QuartataWeb 1.0

17 known interactions (drugs) of input target (VEGFA): Vascular endothelial growth factor A

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter
1	Approved	SmallMoleculeDrug	DB05294	Vandetanib	COC1=C(OCC2CCN(C)CC2)C=C2N=CN=C(NC3=C(F)C=C(Br)C=C3)C2=C1
2	Approved; Investigational; Nutraceutical	SmallMoleculeDrug	DB09301	Chondroitin sulfate	NA
3	Approved; Investigational	BiotechDrug	DB00112	Bevacizumab	NA
4	Investigational	SmallMoleculeDrug	DB05932	Denibulin	[H][C@@](C)(N)C(=O)NC1=CC=C(SC2=CC3=C(C=C2)N=C(N3)N=C(O)OC)C=C1
5	Approved	BiotechDrug	DB10772	Foreskin keratinocyte (neonatal)	NA
6	Investigational	BiotechDrug	DB06642	Bevasiranib	NA
7	Approved	SmallMoleculeDrug	DB03754	Tromethamine	NC(CO)(CO)CO
8	Approved	SmallMoleculeDrug	DB06779	Dalteparin	NA
9	Approved; Investigational	SmallMoleculeDrug	DB01136	Carvedilol	COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=CC=CC=C1N2
10	Approved	BiotechDrug	DB08885	Aflibercept	NA
11	Investigational	SmallMoleculeDrug	DB05890	VEGF-AS	NA
12	Approved; Investigational	SmallMoleculeDrug	DB03088	Pidolic Acid	OC(=O)[C@@H]1CCC(=O)N1
13	Approved	BiotechDrug	DB01270	Ranibizumab	NA
14	Investigational	SmallMoleculeDrug	DB05969	SNS-032	CC(C)(C)C1=CN=C(CSC2=CN=C(NC(=O)C3CCNCC3)S2)O1
15	Approved	SmallMoleculeDrug	DB01120	Gliclazide	CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NN1CC2CCCC2C1
16	Approved; Investigational	SmallMoleculeDrug	DB01017	Minocycline	[H][C@@]12CC3=C(C(O)=CC=C3N(C)C)C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2
17	Investigational	SmallMoleculeDrug	DB05434	ABT-510	CCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)CN(C)C(C)=O)C(C)C)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)NCC

20 predicted interactions (drugs) of input target (VEGFA): Vascular endothelial growth factor A

No.	Group	Type	Drug ID	Drug Name	SMILES ⇨ TargetHunter	Confidence score
1	Approved; Investigational; Nutraceutical	SmallMoleculeDrug	DB00143	Glutathione	N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O	39.9%
2	Approved	BiotechDrug	DB00054	Abciximab	NA	32.4%
3	Approved; Investigational	SmallMoleculeDrug	DB05676	Apremilast	[H][C@](CS(C)(=O)=O)(N1C(=O)C2=C(C1=O)C(=CC=C2)N=C(C)O)C1=CC(OCC)=C(OC)C=C1	32.1%
4	Approved; Investigational; Vet approved	SmallMoleculeDrug	DB00091	Cyclosporine	CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C	29.3%
5	Approved; Investigational	BiotechDrug	DB00081	Tositumomab	NA	28.5%
6	Approved; Investigational	SmallMoleculeDrug	DB09462	Glycerin	OCC(O)CO	28.4%
7	Approved; Nutraceutical	SmallMoleculeDrug	DB13961	Fish oil	NA	28.0%
8	Investigational; Withdrawn	BiotechDrug	DB00111	Daclizumab	NA	28.0%
9	Approved	BiotechDrug	DB00051	Adalimumab	NA	27.3%
10	Approved; Investigational	BiotechDrug	DB00075	Muromonab	NA	26.6%
11	Approved	BiotechDrug	DB00002	Cetuximab	NA	26.3%
12	Approved; Investigational	BiotechDrug	DB00108	Natalizumab	NA	25.6%
13	Approved	BiotechDrug	DB10770	Foreskin fibroblast (neonatal)	NA	25.4%
14	Approved; Nutraceutical	SmallMoleculeDrug	DB00132	Alpha-Linolenic Acid	CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O	25.2%
15	Approved	SmallMoleculeDrug	DB00675	Tamoxifen	CC\C(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1	25.0%
16	Approved; Withdrawn	SmallMoleculeDrug	DB09121	Aurothioglucose	OC[C@H]1O[C@H](S[Au])[C@H](O)[C@@H](O)[C@@H]1O	24.8%
17	Approved	BiotechDrug	DB00073	Rituximab	NA	24.4%
18	Experimental; Investigational	SmallMoleculeDrug	DB02587	Colforsin	[H][C@]1(O)CCC(C)(C)[C@]2([H])[C@]([H])(O)[C@]([H])(OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)[C@]3(O)[C@@]12C)C=C	24.0%
19	Experimental	SmallMoleculeDrug	DB04557	Arachidonic Acid	CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O	23.7%
20	Approved; Investigational; Nutraceutical	SmallMoleculeDrug	DB00114	Pyridoxal Phosphate	CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O	23.6%