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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P06737
No. Gene UniProt ID Protein Name Pathway PDB
1 PYGL P06737 Glycogen phosphorylase, liver form hsa00500; hsa01100; hsa04217; hsa04910; hsa04922; hsa04931 1EM6; 1EXV; 1FA9; 1FC0; 1L5Q; 1L5R; 1L5S; 1L7X; 1XOI; 2ATI; 2QLL; 2ZB2; 3CEH; 3CEJ; 3CEM; 3DD1; 3DDS; 3DDW

15 known interactions (drugs) of input target (PYGL): Glycogen phosphorylase, liver form
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB02320 1-N-Acetyl-Beta-D-Glucosamine Thumb
2 Approved;
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb
3 Experimental SmallMoleculeDrug DB04522 Dexfosfoserine Thumb
4 Experimental SmallMoleculeDrug DB03288 5-Chloro-1h-Indole-2-Carboxylic Acid{[Cyclopentyl-(2-Hydroxy-Ethyl)-Carbamoyl]-Methyl}-Amide Thumb
5 Experimental SmallMoleculeDrug DB07395 4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid Thumb
6 Experimental SmallMoleculeDrug DB07396 1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid Thumb
7 Approved;
SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb
8 Experimental SmallMoleculeDrug DB07315 5-chloro-N-{4-[(1R)-1,2-dihydroxyethyl]phenyl}-1H-indole-2-carboxamide Thumb
9 Experimental SmallMoleculeDrug DB03744 Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-Carboxylate Thumb
10 Experimental SmallMoleculeDrug DB07968 N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREA Thumb
11 Experimental;
SmallMoleculeDrug DB08844 Uric Acid Thumb
12 Experimental SmallMoleculeDrug DB02379 Beta-D-Glucose Thumb
13 Investigational SmallMoleculeDrug DB05044 PSN357 Thumb
14 Experimental SmallMoleculeDrug DB02089 CP-526423 Thumb
15 Experimental;
SmallMoleculeDrug DB03496 Alvocidib Thumb

20 predicted interactions (drugs) of input target (PYGL): Glycogen phosphorylase, liver form
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB11638 Artenimol Thumb 32.7%
2 Experimental SmallMoleculeDrug DB04083 N'-Pyridoxyl-Lysine-5'-Monophosphate Thumb 28.6%
3 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 27.6%
4 Approved;
SmallMoleculeDrug DB00908 Quinidine Thumb 26.4%
5 Approved;
SmallMoleculeDrug DB01074 Perhexiline Thumb 26.3%
6 Experimental SmallMoleculeDrug DB04396 Thiodigalactoside Thumb 26.0%
7 Approved SmallMoleculeDrug DB00201 Caffeine Thumb 24.6%
8 Approved;
SmallMoleculeDrug DB00133 Serine Thumb 24.3%
9 Experimental SmallMoleculeDrug DB02451 B-nonylglucoside Thumb 24.2%
10 Experimental SmallMoleculeDrug DB02471 Nojirimycine Tetrazole Thumb 24.2%
11 Approved BiotechDrug DB10770 Foreskin fibroblast (neonatal) Thumb 23.6%
12 Experimental SmallMoleculeDrug DB03256 (6R)-Folinic acid Thumb 23.6%
13 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb 23.1%
14 Approved;
SmallMoleculeDrug DB09073 Palbociclib Thumb 22.9%
15 Experimental SmallMoleculeDrug DB08322 2-DEOXY-3,4-BIS-O-[3-(4-HYDROXYPHENYL)PROPANOYL]-L-THREO-PENTARIC ACID Thumb 22.9%
16 Experimental SmallMoleculeDrug DB08222 METHOXYUNDECYLPHOSPHINIC ACID Thumb 22.9%
17 Approved;
SmallMoleculeDrug DB03929 D-Serine Thumb 22.4%
18 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb 22.1%
19 Experimental SmallMoleculeDrug DB02506 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid Thumb 21.9%
20 Experimental SmallMoleculeDrug DB04645 5-{3-[3-(2,4-DICHLORO-BENZOYL)-UREIDO]-2-METHYL-PHENOXY}-PENTANOIC ACID Thumb 21.6%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.