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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P28702
No. Gene UniProt ID Protein Name Pathway PDB
1 RXRB P28702 Retinoic acid receptor RXR-beta hsa03320; hsa04659; hsa04919; hsa04920; hsa04928; hsa05200; hsa05202; hsa05216; hsa05222; hsa05223; hsa05226 1H9U; 1UHL


15 known interactions (drugs) of input target (RXRB): Retinoic acid receptor RXR-beta
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB00307 Bexarotene Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB03756 Doconexent Thumb
3 Experimental SmallMoleculeDrug DB08175 (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID Thumb
4 Withdrawn SmallMoleculeDrug DB00926 Etretinate Thumb
5 Approved;
Investigational		 SmallMoleculeDrug DB00523 Alitretinoin Thumb
6 Approved SmallMoleculeDrug DB00210 Adapalene Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB00412 Rosiglitazone Thumb
8 Experimental SmallMoleculeDrug DB01941 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid Thumb
9 Approved;
Investigational		 SmallMoleculeDrug DB00799 Tazarotene Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB01393 Bezafibrate Thumb
11 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb
12 Experimental SmallMoleculeDrug DB07929 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE Thumb
13 Experimental SmallMoleculeDrug DB07080 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Thumb
14 Experimental SmallMoleculeDrug DB02746 Phthalic Acid Thumb
15 Approved SmallMoleculeDrug DB00459 Acitretin Thumb


20 predicted interactions (drugs) of input target (RXRB): Retinoic acid receptor RXR-beta
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Investigational SmallMoleculeDrug DB05785 LGD-1550 Thumb 43.4%
2 Experimental SmallMoleculeDrug DB07863 2-chloro-5-nitro-N-phenylbenzamide Thumb 39.3%
3 Experimental SmallMoleculeDrug DB08063 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE Thumb 38.1%
4 Experimental SmallMoleculeDrug DB07557 (5BETA)-PREGNANE-3,20-DIONE Thumb 37.5%
5 Experimental SmallMoleculeDrug DB08402 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Thumb 36.2%
6 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb 34.7%
7 Approved SmallMoleculeDrug DB00982 Isotretinoin Thumb 32.9%
8 Experimental SmallMoleculeDrug DB04557 Arachidonic Acid Thumb 32.4%
9 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB04224 Oleic Acid Thumb 31.2%
10 Experimental SmallMoleculeDrug DB02877 Arotinoid acid Thumb 29.6%
11 Experimental SmallMoleculeDrug DB08601 tributylstannanyl Thumb 29.3%
12 Approved SmallMoleculeDrug DB03147 Flavin adenine dinucleotide Thumb 28.5%
13 Approved;
Nutraceutical		 SmallMoleculeDrug DB00132 Alpha-Linolenic Acid Thumb 28.0%
14 Approved;
Investigational		 SmallMoleculeDrug DB04942 Tamibarotene Thumb 27.3%
15 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 26.7%
16 Experimental SmallMoleculeDrug DB03600 Capric acid Thumb 26.0%
17 Approved;
Vet approved		 SmallMoleculeDrug DB00396 Progesterone Thumb 26.0%
18 Experimental SmallMoleculeDrug DB02258 SR11254 Thumb 25.5%
19 Approved;
Investigational		 SmallMoleculeDrug DB05389 Tetrachlorodecaoxide Thumb 24.9%
20 Experimental SmallMoleculeDrug DB03466 BMS184394 Thumb 24.5%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.