QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.


4 known interactions (drugs) of input target (CHUK): Inhibitor of nuclear factor kappa-B kinase subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00244 Mesalazine Thumb
2 Approved SmallMoleculeDrug DB00795 Sulfasalazine Thumb
3 Approved SmallMoleculeDrug DB00233 Aminosalicylic Acid Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB06151 Acetylcysteine Thumb


20 predicted interactions (drugs) of input target (CHUK): Inhibitor of nuclear factor kappa-B kinase subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Vet approved		 SmallMoleculeDrug DB00586 Diclofenac Thumb 33.4%
2 Approved;
Vet approved		 SmallMoleculeDrug DB00939 Meclofenamic acid Thumb 32.4%
3 Investigational SmallMoleculeDrug DB04725 Licofelone Thumb 29.0%
4 Approved;
Investigational		 SmallMoleculeDrug DB01014 Balsalazide Thumb 28.2%
5 Approved SmallMoleculeDrug DB09285 Morniflumate Thumb 28.1%
6 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 27.7%
7 Approved;
Investigational		 SmallMoleculeDrug DB09213 Dexibuprofen Thumb 27.6%
8 Approved;
Investigational		 SmallMoleculeDrug DB00995 Auranofin Thumb 27.0%
9 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 26.1%
10 Investigational SmallMoleculeDrug DB06521 Ertiprotafib Thumb 26.0%
11 Investigational SmallMoleculeDrug DB05183 MLN0415 Thumb 25.3%
12 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb 24.1%
13 Approved;
Investigational		 SmallMoleculeDrug DB11994 Diacerein Thumb 23.2%
14 Approved SmallMoleculeDrug DB01050 Ibuprofen Thumb 22.2%
15 Nutraceutical SmallMoleculeDrug DB01892 Hyperforin Thumb 22.1%
16 Experimental SmallMoleculeDrug DB03866 Prostaglandin G2 Thumb 21.9%
17 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 21.8%
18 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 21.7%
19 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00711 Diethylcarbamazine Thumb 21.4%
20 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 21.4%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.