QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q7Z406
No. Gene UniProt ID Protein Name Pathway PDB
1 MYH14 Q7Z406 Myosin-14 hsa04530; hsa04810; hsa05132 2YCU


7 known interactions (drugs) of input target (MYH14): Myosin-14
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental SmallMoleculeDrug DB07470 (3aS)-3a-hydroxy-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one Thumb
2 Experimental SmallMoleculeDrug DB07469 (3aS)-3a-hydroxy-7-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one Thumb
3 Experimental SmallMoleculeDrug DB01944 (S)-blebbistatin Thumb
4 Experimental SmallMoleculeDrug DB04444 Tetrafluoroaluminate Ion Thumb
5 Experimental SmallMoleculeDrug DB03126 Mant-Adp Thumb
6 Experimental SmallMoleculeDrug DB08276 trifluoro-[hydroxy-[hydroxy-[2-(N-methyl-2-nitro-anilino)ethoxy]phosphoryl]oxy-phosphoryl]oxy-beryllium(1-) Thumb
7 Experimental SmallMoleculeDrug DB07468 (3aS)-3a-hydroxy-5-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one Thumb


20 predicted interactions (drugs) of input target (MYH14): Myosin-14
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB08348 N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Thumb 25.4%
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB00122 Choline Thumb 25.2%
3 Approved;
Withdrawn		 SmallMoleculeDrug DB09092 Xanthinol Thumb 21.7%
4 Nutraceutical SmallMoleculeDrug DB13191 Phosphocreatine Thumb 20.8%
5 Experimental SmallMoleculeDrug DB07375 5-BETA-ANDROSTANE-3,17-DIONE Thumb 20.6%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb 20.3%
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00141 N-Acetylglucosamine Thumb 19.7%
8 Approved;
Nutraceutical		 SmallMoleculeDrug DB14006 Choline salicylate Thumb 18.7%
9 Approved SmallMoleculeDrug DB11136 Chromium Thumb 18.4%
10 Approved;
Investigational		 SmallMoleculeDrug DB01103 Quinacrine Thumb 18.2%
11 Nutraceutical SmallMoleculeDrug DB00116 Tetrahydrofolic acid Thumb 17.9%
12 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb 17.8%
13 Experimental SmallMoleculeDrug DB02494 Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Thumb 17.0%
14 Experimental SmallMoleculeDrug DB02515 3-Phosphoglycerol Thumb 16.8%
15 Approved;
Nutraceutical		 SmallMoleculeDrug DB06757 Manganese Thumb 16.7%
16 Experimental SmallMoleculeDrug DB02309 5--Monophosphate-9-Beta-D-Ribofuranosyl Xanthine Thumb 16.6%
17 Experimental SmallMoleculeDrug DB07207 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE Thumb 16.1%
18 Approved SmallMoleculeDrug DB01162 Terazosin Thumb 16.0%
19 Experimental SmallMoleculeDrug DB04166 Anthranilic acid Thumb 15.6%
20 Approved;
Nutraceutical		 SmallMoleculeDrug DB00172 L-Proline Thumb 15.6%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.