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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q13393
No. Gene UniProt ID Protein Name Pathway PDB
1 PLD1 Q13393 Phospholipase D1 hsa00564; hsa00565; hsa01100; hsa04014; hsa04024; hsa04071; hsa04072; hsa04144; hsa04666; hsa04724; hsa04912; hsa04928; hsa05200; hsa05212; hsa05231 NA

3 known interactions (drugs) of input target (PLD1): Phospholipase D1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Investigational SmallMoleculeDrug DB05301 LAX-101 Thumb
2 Approved;
SmallMoleculeDrug DB00122 Choline Thumb
3 Approved;
SmallMoleculeDrug DB14006 Choline salicylate Thumb

20 predicted interactions (drugs) of input target (PLD1): Phospholipase D1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 21.0%
2 Approved SmallMoleculeDrug DB00674 Galantamine Thumb 19.6%
3 Approved;
SmallMoleculeDrug DB00172 L-Proline Thumb 19.6%
4 Investigational SmallMoleculeDrug DB04892 Phenserine Thumb 17.6%
5 Approved;
Vet approved
SmallMoleculeDrug DB00893 Iron Dextran Thumb 16.3%
6 Approved;
SmallMoleculeDrug DB00139 Succinic acid Thumb 16.1%
7 Approved;
BiotechDrug DB11767 Sarilumab Thumb 15.9%
8 Investigational SmallMoleculeDrug DB05137 Lobeline Thumb 15.7%
9 Approved;
SmallMoleculeDrug DB12267 Brigatinib Thumb 15.4%
10 Approved BiotechDrug DB06366 Pertuzumab Thumb 15.3%
11 Approved;
SmallMoleculeDrug DB00989 Rivastigmine Thumb 15.1%
12 Approved;
SmallMoleculeDrug DB13985 Lutetium Lu 177 dotatate Thumb 15.0%
13 Approved SmallMoleculeDrug DB00944 Demecarium Thumb 14.6%
14 Approved;
Vet approved
SmallMoleculeDrug DB00733 Pralidoxime Thumb 14.5%
15 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 14.4%
16 Experimental SmallMoleculeDrug DB03814 2-(N-Morpholino)-Ethanesulfonic Acid Thumb 14.2%
17 Investigational SmallMoleculeDrug DB11726 Encenicline Thumb 14.2%
18 Investigational;
BiotechDrug DB00111 Daclizumab Thumb 14.0%
19 Approved SmallMoleculeDrug DB01010 Edrophonium Thumb 14.0%
20 Approved SmallMoleculeDrug DB01090 Pentolinium Thumb 13.8%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.