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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.


10 known interactions (drugs) of input target (PRKCA): Protein kinase C alpha type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb
2 Investigational SmallMoleculeDrug DB06451 Aprinocarsen Thumb
3 Approved;
Nutraceutical;
Vet approved
SmallMoleculeDrug DB14002 D-alpha-Tocopherol acetate Thumb
4 Approved SmallMoleculeDrug DB05013 Ingenol Mebutate Thumb
5 Approved;
Investigational
SmallMoleculeDrug DB06595 Midostaurin Thumb
6 Investigational SmallMoleculeDrug DB06641 Perifosine Thumb
7 Approved;
Nutraceutical;
Vet approved
SmallMoleculeDrug DB00163 Vitamin E Thumb
8 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb
9 Approved;
Investigational;
Nutraceutical
SmallMoleculeDrug DB00144 Phosphatidyl serine Thumb
10 Approved;
Nutraceutical;
Vet approved
SmallMoleculeDrug DB14001 alpha-Tocopherol succinate Thumb


20 predicted interactions (drugs) of input target (PRKCA): Protein kinase C alpha type
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Experimental SmallMoleculeDrug DB01738 Phosphorylcolamine Thumb 33.1%
2 Approved;
Investigational;
Vet approved
SmallMoleculeDrug DB01110 Miconazole Thumb 24.9%
3 Approved;
Investigational
SmallMoleculeDrug DB08862 Cholecystokinin Thumb 24.8%
4 Approved;
Investigational
SmallMoleculeDrug DB01268 Sunitinib Thumb 21.5%
5 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 21.1%
6 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 20.9%
7 Approved;
Investigational
SmallMoleculeDrug DB00909 Zonisamide Thumb 20.8%
8 Approved;
Vet approved
SmallMoleculeDrug DB00819 Acetazolamide Thumb 20.0%
9 Approved;
Investigational
BiotechDrug DB01279 Galsulfase Thumb 20.0%
10 Experimental SmallMoleculeDrug DB03413 Deoxyuridine-5'-Diphosphate Thumb 19.9%
11 Approved;
Investigational;
Withdrawn
SmallMoleculeDrug DB00914 Phenformin Thumb 19.8%
12 Investigational SmallMoleculeDrug DB05146 XL820 Thumb 19.3%
13 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb 18.3%
14 Approved;
Experimental
SmallMoleculeDrug DB03796 Palmitic Acid Thumb 18.0%
15 Approved SmallMoleculeDrug DB01003 Cromoglicic acid Thumb 17.9%
16 Approved;
Nutraceutical
SmallMoleculeDrug DB00129 Ornithine Thumb 17.8%
17 Experimental SmallMoleculeDrug DB03435 Uridine-5'-Diphosphate Thumb 17.7%
18 Approved SmallMoleculeDrug DB00468 Quinine Thumb 17.7%
19 Approved SmallMoleculeDrug DB11605 Myrrh Thumb 17.7%
20 Approved;
Experimental;
Investigational
SmallMoleculeDrug DB01942 Formic Acid Thumb 17.7%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.