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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P50440
No. Gene UniProt ID Protein Name Pathway PDB
1 GATM P50440 Glycine amidinotransferase, mitochondrial hsa00260; hsa00330; hsa01100 1JDW; 1JDX; 2JDW; 2JDX; 3JDW; 4JDW; 5JDW; 6JDW; 7JDW; 8JDW; 9JDW


6 known interactions (drugs) of input target (GATM): Glycine amidinotransferase, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB02530 gamma-Aminobutyric acid Thumb
2 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB00145 Glycine Thumb
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB00129 Ornithine Thumb
4 Experimental SmallMoleculeDrug DB04454 Alpha-Aminobutyric Acid Thumb
5 Experimental SmallMoleculeDrug DB04185 Norvaline Thumb
6 Experimental SmallMoleculeDrug DB02068 Delta-Amino Valeric Acid Thumb


20 predicted interactions (drugs) of input target (GATM): Glycine amidinotransferase, mitochondrial
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00125 L-Arginine Thumb 34.0%
2 Experimental SmallMoleculeDrug DB00466 Picrotoxin Thumb 33.2%
3 Approved;
Nutraceutical		 SmallMoleculeDrug DB00123 L-Lysine Thumb 29.2%
4 Approved;
Withdrawn		 SmallMoleculeDrug DB00431 Lindane Thumb 27.7%
5 Approved;
Investigational		 SmallMoleculeDrug DB01593 Zinc Thumb 26.7%
6 Approved;
Nutraceutical		 SmallMoleculeDrug DB01956 Taurine Thumb 24.3%
7 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00755 Tretinoin Thumb 24.1%
8 Experimental SmallMoleculeDrug DB01717 Bis(Adenosine)-5'-Pentaphosphate Thumb 23.3%
9 Approved SmallMoleculeDrug DB00768 Olopatadine Thumb 23.0%
10 Experimental SmallMoleculeDrug DB02854 Aetiocholanolone Thumb 22.2%
11 Investigational SmallMoleculeDrug DB05036 Grn163l Thumb 22.0%
12 Investigational SmallMoleculeDrug DB08846 Ellagic Acid Thumb 21.7%
13 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb 21.6%
14 Experimental SmallMoleculeDrug DB03731 S-2-(Boronoethyl)-L-Cysteine Thumb 21.0%
15 Approved SmallMoleculeDrug DB02659 Cholic Acid Thumb 20.0%
16 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00155 L-Citrulline Thumb 19.5%
17 Approved;
Nutraceutical;
Vet approved		 SmallMoleculeDrug DB14002 D-alpha-Tocopherol acetate Thumb 18.8%
18 Experimental SmallMoleculeDrug DB02260 4-Oxosebacic Acid Thumb 18.7%
19 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00602 Ivermectin Thumb 18.6%
20 Experimental SmallMoleculeDrug DB02878 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid Thumb 17.7%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.