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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P14555
No. Gene UniProt ID Protein Name Pathway PDB
1 PLA2G2A P14555 Phospholipase A2, membrane associated hsa00564; hsa00565; hsa00590; hsa00591; hsa00592; hsa01100; hsa04014; hsa04270; hsa04972; hsa04975 1AYP; 1BBC; 1DB4; 1DB5; 1DCY; 1J1A; 1KQU; 1KVO; 1N28; 1N29; 1POD; 1POE; 2GNY; 3U8B; 3U8D; 3U8H; 3U8I


17 known interactions (drugs) of input target (PLA2G2A): Phospholipase A2, membrane associated
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Experimental SmallMoleculeDrug DB02448 N-Tridecanoic Acid Thumb
2 Experimental SmallMoleculeDrug DB01955 1,4-Butanediol Thumb
3 Experimental SmallMoleculeDrug DB03121 (1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid Thumb
4 Investigational SmallMoleculeDrug DB05737 Varespladib methyl Thumb
5 Approved;
Investigational
SmallMoleculeDrug DB04786 Suramin Thumb
6 Approved;
Experimental
SmallMoleculeDrug DB03017 Lauric Acid Thumb
7 Approved;
Investigational
SmallMoleculeDrug DB02325 Isopropyl Alcohol Thumb
8 Experimental SmallMoleculeDrug DB04287 (S)-5-(4-Benzyloxy-Phenyl)-4-(7-Phenyl-Heptanoylamino)-Pentanoic Acid Thumb
9 Experimental SmallMoleculeDrug DB02504 [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid Thumb
10 Experimental SmallMoleculeDrug DB02080 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene Thumb
11 Experimental SmallMoleculeDrug DB04112 1-Octadecyl-2-Acetamido-2-Deoxy-Sn-Glycerol-3-Phosphoethylmethyl Sulfide Thumb
12 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01381 Ginkgo biloba Thumb
13 Approved;
Vet approved
SmallMoleculeDrug DB00586 Diclofenac Thumb
14 Experimental SmallMoleculeDrug DB02936 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid Thumb
15 Experimental SmallMoleculeDrug DB03471 6-Phenyl-4(R)-(7-Phenyl-Heptanoylamino)-Hexanoic Acid Thumb
16 Approved;
Investigational
SmallMoleculeDrug DB00328 Indomethacin Thumb
17 Experimental SmallMoleculeDrug DB03784 Elaidoylamide Thumb


20 predicted interactions (drugs) of input target (PLA2G2A): Phospholipase A2, membrane associated
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Investigational SmallMoleculeDrug DB04725 Licofelone Thumb 35.9%
2 Withdrawn SmallMoleculeDrug DB04821 Nomifensine Thumb 34.1%
3 Approved;
Vet approved
SmallMoleculeDrug DB00939 Meclofenamic acid Thumb 31.1%
4 Approved;
Investigational
SmallMoleculeDrug DB00909 Zonisamide Thumb 28.5%
5 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB04743 Nimesulide Thumb 28.0%
6 Approved SmallMoleculeDrug DB00244 Mesalazine Thumb 27.8%
7 Approved SmallMoleculeDrug DB00795 Sulfasalazine Thumb 27.7%
8 Approved SmallMoleculeDrug DB06218 Lacosamide Thumb 27.0%
9 Approved;
Withdrawn
SmallMoleculeDrug DB00761 Potassium Chloride Thumb 26.9%
10 Approved SmallMoleculeDrug DB00594 Amiloride Thumb 26.6%
11 Experimental SmallMoleculeDrug DB04724 (S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE Thumb 26.5%
12 Approved SmallMoleculeDrug DB00233 Aminosalicylic Acid Thumb 26.4%
13 Approved SmallMoleculeDrug DB00292 Etomidate Thumb 25.6%
14 Approved;
Nutraceutical
SmallMoleculeDrug DB13961 Fish oil Thumb 24.9%
15 Experimental SmallMoleculeDrug DB04338 SB220025 Thumb 24.9%
16 Approved SmallMoleculeDrug DB08907 Canagliflozin Thumb 24.0%
17 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 23.4%
18 Approved SmallMoleculeDrug DB08439 Parecoxib Thumb 23.0%
19 Approved;
Investigational
SmallMoleculeDrug DB00412 Rosiglitazone Thumb 22.7%
20 Experimental SmallMoleculeDrug DB03297 Benzylsulfinic Acid Thumb 22.5%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.