QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q96RJ0
No. Gene UniProt ID Protein Name Pathway PDB
1 TAAR1 Q96RJ0 Trace amine-associated receptor 1 hsa04080 NA


4 known interactions (drugs) of input target (TAAR1): Trace amine-associated receptor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB06714 Propylhexedrine Thumb
2 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
3 Approved;
Illicit		 SmallMoleculeDrug DB01576 Dextroamphetamine Thumb
4 Approved;
Illicit		 SmallMoleculeDrug DB01577 Methamphetamine Thumb


20 predicted interactions (drugs) of input target (TAAR1): Trace amine-associated receptor 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Nutraceutical;
Withdrawn		 SmallMoleculeDrug DB01363 Ephedra Thumb 51.7%
2 Approved SmallMoleculeDrug DB00368 Norepinephrine Thumb 43.6%
3 Experimental;
Illicit		 SmallMoleculeDrug DB01442 MMDA Thumb 42.8%
4 Experimental;
Illicit		 SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb 42.6%
5 Approved;
Illicit		 SmallMoleculeDrug DB00865 Benzphetamine Thumb 40.3%
6 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb 39.1%
7 Experimental;
Illicit;
Investigational		 SmallMoleculeDrug DB01454 Midomafetamine Thumb 37.0%
8 Withdrawn SmallMoleculeDrug DB04821 Nomifensine Thumb 36.6%
9 Approved SmallMoleculeDrug DB00988 Dopamine Thumb 35.7%
10 Approved;
Investigational		 SmallMoleculeDrug DB00579 Mazindol Thumb 35.5%
11 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb 34.8%
12 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb 34.5%
13 Approved;
Investigational		 SmallMoleculeDrug DB00206 Reserpine Thumb 34.4%
14 Approved SmallMoleculeDrug DB06706 Isometheptene Thumb 33.6%
15 Approved SmallMoleculeDrug DB01364 Ephedrine Thumb 32.3%
16 Approved;
Investigational		 SmallMoleculeDrug DB05381 Histamine Thumb 31.9%
17 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb 31.8%
18 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 31.5%
19 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb 30.9%
20 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb 30.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.