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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P50416
No. Gene UniProt ID Protein Name Pathway PDB
1 CPT1A P50416 Carnitine O-palmitoyltransferase 1, liver isoform hsa00071; hsa01212; hsa03320; hsa04152; hsa04714; hsa04920; hsa04922; hsa04931 2LE3


3 known interactions (drugs) of input target (CPT1A): Carnitine O-palmitoyltransferase 1, liver isoform
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved SmallMoleculeDrug DB01016 Glyburide Thumb
2 Approved;
Investigational
SmallMoleculeDrug DB01074 Perhexiline Thumb
3 Approved;
Investigational
SmallMoleculeDrug DB00583 L-Carnitine Thumb


20 predicted interactions (drugs) of input target (CPT1A): Carnitine O-palmitoyltransferase 1, liver isoform
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
Nutraceutical
SmallMoleculeDrug DB00142 Glutamic Acid Thumb 25.0%
2 Approved;
Investigational
SmallMoleculeDrug DB09220 Nicorandil Thumb 24.2%
3 Approved;
Vet approved
SmallMoleculeDrug DB01154 Thiamylal Thumb 23.8%
4 Investigational;
Nutraceutical
SmallMoleculeDrug DB00171 ATP Thumb 23.7%
5 Experimental SmallMoleculeDrug DB02648 (3-Carboxy-2-(R)-Hydroxy-Propyl)-Trimethyl-Ammonium Thumb 20.2%
6 Approved;
Investigational
SmallMoleculeDrug DB00845 Clofazimine Thumb 18.8%
7 Approved;
Investigational
SmallMoleculeDrug DB01599 Probucol Thumb 18.5%
8 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb 17.5%
9 Approved;
Investigational
SmallMoleculeDrug DB01251 Gliquidone Thumb 17.4%
10 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 17.2%
11 Approved;
Investigational
SmallMoleculeDrug DB12965 Silver Thumb 16.5%
12 Approved;
Illicit
SmallMoleculeDrug DB00907 Cocaine Thumb 16.3%
13 Experimental SmallMoleculeDrug DB01694 D-tartaric acid Thumb 16.2%
14 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb 15.9%
15 Approved;
Investigational
SmallMoleculeDrug DB01175 Escitalopram Thumb 15.6%
16 Approved SmallMoleculeDrug DB00434 Cyproheptadine Thumb 15.3%
17 Approved;
Investigational
SmallMoleculeDrug DB00839 Tolazamide Thumb 14.8%
18 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB00174 L-Asparagine Thumb 14.7%
19 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB00914 Phenformin Thumb 14.5%
20 Experimental SmallMoleculeDrug DB08259 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID Thumb 14.4%



  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.