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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P08173
No. Gene UniProt ID Protein Name Pathway PDB
1 CHRM4 P08173 Muscarinic acetylcholine receptor M4 hsa04080; hsa04725; hsa04810 NA


58 known interactions (drugs) of input target (CHRM4): Muscarinic acetylcholine receptor M4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
2 Withdrawn SmallMoleculeDrug DB00767 Benzquinamide Thumb
3 Approved SmallMoleculeDrug DB01591 Solifenacin Thumb
4 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
5 Approved SmallMoleculeDrug DB00725 Homatropine Methylbromide Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB00622 Nicardipine Thumb
7 Approved;
Withdrawn		 SmallMoleculeDrug DB00342 Terfenadine Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB00809 Tropicamide Thumb
9 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01239 Chlorprothixene Thumb
10 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb
11 Approved SmallMoleculeDrug DB00785 Cryptenamine Thumb
12 Approved SmallMoleculeDrug DB00376 Trihexyphenidyl Thumb
13 Investigational SmallMoleculeDrug DB05752 ALKS 27 Thumb
14 Approved SmallMoleculeDrug DB03128 Acetylcholine Thumb
15 Approved SmallMoleculeDrug DB00387 Procyclidine Thumb
16 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
17 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
18 Approved SmallMoleculeDrug DB00363 Clozapine Thumb
19 Approved SmallMoleculeDrug DB09076 Umeclidinium Thumb
20 Approved SmallMoleculeDrug DB11235 Thonzylamine Thumb
21 Approved SmallMoleculeDrug DB06787 Hexocyclium Thumb
22 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb
23 Approved;
Vet approved		 SmallMoleculeDrug DB01625 Isopropamide Thumb
24 Approved SmallMoleculeDrug DB01409 Tiotropium Thumb
25 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb
26 Approved SmallMoleculeDrug DB06702 Fesoterodine Thumb
27 Approved SmallMoleculeDrug DB01019 Bethanechol Thumb
28 Approved SmallMoleculeDrug DB00411 Carbachol Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB00496 Darifenacin Thumb
30 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb
31 Approved SmallMoleculeDrug DB11181 Homatropine Thumb
32 Approved;
Investigational		 SmallMoleculeDrug DB00747 Scopolamine Thumb
33 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB12278 Propiverine Thumb
35 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB01069 Promethazine Thumb
37 Approved;
Investigational		 SmallMoleculeDrug DB00568 Cinnarizine Thumb
38 Approved;
Vet approved		 SmallMoleculeDrug DB00572 Atropine Thumb
39 Approved SmallMoleculeDrug DB00424 Hyoscyamine Thumb
40 Approved SmallMoleculeDrug DB00835 Brompheniramine Thumb
41 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb
42 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
43 Approved;
Vet approved		 SmallMoleculeDrug DB00420 Promazine Thumb
44 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
45 Approved SmallMoleculeDrug DB00340 Metixene Thumb
46 Approved;
Investigational		 SmallMoleculeDrug DB00715 Paroxetine Thumb
47 Approved SmallMoleculeDrug DB08897 Aclidinium Thumb
48 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
49 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
50 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb
51 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb
52 Approved;
Investigational		 SmallMoleculeDrug DB01036 Tolterodine Thumb
53 Approved;
Investigational		 SmallMoleculeDrug DB01403 Methotrimeprazine Thumb
54 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
55 Approved SmallMoleculeDrug DB00777 Propiomazine Thumb
56 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
57 Withdrawn SmallMoleculeDrug DB09194 Etoperidone Thumb
58 Approved;
Investigational		 SmallMoleculeDrug DB01085 Pilocarpine Thumb


20 predicted interactions (drugs) of input target (CHRM4): Muscarinic acetylcholine receptor M4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00483 Gallamine Triethiodide Thumb 87.8%
2 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb 87.1%
3 Approved SmallMoleculeDrug DB06153 Pizotifen Thumb 86.7%
4 Approved;
Vet approved		 SmallMoleculeDrug DB00508 Triflupromazine Thumb 83.2%
5 Approved;
Investigational		 SmallMoleculeDrug DB09262 Imidafenacin Thumb 82.9%
6 Approved SmallMoleculeDrug DB00383 Oxyphencyclimine Thumb 82.9%
7 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb 82.8%
8 Approved;
Investigational		 SmallMoleculeDrug DB01175 Escitalopram Thumb 81.4%
9 Approved;
Investigational		 SmallMoleculeDrug DB01062 Oxybutynin Thumb 79.5%
10 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb 79.4%
11 Approved SmallMoleculeDrug DB00202 Succinylcholine Thumb 79.3%
12 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb 79.3%
13 Approved SmallMoleculeDrug DB00805 Minaprine Thumb 79.0%
14 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00986 Glycopyrronium Thumb 78.7%
15 Approved SmallMoleculeDrug DB00185 Cevimeline Thumb 78.7%
16 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB09300 Butylscopolamine Thumb 78.4%
17 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01231 Diphenidol Thumb 78.4%
18 Withdrawn SmallMoleculeDrug DB00505 Tridihexethyl Thumb 78.2%
19 Approved SmallMoleculeDrug DB00280 Disopyramide Thumb 78.2%
20 Approved SmallMoleculeDrug DB00392 Ethopropazine Thumb 78.2%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.