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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P31644
No. Gene UniProt ID Protein Name Pathway PDB
1 GABRA5 P31644 Gamma-aminobutyric acid receptor subunit alpha-5 hsa04080; hsa04723; hsa04727; hsa04742; hsa05032; hsa05033 NA


69 known interactions (drugs) of input target (GABRA5): Gamma-aminobutyric acid receptor subunit alpha-5
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb
3 Approved;
Illicit		 SmallMoleculeDrug DB01352 Aprobarbital Thumb
4 Approved;
Illicit		 SmallMoleculeDrug DB01589 Quazepam Thumb
5 Approved;
Illicit		 SmallMoleculeDrug DB01588 Prazepam Thumb
6 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00404 Alprazolam Thumb
7 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb
8 Investigational SmallMoleculeDrug DB06579 Adipiplon Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB11901 Apalutamide Thumb
10 Approved;
Illicit		 SmallMoleculeDrug DB01567 Fludiazepam Thumb
11 Approved SmallMoleculeDrug DB01355 Hexobarbital Thumb
12 Approved SmallMoleculeDrug DB01189 Desflurane Thumb
13 Investigational SmallMoleculeDrug DB05087 Ganaxolone Thumb
14 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb
15 Approved;
Illicit		 SmallMoleculeDrug DB01215 Estazolam Thumb
16 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
17 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB00801 Halazepam Thumb
18 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb
19 Approved SmallMoleculeDrug DB01594 Cinolazepam Thumb
20 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb
21 Illicit SmallMoleculeDrug DB01483 Barbital Thumb
22 Approved;
Illicit		 SmallMoleculeDrug DB01559 Clotiazepam Thumb
23 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb
24 Approved SmallMoleculeDrug DB00546 Adinazolam Thumb
25 Approved;
Illicit		 SmallMoleculeDrug DB00349 Clobazam Thumb
26 Approved;
Illicit		 SmallMoleculeDrug DB00683 Midazolam Thumb
27 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb
28 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb
29 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00475 Chlordiazepoxide Thumb
30 Approved;
Vet approved		 SmallMoleculeDrug DB00794 Primidone Thumb
31 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb
32 Approved SmallMoleculeDrug DB00849 Methylphenobarbital Thumb
33 Approved SmallMoleculeDrug DB00842 Oxazepam Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB00897 Triazolam Thumb
35 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb
36 Approved SmallMoleculeDrug DB01354 Heptabarbital Thumb
37 Approved;
Illicit		 SmallMoleculeDrug DB00628 Clorazepate Thumb
38 Approved SmallMoleculeDrug DB13872 Lormetazepam Thumb
39 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb
40 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB01558 Bromazepam Thumb
41 Approved;
Illicit		 SmallMoleculeDrug DB01544 Flunitrazepam Thumb
42 Approved;
Investigational		 SmallMoleculeDrug DB00402 Eszopiclone Thumb
43 Approved;
Vet approved		 SmallMoleculeDrug DB00599 Thiopental Thumb
44 Approved SmallMoleculeDrug DB09118 Stiripentol Thumb
45 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb
46 Experimental;
Illicit		 SmallMoleculeDrug DB01496 Barbituric acid derivative Thumb
47 Approved SmallMoleculeDrug DB00273 Topiramate Thumb
48 Approved SmallMoleculeDrug DB00292 Etomidate Thumb
49 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
50 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB00189 Ethchlorvynol Thumb
51 Approved SmallMoleculeDrug DB00186 Lorazepam Thumb
52 Approved SmallMoleculeDrug DB01198 Zopiclone Thumb
53 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb
54 Approved;
Investigational		 SmallMoleculeDrug DB00231 Temazepam Thumb
55 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00690 Flurazepam Thumb
56 Approved;
Investigational		 SmallMoleculeDrug DB11582 Thiocolchicoside Thumb
57 Approved;
Illicit		 SmallMoleculeDrug DB01068 Clonazepam Thumb
58 Approved;
Illicit		 SmallMoleculeDrug DB01353 Butethal Thumb
59 Experimental SmallMoleculeDrug DB13983 5,7,2′-trihydroxy-6,8-dimethoxyflavone Thumb
60 Approved;
Illicit		 SmallMoleculeDrug DB01437 Glutethimide Thumb
61 Approved;
Illicit		 SmallMoleculeDrug DB00371 Meprobamate Thumb
62 Approved SmallMoleculeDrug DB01595 Nitrazepam Thumb
63 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00829 Diazepam Thumb
64 Approved SmallMoleculeDrug DB01205 Flumazenil Thumb
65 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
66 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB01107 Methyprylon Thumb
67 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
68 Approved;
Illicit		 SmallMoleculeDrug DB01351 Amobarbital Thumb
69 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb


20 predicted interactions (drugs) of input target (GABRA5): Gamma-aminobutyric acid receptor subunit alpha-5
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00425 Zolpidem Thumb 91.7%
2 Approved SmallMoleculeDrug DB01587 Ketazolam Thumb 90.0%
3 Approved SmallMoleculeDrug DB09166 Etizolam Thumb 89.1%
4 Approved SmallMoleculeDrug DB01346 Quinidine barbiturate Thumb 86.2%
5 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 86.1%
6 Investigational SmallMoleculeDrug DB04903 Pagoclone Thumb 83.6%
7 Investigational SmallMoleculeDrug DB13994 AZD-7325 Thumb 82.6%
8 Approved SmallMoleculeDrug DB00395 Carisoprodol Thumb 81.2%
9 Investigational SmallMoleculeDrug DB12458 Muscimol Thumb 81.0%
10 Experimental SmallMoleculeDrug DB00466 Picrotoxin Thumb 78.2%
11 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB06716 Fospropofol Thumb 73.8%
12 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb 72.2%
13 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00962 Zaleplon Thumb 72.0%
14 Approved;
Investigational		 SmallMoleculeDrug DB01174 Phenobarbital Thumb 70.9%
15 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00602 Ivermectin Thumb 67.6%
16 Approved;
Vet approved		 SmallMoleculeDrug DB00592 Piperazine Thumb 66.1%
17 Approved;
Investigational		 SmallMoleculeDrug DB00837 Progabide Thumb 65.7%
18 Investigational SmallMoleculeDrug DB06470 clomethiazole Thumb 65.6%
19 Experimental SmallMoleculeDrug DB01341 Dihydroquinidine barbiturate Thumb 64.8%
20 Approved;
Vet approved		 SmallMoleculeDrug DB01154 Thiamylal Thumb 62.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.