QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P48443
No. Gene UniProt ID Protein Name Pathway PDB
1 RXRG P48443 Retinoic acid receptor RXR-gamma hsa03320; hsa04659; hsa04919; hsa04920; hsa04928; hsa05200; hsa05202; hsa05216; hsa05222; hsa05223; hsa05226 2GL8


10 known interactions (drugs) of input target (RXRG): Retinoic acid receptor RXR-gamma
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB00307 Bexarotene Thumb
2 Withdrawn SmallMoleculeDrug DB00926 Etretinate Thumb
3 Approved SmallMoleculeDrug DB00210 Adapalene Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00523 Alitretinoin Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB03756 Doconexent Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB01393 Bezafibrate Thumb
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB00412 Rosiglitazone Thumb
9 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb
10 Approved SmallMoleculeDrug DB00459 Acitretin Thumb


20 predicted interactions (drugs) of input target (RXRG): Retinoic acid receptor RXR-gamma
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00799 Tazarotene Thumb 55.2%
2 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB04224 Oleic Acid Thumb 41.0%
3 Investigational SmallMoleculeDrug DB05785 LGD-1550 Thumb 40.4%
4 Experimental SmallMoleculeDrug DB01941 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid Thumb 39.6%
5 Experimental SmallMoleculeDrug DB07863 2-chloro-5-nitro-N-phenylbenzamide Thumb 38.4%
6 Experimental SmallMoleculeDrug DB08402 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Thumb 38.1%
7 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb 37.4%
8 Approved;
Nutraceutical		 SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb 34.7%
9 Experimental SmallMoleculeDrug DB08601 tributylstannanyl Thumb 34.3%
10 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb 33.8%
11 Experimental SmallMoleculeDrug DB08175 (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Thumb 33.1%
12 Experimental SmallMoleculeDrug DB07080 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Thumb 32.7%
13 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00749 Etodolac Thumb 32.5%
14 Experimental SmallMoleculeDrug DB07929 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE Thumb 32.5%
15 Experimental SmallMoleculeDrug DB08063 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE Thumb 32.1%
16 Investigational SmallMoleculeDrug DB05956 EVT-101 Thumb 31.8%
17 Approved SmallMoleculeDrug DB00982 Isotretinoin Thumb 31.2%
18 Approved;
Investigational		 SmallMoleculeDrug DB04942 Tamibarotene Thumb 30.6%
19 Experimental SmallMoleculeDrug DB07557 (5BETA)-PREGNANE-3,20-DIONE Thumb 29.8%
20 Approved;
Nutraceutical		 SmallMoleculeDrug DB01436 Alfacalcidol Thumb 27.1%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.