QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: O14939
No. Gene UniProt ID Protein Name Pathway PDB
1 PLD2 O14939 Phospholipase D2 hsa00564; hsa00565; hsa01100; hsa04014; hsa04024; hsa04071; hsa04072; hsa04144; hsa04666; hsa04724; hsa04912; hsa04928; hsa05231 NA


2 known interactions (drugs) of input target (PLD2): Phospholipase D2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00122 Choline Thumb
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB14006 Choline salicylate Thumb


20 predicted interactions (drugs) of input target (PLD2): Phospholipase D2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb 26.4%
2 Experimental SmallMoleculeDrug DB03814 2-(N-Morpholino)-Ethanesulfonic Acid Thumb 24.5%
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB00157 NADH Thumb 19.9%
4 Investigational SmallMoleculeDrug DB05301 LAX-101 Thumb 19.7%
5 Approved SmallMoleculeDrug DB00674 Galantamine Thumb 19.7%
6 Approved;
Investigational		 SmallMoleculeDrug DB12267 Brigatinib Thumb 16.6%
7 Approved;
Vet approved		 SmallMoleculeDrug DB00733 Pralidoxime Thumb 16.4%
8 Investigational SmallMoleculeDrug DB04892 Phenserine Thumb 16.4%
9 Approved;
Investigational		 SmallMoleculeDrug DB01273 Varenicline Thumb 16.0%
10 Approved;
Investigational		 SmallMoleculeDrug DB09028 Cytisine Thumb 15.9%
11 Approved;
Investigational		 SmallMoleculeDrug DB00657 Mecamylamine Thumb 15.7%
12 Approved SmallMoleculeDrug DB01199 Tubocurarine Thumb 15.0%
13 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00677 Isoflurophate Thumb 14.6%
14 Approved SmallMoleculeDrug DB03128 Acetylcholine Thumb 14.5%
15 Approved;
Investigational		 SmallMoleculeDrug DB01088 Iloprost Thumb 14.5%
16 Approved;
Investigational		 SmallMoleculeDrug DB00824 Enprofylline Thumb 14.0%
17 Experimental SmallMoleculeDrug DB04250 Butyrylthiocholine Thumb 13.7%
18 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 13.6%
19 Approved;
Investigational		 SmallMoleculeDrug DB00545 Pyridostigmine Thumb 13.4%
20 Approved;
Illicit		 SmallMoleculeDrug DB01351 Amobarbital Thumb 13.3%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.