QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P04054
No. Gene UniProt ID Protein Name Pathway PDB
1 PLA2G1B P04054 Phospholipase A2 hsa00564; hsa00565; hsa00590; hsa00591; hsa00592; hsa01100; hsa04014; hsa04270; hsa04972; hsa04975 1YSK; 3ELO


12 known interactions (drugs) of input target (PLA2G1B): Phospholipase A2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Experimental;
Investigational		 SmallMoleculeDrug DB02938 Heptanoic Acid Thumb
2 Experimental SmallMoleculeDrug DB02448 N-Tridecanoic Acid Thumb
3 Approved SmallMoleculeDrug DB00795 Sulfasalazine Thumb
4 Experimental SmallMoleculeDrug DB03565 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine Thumb
5 Approved SmallMoleculeDrug DB04552 Niflumic Acid Thumb
6 Experimental SmallMoleculeDrug DB03587 Pyruvaldehyde Thumb
7 Experimental SmallMoleculeDrug DB02210 Hexane-1,6-Diol Thumb
8 Approved SmallMoleculeDrug DB02659 Cholic Acid Thumb
9 Experimental SmallMoleculeDrug DB07836 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL Thumb
10 Experimental SmallMoleculeDrug DB02795 P-Anisic Acid Thumb
11 Experimental SmallMoleculeDrug DB03633 Lpc-Ether Thumb
12 Experimental SmallMoleculeDrug DB07657 PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER Thumb


20 predicted interactions (drugs) of input target (PLA2G1B): Phospholipase A2
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb 31.5%
2 Approved SmallMoleculeDrug DB01050 Ibuprofen Thumb 29.9%
3 Approved;
Investigational		 SmallMoleculeDrug DB09213 Dexibuprofen Thumb 28.0%
4 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 24.9%
5 Approved;
Nutraceutical		 SmallMoleculeDrug DB00159 Icosapent Thumb 24.8%
6 Approved;
Vet approved		 SmallMoleculeDrug DB00281 Lidocaine Thumb 24.3%
7 Approved SmallMoleculeDrug DB09295 Talniflumate Thumb 22.9%
8 Experimental SmallMoleculeDrug DB02266 Flufenamic Acid Thumb 22.9%
9 Approved;
Investigational		 SmallMoleculeDrug DB01118 Amiodarone Thumb 22.7%
10 Approved SmallMoleculeDrug DB00244 Mesalazine Thumb 22.5%
11 Approved;
Investigational		 SmallMoleculeDrug DB00412 Rosiglitazone Thumb 21.9%
12 Approved SmallMoleculeDrug DB00210 Adapalene Thumb 21.9%
13 Approved;
Vet approved		 SmallMoleculeDrug DB00741 Hydrocortisone Thumb 21.9%
14 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 21.6%
15 Approved SmallMoleculeDrug DB13165 Ripasudil Thumb 21.5%
16 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb 21.3%
17 Approved;
Nutraceutical		 SmallMoleculeDrug DB13961 Fish oil Thumb 21.2%
18 Approved SmallMoleculeDrug DB06201 Rufinamide Thumb 21.1%
19 Investigational SmallMoleculeDrug DB05041 RP101 Thumb 20.9%
20 Approved;
Investigational		 SmallMoleculeDrug DB00482 Celecoxib Thumb 20.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.