QuartataWeb
Home  |   About  |   Theory  |   Tutorials  |   FAQ  |   Bahar Lab  |   Statistics
 

Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.


29 known interactions (drugs) of input target (EGFR): Epidermal growth factor receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB05294 Vandetanib Thumb
2 Approved;
Investigational		 SmallMoleculeDrug DB00317 Gefitinib Thumb
3 Approved BiotechDrug DB10772 Foreskin keratinocyte (neonatal) Thumb
4 Approved BiotechDrug DB00002 Cetuximab Thumb
5 Investigational BiotechDrug DB12202 Zalutumumab Thumb
6 Approved SmallMoleculeDrug DB08916 Afatinib Thumb
7 Investigational SmallMoleculeDrug DB05944 Varlitinib Thumb
8 Approved;
Investigational		 SmallMoleculeDrug DB01259 Lapatinib Thumb
9 Investigational BiotechDrug DB04988 IGN311 Thumb
10 Experimental SmallMoleculeDrug DB07662 N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE Thumb
11 Approved;
Investigational		 BiotechDrug DB09559 Necitumumab Thumb
12 Approved;
Investigational		 SmallMoleculeDrug DB11737 Icotinib Thumb
13 Investigational BiotechDrug DB05101 Matuzumab Thumb
14 Approved;
Investigational		 BiotechDrug DB01269 Panitumumab Thumb
15 Approved;
Investigational		 SmallMoleculeDrug DB12010 Fostamatinib Thumb
16 Investigational SmallMoleculeDrug DB11731 Depatuxizumab mafodotin Thumb
17 Investigational SmallMoleculeDrug DB05424 Canertinib Thumb
18 Approved;
Investigational		 SmallMoleculeDrug DB00530 Erlotinib Thumb
19 Experimental;
Investigational		 SmallMoleculeDrug DB03496 Alvocidib Thumb
20 Approved;
Investigational		 BiotechDrug DB00072 Trastuzumab Thumb
21 Approved;
Vet approved		 SmallMoleculeDrug DB00281 Lidocaine Thumb
22 Approved SmallMoleculeDrug DB09330 Osimertinib Thumb
23 Investigational SmallMoleculeDrug DB06021 AV-412 Thumb
24 Approved;
Investigational		 SmallMoleculeDrug DB13164 Olmutinib Thumb
25 Investigational SmallMoleculeDrug DB05524 Pelitinib Thumb
26 Investigational SmallMoleculeDrug DB05374 Rindopepimut Thumb
27 Approved;
Investigational		 SmallMoleculeDrug DB11828 Neratinib Thumb
28 Experimental SmallMoleculeDrug DB07602 S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE Thumb
29 Approved;
Investigational		 SmallMoleculeDrug DB12267 Brigatinib Thumb


20 predicted interactions (drugs) of input target (EGFR): Epidermal growth factor receptor
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image Confidence score
1 Approved;
Investigational		 BiotechDrug DB05773 Trastuzumab emtansine Thumb 45.2%
2 Approved;
Investigational		 BiotechDrug DB13998 Lonoctocog alfa Thumb 41.1%
3 Approved;
Investigational		 SmallMoleculeDrug DB09130 Copper Thumb 40.2%
4 Approved;
Investigational		 SmallMoleculeDrug DB01017 Minocycline Thumb 38.7%
5 Approved;
Investigational		 BiotechDrug DB06372 Rilonacept Thumb 38.6%
6 Investigational SmallMoleculeDrug DB11652 Tucatinib Thumb 37.7%
7 Approved;
Investigational		 SmallMoleculeDrug DB11638 Artenimol Thumb 37.2%
8 Approved SmallMoleculeDrug DB08896 Regorafenib Thumb 37.0%
9 Approved;
Investigational		 BiotechDrug DB00025 Antihemophilic factor, human recombinant Thumb 35.4%
10 Approved;
Investigational		 SmallMoleculeDrug DB05676 Apremilast Thumb 34.8%
11 Investigational SmallMoleculeDrug DB05767 Andrographolide Thumb 33.9%
12 Approved;
Investigational		 SmallMoleculeDrug DB01254 Dasatinib Thumb 33.8%
13 Approved;
Vet approved		 SmallMoleculeDrug DB00945 Acetylsalicylic acid Thumb 33.8%
14 Approved BiotechDrug DB06366 Pertuzumab Thumb 32.6%
15 Approved SmallMoleculeDrug DB03147 Flavin adenine dinucleotide Thumb 30.9%
16 Investigational SmallMoleculeDrug DB05412 Talmapimod Thumb 30.3%
17 Approved;
Investigational		 BiotechDrug DB00042 Botulinum Toxin Type B Thumb 30.1%
18 Approved BiotechDrug DB13999 Moroctocog alfa Thumb 30.0%
19 Investigational SmallMoleculeDrug DB05004 AC162352 Thumb 29.8%
20 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00131 Adenosine monophosphate Thumb 29.5%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.