactions (drugs) of input target (ODC1): Ornithine decarboxylase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB04083 N'-Pyridoxyl-Lysine-5'-Monophosphate Thumb
2 Experimental SmallMoleculeDrug DB04263 Geneticin Thumb
3 Approved;
SmallMoleculeDrug DB06243 Eflornithine Thumb
4 Approved;
SmallMoleculeDrug DB00127 Spermine Thumb
5 Experimental SmallMoleculeDrug DB02209 Pyridoxine phosphate Thumb
6 Approved;
SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb
7 Experimental;
SmallMoleculeDrug DB03856 L-Eflornithine Thumb
8 Experimental SmallMoleculeDrug DB01917 Putrescine Thumb
9 Experimental SmallMoleculeDrug DB02824 N-Pyridoxyl-Glycine-5-Monophosphate Thumb

20 predicted interactions (drugs) of input target (ODC1): Ornithine decarboxylase
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB00133 Serine Thumb 27.2%
2 Experimental SmallMoleculeDrug DB01864 5'-Guanosine-Diphosphate-Monothiophosphate Thumb 25.5%
3 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 25.2%
4 Approved SmallMoleculeDrug DB00244 Mesalazine Thumb 24.7%
5 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 24.4%
6 Approved;
BiotechDrug DB11300 Thrombin Thumb 23.8%
7 Approved;
SmallMoleculeDrug DB01118 Amiodarone Thumb 23.7%
8 Approved;
SmallMoleculeDrug DB01136 Carvedilol Thumb 23.3%
9 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb 23.2%
10 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 22.6%
11 Approved;
SmallMoleculeDrug DB00313 Valproic Acid Thumb 22.3%
12 Approved SmallMoleculeDrug DB01162 Terazosin Thumb 22.1%
13 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb 21.9%
14 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 21.8%
15 Experimental SmallMoleculeDrug DB03461 2'-Monophosphoadenosine 5'-Diphosphoribose Thumb 21.5%
16 Approved;
SmallMoleculeDrug DB06148 Mianserin Thumb 21.2%
17 Approved SmallMoleculeDrug DB04552 Niflumic Acid Thumb 21.0%
18 Investigational SmallMoleculeDrug DB05492 Epicept NP-1 Thumb 20.8%
19 Approved;
Vet approved
SmallMoleculeDrug DB01110 Miconazole Thumb 20.7%
20 Approved;
SmallMoleculeDrug DB09130 Copper Thumb 20.7%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.