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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P21397
No. Gene UniProt ID Protein Name Pathway PDB
1 MAOA P21397 Amine oxidase [flavin-containing] A hsa00260; hsa00330; hsa00340; hsa00350; hsa00360; hsa00380; hsa00982; hsa01100; hsa04726; hsa04728; hsa05030; hsa05031; hsa05034 1H8Q; 2BXR; 2BXS; 2Z5X; 2Z5Y

28 known interactions (drugs) of input target (MAOA): Amine oxidase [flavin-containing] A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Withdrawn SmallMoleculeDrug DB04832 Zimelidine Thumb
2 Approved SmallMoleculeDrug DB01247 Isocarboxazid Thumb
3 Approved;
SmallMoleculeDrug DB01171 Moclobemide Thumb
4 Approved;
SmallMoleculeDrug DB00752 Tranylcypromine Thumb
5 Approved;
SmallMoleculeDrug DB00191 Phentermine Thumb
6 Approved SmallMoleculeDrug DB01626 Pargyline Thumb
7 Investigational SmallMoleculeDrug DB04850 Posizolid Thumb
8 Approved SmallMoleculeDrug DB09244 Pirlindole Thumb
9 Approved;
Vet approved
SmallMoleculeDrug DB00721 Procaine Thumb
10 Experimental SmallMoleculeDrug DB13876 Brofaromine Thumb
11 Approved;
SmallMoleculeDrug DB01577 Methamphetamine Thumb
12 Approved SmallMoleculeDrug DB00805 Minaprine Thumb
13 Approved SmallMoleculeDrug DB00780 Phenelzine Thumb
14 Experimental SmallMoleculeDrug DB07641 Decyl(dimethyl)phosphine oxide Thumb
15 Approved SmallMoleculeDrug DB03147 Flavin adenine dinucleotide Thumb
16 Investigational SmallMoleculeDrug DB05205 CX157 Thumb
17 Withdrawn SmallMoleculeDrug DB04821 Nomifensine Thumb
18 Experimental SmallMoleculeDrug DB04017 Clorgiline Thumb
19 Experimental;
SmallMoleculeDrug DB01442 MMDA Thumb
20 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb
21 Experimental;
SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb
22 Approved;
SmallMoleculeDrug DB00182 Amphetamine Thumb
23 Approved;
SmallMoleculeDrug DB01363 Ephedra Thumb
24 Withdrawn SmallMoleculeDrug DB04820 Nialamide Thumb
25 Approved SmallMoleculeDrug DB09245 Toloxatone Thumb
26 Approved;
SmallMoleculeDrug DB01168 Procarbazine Thumb
27 Experimental SmallMoleculeDrug DB07919 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE Thumb
28 Approved;
Vet approved
SmallMoleculeDrug DB01037 Selegiline Thumb

20 predicted interactions (drugs) of input target (MAOA): Amine oxidase [flavin-containing] A
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb 50.3%
2 Approved;
SmallMoleculeDrug DB06654 Safinamide Thumb 49.7%
3 Experimental SmallMoleculeDrug DB07513 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE Thumb 48.9%
4 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 47.8%
5 Experimental SmallMoleculeDrug DB08082 N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE Thumb 47.5%
6 Approved;
SmallMoleculeDrug DB00907 Cocaine Thumb 47.3%
7 Experimental SmallMoleculeDrug DB08516 (S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE] Thumb 47.0%
8 Experimental SmallMoleculeDrug DB02509 Farnesol Thumb 46.9%
9 Approved SmallMoleculeDrug DB01367 Rasagiline Thumb 46.5%
10 Experimental SmallMoleculeDrug DB04677 N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE Thumb 44.6%
11 Experimental SmallMoleculeDrug DB07512 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE Thumb 44.0%
12 Experimental SmallMoleculeDrug DB08480 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN Thumb 43.5%
13 Experimental SmallMoleculeDrug DB04307 5-Hydroxy-N-Propargyl-1(R)-Aminoindan Thumb 42.4%
14 Experimental;
SmallMoleculeDrug DB01454 Midomafetamine Thumb 42.4%
15 Approved;
SmallMoleculeDrug DB06701 Dexmethylphenidate Thumb 42.2%
16 Experimental SmallMoleculeDrug DB02095 Isatin Thumb 42.1%
17 Experimental SmallMoleculeDrug DB02211 N-Methyl-N-Propargyl-1(R)-Aminoindan Thumb 42.1%
18 Experimental SmallMoleculeDrug DB08176 (1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE Thumb 42.1%
19 Approved SmallMoleculeDrug DB01161 Chloroprocaine Thumb 41.7%
20 Experimental SmallMoleculeDrug DB03894 N-Propargyl-1(S)-Aminoindan Thumb 41.5%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.