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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P31645
No. Gene UniProt ID Protein Name Pathway PDB
1 SLC6A4 P31645 Sodium-dependent serotonin transporter hsa04726 NA


65 known interactions (drugs) of input target (SLC6A4): Sodium-dependent serotonin transporter
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB00422 Methylphenidate Thumb
2 Approved SmallMoleculeDrug DB00514 Dextromethorphan Thumb
3 Withdrawn SmallMoleculeDrug DB04832 Zimelidine Thumb
4 Approved SmallMoleculeDrug DB00321 Amitriptyline Thumb
5 Approved;
Illicit		 SmallMoleculeDrug DB00191 Phentermine Thumb
6 Approved;
Investigational		 SmallMoleculeDrug DB06701 Dexmethylphenidate Thumb
7 Approved SmallMoleculeDrug DB00408 Loxapine Thumb
8 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB00574 Fenfluramine Thumb
9 Approved SmallMoleculeDrug DB00476 Duloxetine Thumb
10 Approved;
Investigational		 SmallMoleculeDrug DB00656 Trazodone Thumb
11 Approved;
Investigational		 SmallMoleculeDrug DB01175 Escitalopram Thumb
12 Approved;
Withdrawn		 SmallMoleculeDrug DB01149 Nefazodone Thumb
13 Illicit;
Withdrawn		 SmallMoleculeDrug DB04836 Amineptine Thumb
14 Approved SmallMoleculeDrug DB00661 Verapamil Thumb
15 Experimental SmallMoleculeDrug DB09186 Nisoxetine Thumb
16 Approved SmallMoleculeDrug DB00458 Imipramine Thumb
17 Approved SmallMoleculeDrug DB00454 Pethidine Thumb
18 Approved SmallMoleculeDrug DB00988 Dopamine Thumb
19 Investigational SmallMoleculeDrug DB06156 Tesofensine Thumb
20 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB01242 Clomipramine Thumb
21 Approved SmallMoleculeDrug DB00805 Minaprine Thumb
22 Approved SmallMoleculeDrug DB00289 Atomoxetine Thumb
23 Investigational SmallMoleculeDrug DB05422 OPC-14523 Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB06148 Mianserin Thumb
25 Approved SmallMoleculeDrug DB09016 Butriptyline Thumb
26 Approved;
Investigational		 SmallMoleculeDrug DB09068 Vortioxetine Thumb
27 Approved;
Vet approved		 SmallMoleculeDrug DB00472 Fluoxetine Thumb
28 Approved SmallMoleculeDrug DB00852 Pseudoephedrine Thumb
29 Approved;
Illicit		 SmallMoleculeDrug DB00907 Cocaine Thumb
30 Approved SmallMoleculeDrug DB01114 Chlorphenamine Thumb
31 Approved SmallMoleculeDrug DB00215 Citalopram Thumb
32 Approved;
Investigational;
Withdrawn		 SmallMoleculeDrug DB09225 Zotepine Thumb
33 Investigational SmallMoleculeDrug DB05964 Amitifadine Thumb
34 Approved;
Investigational		 SmallMoleculeDrug DB00579 Mazindol Thumb
35 Approved SmallMoleculeDrug DB00344 Protriptyline Thumb
36 Approved;
Investigational		 SmallMoleculeDrug DB00193 Tramadol Thumb
37 Investigational;
Nutraceutical		 SmallMoleculeDrug DB08839 Serotonin Thumb
38 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01105 Sibutramine Thumb
39 Approved SmallMoleculeDrug DB09195 Lorpiprazole Thumb
40 Approved SmallMoleculeDrug DB00285 Venlafaxine Thumb
41 Withdrawn SmallMoleculeDrug DB04821 Nomifensine Thumb
42 Approved;
Investigational		 SmallMoleculeDrug DB00176 Fluvoxamine Thumb
43 Investigational SmallMoleculeDrug DB04889 Bicifadine Thumb
44 Approved;
