QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q15825
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRNA6 Q15825 Neuronal acetylcholine receptor subunit alpha-6 hsa04080; hsa04725; hsa05033 NA


5 known interactions (drugs) of input target (CHRNA6): Neuronal acetylcholine receptor subunit alpha-6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00674 Galantamine Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB09028 Cytisine Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB01273 Varenicline Thumb
4 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
5 Approved SmallMoleculeDrug DB00184 Nicotine Thumb


20 predicted interactions (drugs) of input target (CHRNA6): Neuronal acetylcholine receptor subunit alpha-6
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb 56.2%
2 Investigational SmallMoleculeDrug DB05740 RPI-78M Thumb 50.3%
3 Experimental SmallMoleculeDrug DB07720 Epibatidine Thumb 47.2%
4 Approved;
Investigational		 SmallMoleculeDrug DB00657 Mecamylamine Thumb 40.8%
5 Approved;
Vet approved		 SmallMoleculeDrug DB00472 Fluoxetine Thumb 40.7%
6 Approved SmallMoleculeDrug DB00915 Amantadine Thumb 40.3%
7 Approved SmallMoleculeDrug DB01090 Pentolinium Thumb 39.7%
8 Approved;
Investigational		 SmallMoleculeDrug DB01227 Levomethadyl Acetate Thumb 39.5%
9 Approved;
Investigational		 SmallMoleculeDrug DB00981 Physostigmine Thumb 38.4%
10 Approved SmallMoleculeDrug DB01245 Decamethonium Thumb 36.8%
11 Investigational SmallMoleculeDrug DB05458 Pozanicline Thumb 36.1%
12 Approved;
Investigational		 SmallMoleculeDrug DB00564 Carbamazepine Thumb 35.5%
13 Investigational SmallMoleculeDrug DB05855 Rivanicline Thumb 34.1%
14 Investigational SmallMoleculeDrug DB05137 Lobeline Thumb 33.8%
15 Approved;
Investigational		 SmallMoleculeDrug DB00747 Scopolamine Thumb 33.1%
16 Approved;
Investigational;
Vet approved;
Withdrawn		 SmallMoleculeDrug DB00848 Levamisole Thumb 31.8%
17 Approved;
Vet approved		 SmallMoleculeDrug DB00572 Atropine Thumb 31.3%
18 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 31.1%
19 Approved;
Investigational		 SmallMoleculeDrug DB05541 Brivaracetam Thumb 29.6%
20 Approved SmallMoleculeDrug DB01199 Tubocurarine Thumb 28.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.