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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P11309
No. Gene UniProt ID Protein Name Pathway PDB
1 PIM1 P11309 Serine/threonine-protein kinase pim-1 hsa04630; hsa04933; hsa05200; hsa05206; hsa05221

23 known interactions (drugs) of input target (PIM1): Serine/threonine-protein kinase pim-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB03777 Rbt205 Inhibitor Thumb
2 Experimental;
SmallMoleculeDrug DB03366 Imidazole Thumb
3 Experimental SmallMoleculeDrug DB04522 Dexfosfoserine Thumb
4 Experimental;
SmallMoleculeDrug DB04216 Quercetin Thumb
5 Experimental SmallMoleculeDrug DB08708 N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine Thumb
6 Experimental SmallMoleculeDrug DB07524 N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine Thumb
7 Experimental SmallMoleculeDrug DB04715 IMIDAZOPYRIDAZIN 1 Thumb
8 Experimental SmallMoleculeDrug DB08230 5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE Thumb
9 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb
10 Experimental SmallMoleculeDrug DB07151 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one Thumb
11 Experimental SmallMoleculeDrug DB08707 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine Thumb
12 Experimental SmallMoleculeDrug DB01754 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One Thumb
13 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
14 Experimental SmallMoleculeDrug DB07242 (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Thumb
15 Experimental SmallMoleculeDrug DB02656 LY-294002 Thumb
16 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb
17 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb
18 Experimental SmallMoleculeDrug DB08166 (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Thumb
19 Experimental SmallMoleculeDrug DB04530 S,S-(2-Hydroxyethyl)Thiocysteine Thumb
20 Experimental SmallMoleculeDrug DB08022 (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile Thumb
21 Experimental SmallMoleculeDrug DB08709 2,3-diphenyl-1H-indole-7-carboxylic acid Thumb
22 Experimental SmallMoleculeDrug DB08705 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE Thumb
23 Experimental SmallMoleculeDrug DB03650 (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One Thumb

20 predicted interactions (drugs) of input target (PIM1): Serine/threonine-protein kinase pim-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 35.2%
2 Approved SmallMoleculeDrug DB00277 Theophylline Thumb 34.6%
3 Approved;
Vet approved
SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 34.3%
4 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb 34.2%
5 Experimental SmallMoleculeDrug DB04769 5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONE Thumb 31.6%
6 Approved SmallMoleculeDrug DB06637 Dalfampridine Thumb 30.6%
7 Approved;
SmallMoleculeDrug DB08912 Dabrafenib Thumb 29.9%
8 Experimental SmallMoleculeDrug DB03597 Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine Thumb 25.8%
9 Approved;
SmallMoleculeDrug DB00637 Astemizole Thumb 25.4%
10 Approved;
SmallMoleculeDrug DB00126 Vitamin C Thumb 25.2%
11 Experimental SmallMoleculeDrug DB03467 Naringenin Thumb 24.6%
12 Approved SmallMoleculeDrug DB00606 Cyclothiazide Thumb 24.1%
13 Experimental SmallMoleculeDrug DB08059 Wortmannin Thumb 23.9%
14 Approved;
SmallMoleculeDrug DB01069 Promethazine Thumb 23.7%
15 Experimental SmallMoleculeDrug DB07132 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA Thumb 23.6%
16 Experimental SmallMoleculeDrug DB07444 6-(3-AMINOPROPYL)-4,9-DIMETHYLPYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE Thumb 23.6%
17 Investigational SmallMoleculeDrug DB05241 XL765 Thumb 23.6%
18 Approved SmallMoleculeDrug DB00331 Metformin Thumb 23.4%
19 Approved BiotechDrug DB13932 Voretigene Neparvovec Thumb 23.4%
20 Experimental SmallMoleculeDrug DB04716 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Thumb 23.2%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.