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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P48169
No. Gene UniProt ID Protein Name Pathway PDB
1 GABRA4 P48169 Gamma-aminobutyric acid receptor subunit alpha-4 hsa04080; hsa04723; hsa04727; hsa04742; hsa05032; hsa05033 NA


63 known interactions (drugs) of input target (GABRA4): Gamma-aminobutyric acid receptor subunit alpha-4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb
2 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb
3 Approved;
Illicit		 SmallMoleculeDrug DB01352 Aprobarbital Thumb
4 Approved;
Illicit		 SmallMoleculeDrug DB01588 Prazepam Thumb
5 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00404 Alprazolam Thumb
6 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb
7 Investigational SmallMoleculeDrug DB06579 Adipiplon Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB11901 Apalutamide Thumb
9 Approved SmallMoleculeDrug DB01355 Hexobarbital Thumb
10 Approved SmallMoleculeDrug DB01189 Desflurane Thumb
11 Investigational SmallMoleculeDrug DB05087 Ganaxolone Thumb
12 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00312 Pentobarbital Thumb
13 Approved;
Illicit		 SmallMoleculeDrug DB01215 Estazolam Thumb
14 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
15 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB00801 Halazepam Thumb
16 Approved;
Illicit		 SmallMoleculeDrug DB00237 Butabarbital Thumb
17 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01028 Methoxyflurane Thumb
18 Illicit SmallMoleculeDrug DB01483 Barbital Thumb
19 Approved;
Illicit		 SmallMoleculeDrug DB01589 Quazepam Thumb
20 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00228 Enflurane Thumb
21 Approved;
Illicit		 SmallMoleculeDrug DB00349 Clobazam Thumb
22 Approved;
Illicit		 SmallMoleculeDrug DB00683 Midazolam Thumb
23 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb
24 Approved;
Vet approved		 SmallMoleculeDrug DB00418 Secobarbital Thumb
25 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00475 Chlordiazepoxide Thumb
26 Approved;
Vet approved		 SmallMoleculeDrug DB00794 Primidone Thumb
27 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb
28 Approved SmallMoleculeDrug DB00849 Methylphenobarbital Thumb
29 Approved SmallMoleculeDrug DB00842 Oxazepam Thumb
30 Approved;
Investigational		 SmallMoleculeDrug DB00897 Triazolam Thumb
31 Approved;
Investigational		 SmallMoleculeDrug DB00659 Acamprosate Thumb
32 Approved SmallMoleculeDrug DB01354 Heptabarbital Thumb
33 Approved;
Illicit		 SmallMoleculeDrug DB00628 Clorazepate Thumb
34 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00829 Diazepam Thumb
35 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01708 Prasterone Thumb
36 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB01558 Bromazepam Thumb
37 Approved;
Illicit		 SmallMoleculeDrug DB01544 Flunitrazepam Thumb
38 Approved;
Investigational		 SmallMoleculeDrug DB00402 Eszopiclone Thumb
39 Approved;
Vet approved		 SmallMoleculeDrug DB00599 Thiopental Thumb
40 Approved SmallMoleculeDrug DB09118 Stiripentol Thumb
41 Approved;
Vet approved		 SmallMoleculeDrug DB01236 Sevoflurane Thumb
42 Experimental;
Illicit		 SmallMoleculeDrug DB01496 Barbituric acid derivative Thumb
43 Approved SmallMoleculeDrug DB00273 Topiramate Thumb
44 Approved SmallMoleculeDrug DB00292 Etomidate Thumb
45 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
46 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB00189 Ethchlorvynol Thumb
47 Approved SmallMoleculeDrug DB00186 Lorazepam Thumb
48 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb
49 Approved;
Illicit		 SmallMoleculeDrug DB01353 Butethal Thumb
50 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00690 Flurazepam Thumb
51 Approved;
Investigational		 SmallMoleculeDrug DB11582 Thiocolchicoside Thumb
52 Approved;
Illicit		 SmallMoleculeDrug DB01068 Clonazepam Thumb
53 Approved;
Investigational		 SmallMoleculeDrug DB00231 Temazepam Thumb
54 Experimental SmallMoleculeDrug DB13983 5,7,2′-trihydroxy-6,8-dimethoxyflavone Thumb
55 Approved;
Illicit		 SmallMoleculeDrug DB01437 Glutethimide Thumb
56 Approved;
Illicit		 SmallMoleculeDrug DB00371 Meprobamate Thumb
57 Approved SmallMoleculeDrug DB01595 Nitrazepam Thumb
58 Approved SmallMoleculeDrug DB01205 Flumazenil Thumb
59 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb
60 Approved;
Illicit;
Withdrawn		 SmallMoleculeDrug DB01107 Methyprylon Thumb
61 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
62 Approved;
Illicit		 SmallMoleculeDrug DB01351 Amobarbital Thumb
63 Approved;
Illicit		 SmallMoleculeDrug DB00306 Talbutal Thumb


20 predicted interactions (drugs) of input target (GABRA4): Gamma-aminobutyric acid receptor subunit alpha-4
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Illicit		 SmallMoleculeDrug DB01567 Fludiazepam Thumb 92.8%
2 Approved SmallMoleculeDrug DB00546 Adinazolam Thumb 92.4%
3 Approved;
Illicit		 SmallMoleculeDrug DB01559 Clotiazepam Thumb 92.2%
4 Approved SmallMoleculeDrug DB01594 Cinolazepam Thumb 92.2%
5 Approved SmallMoleculeDrug DB00425 Zolpidem Thumb 90.7%
6 Approved SmallMoleculeDrug DB01587 Ketazolam Thumb 89.8%
7 Approved SmallMoleculeDrug DB13872 Lormetazepam Thumb 89.6%
8 Approved SmallMoleculeDrug DB01198 Zopiclone Thumb 86.6%
9 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB01381 Ginkgo biloba Thumb 86.4%
10 Approved SmallMoleculeDrug DB09166 Etizolam Thumb 85.1%
11 Approved SmallMoleculeDrug DB01346 Quinidine barbiturate Thumb 83.0%
12 Investigational SmallMoleculeDrug DB04903 Pagoclone Thumb 79.2%
13 Investigational SmallMoleculeDrug DB12458 Muscimol Thumb 78.9%
14 Approved SmallMoleculeDrug DB00395 Carisoprodol Thumb 78.7%
15 Investigational SmallMoleculeDrug DB13994 AZD-7325 Thumb 77.1%
16 Experimental SmallMoleculeDrug DB00466 Picrotoxin Thumb 73.5%
17 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb 71.8%
18 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB06716 Fospropofol Thumb 71.4%
19 Approved;
Investigational		 SmallMoleculeDrug DB01174 Phenobarbital Thumb 68.6%
20 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00962 Zaleplon Thumb 68.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.