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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P41743
No. Gene UniProt ID Protein Name Pathway PDB
1 PRKCI P41743 Protein kinase C iota type hsa04015; hsa04144; hsa04390; hsa04530; hsa04611; hsa04910; hsa05165 1VD2; 1WMH; 1ZRZ; 3A8W; 3A8X; 3ZH8

3 known interactions (drugs) of input target (PRKCI): Protein kinase C iota type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb
2 Experimental SmallMoleculeDrug DB03777 Rbt205 Inhibitor Thumb
3 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb

20 predicted interactions (drugs) of input target (PRKCI): Protein kinase C iota type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Experimental SmallMoleculeDrug DB02010 Staurosporine Thumb 35.7%
2 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 20.3%
3 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb 18.8%
4 Approved SmallMoleculeDrug DB05013 Ingenol Mebutate Thumb 17.4%
5 Experimental SmallMoleculeDrug DB04716 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Thumb 16.6%
6 Experimental;
SmallMoleculeDrug DB04216 Quercetin Thumb 16.6%
7 Approved;
SmallMoleculeDrug DB00367 Levonorgestrel Thumb 15.8%
8 Approved;
SmallMoleculeDrug DB08912 Dabrafenib Thumb 15.5%
9 Experimental SmallMoleculeDrug DB07242 (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile Thumb 15.4%
10 Experimental SmallMoleculeDrug DB07456 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione Thumb 15.1%
11 Approved;
SmallMoleculeDrug DB01149 Nefazodone Thumb 15.0%
12 Experimental SmallMoleculeDrug DB04395 Phosphoaminophosphonic Acid-Adenylate Ester Thumb 14.9%
13 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 14.7%
14 Experimental;
SmallMoleculeDrug DB08838 Agmatine Thumb 14.6%
15 Approved;
SmallMoleculeDrug DB03796 Palmitic Acid Thumb 14.5%
16 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 14.4%
17 Approved SmallMoleculeDrug DB00606 Cyclothiazide Thumb 14.2%
18 Experimental;
SmallMoleculeDrug DB01933 7-Hydroxystaurosporine Thumb 14.1%
19 Experimental SmallMoleculeDrug DB03721 N-acetyl-alpha-neuraminic acid Thumb 14.1%
20 Approved;
SmallMoleculeDrug DB08901 Ponatinib Thumb 14.0%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.