QuartataWeb
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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P51843
No. Gene UniProt ID Protein Name Pathway PDB
1 NR0B1 P51843 Nuclear receptor subfamily 0 group B member 1 hsa04927 4RWV


2 known interactions (drugs) of input target (NR0B1): Nuclear receptor subfamily 0 group B member 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01234 Dexamethasone Thumb
2 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb


20 predicted interactions (drugs) of input target (NR0B1): Nuclear receptor subfamily 0 group B member 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 SmallMoleculeDrug DB00523 Alitretinoin Thumb 23.8%
2 Approved;
Vet approved		 SmallMoleculeDrug DB00741 Hydrocortisone Thumb 23.5%
3 Approved SmallMoleculeDrug DB00210 Adapalene Thumb 20.4%
4 Approved SmallMoleculeDrug DB00288 Amcinonide Thumb 19.2%
5 Approved BiotechDrug DB00071 Insulin Pork Thumb 17.4%
6 Investigational SmallMoleculeDrug DB05785 LGD-1550 Thumb 17.3%
7 Approved SmallMoleculeDrug DB00421 Spironolactone Thumb 16.6%
8 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00254 Doxycycline Thumb 16.4%
9 Approved SmallMoleculeDrug DB00459 Acitretin Thumb 15.8%
10 Approved SmallMoleculeDrug DB01592 Iron Thumb 14.7%
11 Experimental SmallMoleculeDrug DB08371 PARA-(BENZOYL)-PHENYLALANINE Thumb 14.1%
12 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb 14.0%
13 Approved;
Investigational		 SmallMoleculeDrug DB00799 Tazarotene Thumb 13.9%
14 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00162 Vitamin A Thumb 13.9%
15 Approved;
Experimental;
Investigational		 SmallMoleculeDrug DB02709 Resveratrol Thumb 13.7%
16 Experimental SmallMoleculeDrug DB02740 3-Indolebutyric Acid Thumb 13.4%
17 Approved;
Investigational		 SmallMoleculeDrug DB08604 Triclosan Thumb 12.8%
18 Approved SmallMoleculeDrug DB00570 Vinblastine Thumb 12.8%
19 Experimental SmallMoleculeDrug DB01717 Bis(Adenosine)-5'-Pentaphosphate Thumb 12.8%
20 Experimental SmallMoleculeDrug DB01800 N,4-Dihydroxy-N-Oxo-3-(Sulfooxy)Benzenaminium Thumb 12.6%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.