QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: Q92806
No. Gene UniProt ID Protein Name Pathway PDB
1 KCNJ9 Q92806 G protein-activated inward rectifier potassium channel 3 hsa04713; hsa04723; hsa04726; hsa04728; hsa04915; hsa04921; hsa05032 NA


2 known interactions (drugs) of input target (KCNJ9): G protein-activated inward rectifier potassium channel 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB11633 Isavuconazole Thumb
2 Approved SmallMoleculeDrug DB00898 Ethanol Thumb


20 predicted interactions (drugs) of input target (KCNJ9): G protein-activated inward rectifier potassium channel 3
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Vet approved		 SmallMoleculeDrug DB01159 Halothane Thumb 28.0%
2 Approved SmallMoleculeDrug DB00661 Verapamil Thumb 26.9%
3 Approved SmallMoleculeDrug DB09089 Trimebutine Thumb 23.3%
4 Approved;
Investigational		 SmallMoleculeDrug DB06712 Nilvadipine Thumb 23.3%
5 Approved;
Investigational		 SmallMoleculeDrug DB06217 Vernakalant Thumb 22.8%
6 Approved;
Investigational		 SmallMoleculeDrug DB00270 Isradipine Thumb 21.5%
7 Investigational SmallMoleculeDrug DB04982 Talampanel Thumb 21.4%
8 Approved SmallMoleculeDrug DB01115 Nifedipine Thumb 20.4%
9 Approved;
Vet approved		 SmallMoleculeDrug DB00753 Isoflurane Thumb 20.3%
10 Approved;
Investigational		 SmallMoleculeDrug DB01054 Nitrendipine Thumb 20.3%
11 Approved;
Experimental		 SmallMoleculeDrug DB13746 Bioallethrin Thumb 19.8%
12 Approved;
Withdrawn		 SmallMoleculeDrug DB01244 Bepridil Thumb 19.6%
13 Approved SmallMoleculeDrug DB01346 Quinidine barbiturate Thumb 19.4%
14 Approved;
Investigational		 SmallMoleculeDrug DB09229 Aranidipine Thumb 19.0%
15 Approved;
Investigational		 SmallMoleculeDrug DB00996 Gabapentin Thumb 18.5%
16 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00653 Magnesium sulfate Thumb 18.4%
17 Approved;
Investigational		 SmallMoleculeDrug DB00402 Eszopiclone Thumb 18.4%
18 Approved SmallMoleculeDrug DB00308 Ibutilide Thumb 18.3%
19 Approved;
Illicit		 SmallMoleculeDrug DB00241 Butalbital Thumb 18.2%
20 Approved SmallMoleculeDrug DB00674 Galantamine Thumb 17.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.