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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P07998
No. Gene UniProt ID Protein Name Pathway PDB
1 RNASE1 P07998 Ribonuclease pancreatic NA 1DZA; 1E21; 1H8X; 1Z7X; 2E0J; 2E0L; 2E0M; 2E0O; 2K11; 2Q4G; 3F8G; 4KXH

28 known interactions (drugs) of input target (RNASE1): Ribonuclease pancreatic
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental SmallMoleculeDrug DB03155 1-(2-Deoxy-2-Fluoro-3-O-Phosphono-Beta-L-Ribofuranosyl)Pyrimidine-2,4(1h,3h)-Dione Thumb
2 Experimental SmallMoleculeDrug DB01842 3'-Phosphate-Adenosine-5'-Diphosphate Thumb
3 Experimental SmallMoleculeDrug DB08661 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione Thumb
4 Experimental SmallMoleculeDrug DB02714 3'-Uridinemonophosphate Thumb
5 Experimental SmallMoleculeDrug DB04464 N-Formylmethionine Thumb
6 Experimental SmallMoleculeDrug DB03726 Purine Riboside-5'-Monophosphate Thumb
7 Experimental SmallMoleculeDrug DB03512 Uridine-2',3'-Vanadate Thumb
8 Approved;
SmallMoleculeDrug DB01942 Formic Acid Thumb
9 Experimental SmallMoleculeDrug DB03186 U-Pi-a-Pi Thumb
10 Experimental SmallMoleculeDrug DB03326 deoxycytidylyl-3',5'-guanosine Thumb
11 Experimental SmallMoleculeDrug DB02363 2'-Monophosphoadenosine-5'-Diphosphate Thumb
12 Experimental SmallMoleculeDrug DB03448 2'-Deoxyuridine 3'-Monophosphate Thumb
13 Approved;
Vet approved
SmallMoleculeDrug DB04272 Citric Acid Thumb
14 Experimental SmallMoleculeDrug DB02098 Adenosine-2'-5'-Diphosphate Thumb
15 Experimental SmallMoleculeDrug DB04514 Phosphoric Acid-2'-[2'-Deoxy-Uridine]Ester-5'-Guanosine Ester Thumb
16 Experimental SmallMoleculeDrug DB01812 Adenosine-3'-5'-Diphosphate Thumb
17 Experimental SmallMoleculeDrug DB03900 2-Methyl-2-Propanol Thumb
18 Experimental SmallMoleculeDrug DB02573 2'-Deoxycytidine-2'-Deoxyadenosine-3',5'-Monophosphate Thumb
19 Experimental SmallMoleculeDrug DB08596 5'-deoxy-5'-piperidin-1-ylthymidine Thumb
20 Experimental SmallMoleculeDrug DB03447 Uridylyl-2'-5'-Phospho-Adenosine Thumb
21 Experimental SmallMoleculeDrug DB02987 Cysteine-S-Acetamide Thumb
22 Experimental SmallMoleculeDrug DB01961 Cytidine 3'-monophosphate Thumb
23 Approved SmallMoleculeDrug DB00536 Guanidine Thumb
24 Approved;
SmallMoleculeDrug DB00128 L-Aspartic Acid Thumb
25 Experimental SmallMoleculeDrug DB03765 2'-cytidylic acid Thumb
26 Experimental SmallMoleculeDrug DB03792 5-Amino-1h-Pyrimidine-2,4-Dione Thumb
27 Approved;
SmallMoleculeDrug DB02325 Isopropyl Alcohol Thumb
28 Experimental SmallMoleculeDrug DB02805 Uracil arabinose-3'-phosphate Thumb

20 predicted interactions (drugs) of input target (RNASE1): Ribonuclease pancreatic
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB09130 Copper Thumb 43.0%
2 Approved SmallMoleculeDrug DB02659 Cholic Acid Thumb 30.5%
3 Experimental SmallMoleculeDrug DB04447 1,4-Dithiothreitol Thumb 29.8%
4 Experimental;
SmallMoleculeDrug DB02745 Uridine Thumb 28.7%
5 Experimental SmallMoleculeDrug DB04493 Fructose-6-Phosphate Thumb 28.5%
6 Experimental SmallMoleculeDrug DB03435 Uridine-5'-Diphosphate Thumb 25.7%
7 Approved;
SmallMoleculeDrug DB02709 Resveratrol Thumb 25.6%
8 Approved;
SmallMoleculeDrug DB01593 Zinc Thumb 25.5%
9 Experimental SmallMoleculeDrug DB03459 Sparfosic acid Thumb 25.2%
10 Approved;
BiotechDrug DB00013 Urokinase Thumb 25.0%
11 Experimental SmallMoleculeDrug DB01972 Guanosine-5'-Monophosphate Thumb 24.9%
12 Approved;
SmallMoleculeDrug DB11638 Artenimol Thumb 24.8%
13 Approved;
SmallMoleculeDrug DB03017 Lauric Acid Thumb 24.4%
14 Investigational BiotechDrug DB06245 Lanoteplase Thumb 24.4%
15 Experimental SmallMoleculeDrug DB07841 Geranylgeranyl diphosphate Thumb 24.1%
16 Approved;
SmallMoleculeDrug DB01373 Calcium Thumb 23.9%
17 Approved;
SmallMoleculeDrug DB03088 Pidolic Acid Thumb 23.7%
18 Approved;
SmallMoleculeDrug DB00290 Bleomycin Thumb 23.2%
19 Experimental SmallMoleculeDrug DB02783 4'-Deoxy-4'-Acetylyamino-Pyridoxal-5'-Phosphate Thumb 23.0%
20 Experimental SmallMoleculeDrug DB02548 D-glucitol 6-phosphate Thumb 23.0%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.