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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P14867
No. Gene UniProt ID Protein Name Pathway PDB
1 GABRA1 P14867 Gamma-aminobutyric acid receptor subunit alpha-1 hsa04080; hsa04723; hsa04727; hsa04742; hsa05032; hsa05033 NA


84 known interactions (drugs) of input target (GABRA1): Gamma-aminobutyric acid receptor subunit alpha-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00818 Propofol Thumb
2 Approved;
Nutraceutical
SmallMoleculeDrug DB01956 Taurine Thumb
3 Approved;
Illicit
SmallMoleculeDrug DB00349 Clobazam Thumb
4 Approved;
Illicit
SmallMoleculeDrug DB01352 Aprobarbital Thumb
5 Approved;
Illicit
SmallMoleculeDrug DB01589 Quazepam Thumb
6 Approved;
Illicit
SmallMoleculeDrug DB01588 Prazepam Thumb
7 Investigational SmallMoleculeDrug DB12458 Muscimol Thumb
8 Approved;
Illicit;
Investigational
SmallMoleculeDrug DB00404 Alprazolam Thumb
9 Withdrawn SmallMoleculeDrug DB00463 Metharbital Thumb
10 Approved SmallMoleculeDrug DB09166 Etizolam Thumb
11 Investigational SmallMoleculeDrug DB06579 Adipiplon Thumb
12 Approved;
Investigational
SmallMoleculeDrug DB11901 Apalutamide Thumb
13 Approved;
Illicit
SmallMoleculeDrug DB01567 Fludiazepam Thumb
14 Approved SmallMoleculeDrug DB01355 Hexobarbital Thumb
15 Approved SmallMoleculeDrug DB01189 Desflurane Thumb
16 Investigational SmallMoleculeDrug DB05087 Ganaxolone Thumb
17 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00312 Pentobarbital Thumb
18 Approved;
Illicit
SmallMoleculeDrug DB01215 Estazolam Thumb
19 Approved SmallMoleculeDrug DB00425 Zolpidem Thumb
20 Approved SmallMoleculeDrug DB00898 Ethanol Thumb
21 Approved;
Illicit;
Withdrawn
SmallMoleculeDrug DB00801 Halazepam Thumb
22 Approved;
Investigational
SmallMoleculeDrug DB01174 Phenobarbital Thumb
23 Approved;
Illicit
SmallMoleculeDrug DB00237 Butabarbital Thumb
24 Approved SmallMoleculeDrug DB01594 Cinolazepam Thumb
25 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB01028 Methoxyflurane Thumb
26 Illicit SmallMoleculeDrug DB01483 Barbital Thumb
27 Approved;
Illicit
SmallMoleculeDrug DB01559 Clotiazepam Thumb
28 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00228 Enflurane Thumb
29 Approved SmallMoleculeDrug DB00546 Adinazolam Thumb
30 Investigational SmallMoleculeDrug DB06470 clomethiazole Thumb
31 Approved SmallMoleculeDrug DB01587 Ketazolam Thumb
32 Approved;
Illicit
SmallMoleculeDrug DB00683 Midazolam Thumb
33 Approved;
Illicit
SmallMoleculeDrug DB00241 Butalbital Thumb
34 Approved;
Vet approved
SmallMoleculeDrug DB00418 Secobarbital Thumb
35 Approved;
Illicit;
Investigational
SmallMoleculeDrug DB00475 Chlordiazepoxide Thumb
36 Approved;
Vet approved
SmallMoleculeDrug DB00794 Primidone Thumb
37 Approved;
Vet approved
SmallMoleculeDrug DB01159 Halothane Thumb
38 Approved SmallMoleculeDrug DB00849 Methylphenobarbital Thumb
39 Approved;
Illicit
SmallMoleculeDrug DB01353 Butethal Thumb
40 Approved SmallMoleculeDrug DB00842 Oxazepam Thumb
41 Experimental SmallMoleculeDrug DB01341 Dihydroquinidine barbiturate Thumb
42 Approved;
Investigational
SmallMoleculeDrug DB00897 Triazolam Thumb
43 Approved;
Investigational
SmallMoleculeDrug DB00659 Acamprosate Thumb
44 Approved SmallMoleculeDrug DB01354 Heptabarbital Thumb
45 Approved;
Illicit
SmallMoleculeDrug DB00628 Clorazepate Thumb
46 Approved SmallMoleculeDrug DB13872 Lormetazepam Thumb
47 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01708 Prasterone Thumb
48 Approved;
Illicit;
Investigational
SmallMoleculeDrug DB01558 Bromazepam Thumb
49 Approved;
Illicit
SmallMoleculeDrug DB01544 Flunitrazepam Thumb
50 Approved SmallMoleculeDrug DB01346 Quinidine barbiturate Thumb
51 Approved;
Investigational
SmallMoleculeDrug DB00402 Eszopiclone Thumb
52 Approved;
Vet approved
SmallMoleculeDrug DB00599 Thiopental Thumb
