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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q99250
No. Gene UniProt ID Protein Name Pathway PDB
1 SCN2A Q99250 Sodium channel protein type 2 subunit alpha hsa04742 2KAV; 4JPZ


8 known interactions (drugs) of input target (SCN2A): Sodium channel protein type 2 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00818 Propofol Thumb
2 Approved SmallMoleculeDrug DB13269 Dichlorobenzyl alcohol Thumb
3 Approved;
Investigational		 SmallMoleculeDrug DB00909 Zonisamide Thumb
4 Approved;
Investigational		 SmallMoleculeDrug DB00313 Valproic Acid Thumb
5 Investigational SmallMoleculeDrug DB05232 Tetrodotoxin Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb
7 Approved;
Investigational		 SmallMoleculeDrug DB05541 Brivaracetam Thumb
8 Experimental SmallMoleculeDrug DB13520 Metergoline Thumb


20 predicted interactions (drugs) of input target (SCN2A): Sodium channel protein type 2 subunit alpha
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved SmallMoleculeDrug DB00273 Topiramate Thumb 53.2%
2 Approved SmallMoleculeDrug DB01595 Nitrazepam Thumb 52.2%
3 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb 47.8%
4 Approved;
Vet approved		 SmallMoleculeDrug DB00252 Phenytoin Thumb 45.7%
5 Approved;
Investigational		 SmallMoleculeDrug DB00334 Olanzapine Thumb 44.2%
6 Approved SmallMoleculeDrug DB06218 Lacosamide Thumb 43.8%
7 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb 43.7%
8 Approved SmallMoleculeDrug DB00292 Etomidate Thumb 42.5%
9 Approved SmallMoleculeDrug DB01594 Cinolazepam Thumb 41.6%
10 Approved SmallMoleculeDrug DB00898 Ethanol Thumb 40.1%
11 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB01558 Bromazepam Thumb 40.1%
12 Approved;
Vet approved		 SmallMoleculeDrug DB00281 Lidocaine Thumb 39.2%
13 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb 38.4%
14 Approved;
Illicit		 SmallMoleculeDrug DB00683 Midazolam Thumb 37.8%
15 Approved;
Illicit		 SmallMoleculeDrug DB01588 Prazepam Thumb 37.4%
16 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 37.4%
17 Approved SmallMoleculeDrug DB00842 Oxazepam Thumb 37.2%
18 Approved;
Illicit		 SmallMoleculeDrug DB01559 Clotiazepam Thumb 37.0%
19 Approved SmallMoleculeDrug DB00186 Lorazepam Thumb 37.0%
20 Approved;
Illicit;
Investigational;
Vet approved		 SmallMoleculeDrug DB00829 Diazepam Thumb 36.8%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.