Investigational		 SmallMoleculeDrug DB04896 Milnacipran Thumb
45 Approved SmallMoleculeDrug DB00726 Trimipramine Thumb
46 Experimental;
Illicit		 SmallMoleculeDrug DB01442 MMDA Thumb
47 Approved SmallMoleculeDrug DB09167 Dosulepin Thumb
48 Approved;
Investigational		 SmallMoleculeDrug DB00715 Paroxetine Thumb
49 Approved SmallMoleculeDrug DB00543 Amoxapine Thumb
50 Experimental;
Illicit		 SmallMoleculeDrug DB01472 4-Methoxyamphetamine Thumb
51 Experimental;
Illicit;
Investigational		 SmallMoleculeDrug DB01454 Midomafetamine Thumb
52 Approved SmallMoleculeDrug DB00370 Mirtazapine Thumb
53 Approved;
Investigational		 SmallMoleculeDrug DB08918 Levomilnacipran Thumb
54 Approved;
Investigational		 SmallMoleculeDrug DB01142 Doxepin Thumb
55 Approved SmallMoleculeDrug DB01104 Sertraline Thumb
56 Approved;
Illicit;
Investigational		 SmallMoleculeDrug DB00182 Amphetamine Thumb
57 Approved;
Nutraceutical;
Withdrawn		 SmallMoleculeDrug DB01363 Ephedra Thumb
58 Approved;
Illicit		 SmallMoleculeDrug DB01577 Methamphetamine Thumb
59 Approved SmallMoleculeDrug DB06204 Tapentadol Thumb
60 Approved;
Investigational		 SmallMoleculeDrug DB01151 Desipramine Thumb
61 Approved;
Illicit;
Investigational;
Withdrawn		 SmallMoleculeDrug DB01191 Dexfenfluramine Thumb
62 Approved;
Investigational		 SmallMoleculeDrug DB06700 Desvenlafaxine Thumb
63 Investigational SmallMoleculeDrug DB12305 Dasotraline Thumb
64 Approved SmallMoleculeDrug DB00540 Nortriptyline Thumb
65 Investigational SmallMoleculeDrug DB05688 CRx-119 Thumb


20 predicted interactions (drugs) of input target (SLC6A4): Sodium-dependent serotonin transporter
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Vet approved		 SmallMoleculeDrug DB01221 Ketamine Thumb 86.1%
2 Approved;
Investigational		 SmallMoleculeDrug DB00934 Maprotiline Thumb 80.5%
3 Approved;
Illicit		 SmallMoleculeDrug DB01576 Dextroamphetamine Thumb 79.7%
4 Approved;
Investigational		 SmallMoleculeDrug DB00555 Lamotrigine Thumb 77.6%
5 Approved;
Illicit		 SmallMoleculeDrug DB01579 Phendimetrazine Thumb 76.4%
6 Investigational BiotechDrug DB06333 Trodusquemine Thumb 72.9%
7 Approved SmallMoleculeDrug DB00696 Ergotamine Thumb 72.8%
8 Approved SmallMoleculeDrug DB01364 Ephedrine Thumb 72.7%
9 Approved;
Illicit		 SmallMoleculeDrug DB00865 Benzphetamine Thumb 72.7%
10 Approved SmallMoleculeDrug DB01173 Orphenadrine Thumb 72.5%
11 Approved;
Investigational		 SmallMoleculeDrug DB01238 Aripiprazole Thumb 72.3%
12 Approved SmallMoleculeDrug DB01156 Bupropion Thumb 71.4%
13 Approved;
Investigational		 SmallMoleculeDrug DB01624 Zuclopenthixol Thumb 71.4%
14 Approved SmallMoleculeDrug DB00449 Dipivefrin Thumb 71.3%
15 Approved SmallMoleculeDrug DB01224 Quetiapine Thumb 71.0%
16 Approved;
Investigational		 SmallMoleculeDrug DB14185 Aripiprazole lauroxil Thumb 70.8%
17 Approved SmallMoleculeDrug DB00502 Haloperidol Thumb 70.5%
18 Approved;
Investigational;
Vet approved		 SmallMoleculeDrug DB00477 Chlorpromazine Thumb 69.3%
19 Approved SmallMoleculeDrug DB00245 Benzatropine Thumb 69.2%
20 Approved SmallMoleculeDrug DB00246 Ziprasidone Thumb 69.2%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.