53 Experimental SmallMoleculeDrug DB00466 Picrotoxin Thumb
54 Approved;
Investigational
SmallMoleculeDrug DB00837 Progabide Thumb
55 Approved SmallMoleculeDrug DB09118 Stiripentol Thumb
56 Approved;
Vet approved
SmallMoleculeDrug DB01236 Sevoflurane Thumb
57 Experimental;
Illicit
SmallMoleculeDrug DB01496 Barbituric acid derivative Thumb
58 Approved SmallMoleculeDrug DB00273 Topiramate Thumb
59 Approved;
Vet approved
SmallMoleculeDrug DB01154 Thiamylal Thumb
60 Approved SmallMoleculeDrug DB00292 Etomidate Thumb
61 Approved;
Investigational
SmallMoleculeDrug DB00555 Lamotrigine Thumb
62 Approved;
Illicit;
Withdrawn
SmallMoleculeDrug DB00189 Ethchlorvynol Thumb
63 Approved SmallMoleculeDrug DB00186 Lorazepam Thumb
64 Approved SmallMoleculeDrug DB01198 Zopiclone Thumb
65 Approved SmallMoleculeDrug DB00474 Methohexital Thumb
66 Approved;
Illicit;
Investigational
SmallMoleculeDrug DB00962 Zaleplon Thumb
67 Approved;
Vet approved
SmallMoleculeDrug DB00753 Isoflurane Thumb
68 Approved SmallMoleculeDrug DB00395 Carisoprodol Thumb
69 Approved;
Illicit;
Investigational;
Vet approved
SmallMoleculeDrug DB00829 Diazepam Thumb
70 Approved;
Illicit;
Investigational
SmallMoleculeDrug DB00690 Flurazepam Thumb
71 Approved;
Investigational
SmallMoleculeDrug DB11582 Thiocolchicoside Thumb
72 Approved;
Illicit
SmallMoleculeDrug DB01068 Clonazepam Thumb
73 Approved;
Investigational
SmallMoleculeDrug DB00231 Temazepam Thumb
74 Experimental SmallMoleculeDrug DB13983 5,7,2′-trihydroxy-6,8-dimethoxyflavone Thumb
75 Approved;
Illicit
SmallMoleculeDrug DB01437 Glutethimide Thumb
76 Approved;
Illicit
SmallMoleculeDrug DB00371 Meprobamate Thumb
77 Approved SmallMoleculeDrug DB01595 Nitrazepam Thumb
78 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB01381 Ginkgo biloba Thumb
79 Approved SmallMoleculeDrug DB01205 Flumazenil Thumb
80 Approved;
Investigational
SmallMoleculeDrug DB00334 Olanzapine Thumb
81 Approved;
Illicit;
Withdrawn
SmallMoleculeDrug DB01107 Methyprylon Thumb
82 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
83 Approved;
Illicit
SmallMoleculeDrug DB01351 Amobarbital Thumb
84 Approved;
Illicit
SmallMoleculeDrug DB00306 Talbutal Thumb


20 predicted interactions (drugs) of input target (GABRA1): Gamma-aminobutyric acid receptor subunit alpha-1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Investigational SmallMoleculeDrug DB04903 Pagoclone Thumb 86.4%
2 Investigational SmallMoleculeDrug DB13994 AZD-7325 Thumb 84.5%
3 Approved;
Withdrawn
SmallMoleculeDrug DB00431 Lindane Thumb 75.8%
4 Approved;
Illicit;
Investigational
SmallMoleculeDrug DB06716 Fospropofol Thumb 73.8%
5 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB00602 Ivermectin Thumb 71.9%
6 Approved;
Vet approved
SmallMoleculeDrug DB00592 Piperazine Thumb 67.4%
7 Approved;
Illicit;
Investigational
SmallMoleculeDrug DB01440 Gamma Hydroxybutyric Acid Thumb 57.6%
8 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB01178 Chlormezanone Thumb 43.0%
9 Experimental SmallMoleculeDrug DB02999 Quisqualate Thumb 41.0%
10 Experimental SmallMoleculeDrug DB02852 Domoic Acid Thumb 39.3%
11 Approved;
Experimental;
Investigational
SmallMoleculeDrug DB03929 D-Serine Thumb 38.7%
12 Approved;
Vet approved
SmallMoleculeDrug DB00572 Atropine Thumb 37.8%
13 Experimental SmallMoleculeDrug DB03425 2s,4r-4-Methylglutamate Thumb 34.4%
14 Experimental SmallMoleculeDrug DB04599 Aniracetam Thumb 33.7%
15 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 32.9%
16 Approved SmallMoleculeDrug DB00915 Amantadine Thumb 32.0%
17 Approved;
Investigational
SmallMoleculeDrug DB01043 Memantine Thumb 30.2%
18 Approved SmallMoleculeDrug DB00454 Pethidine Thumb 30.1%
19 Experimental SmallMoleculeDrug DB02057 (S)-AMPA Thumb 30.0%
20 Approved;
Nutraceutical
SmallMoleculeDrug DB14006 Choline salicylate Thumb 29.5%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.