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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: target; # of requested predictions: 20; Secondary interactions: no
Input target 1: P16152
No. Gene UniProt ID Protein Name Pathway PDB
1 CBR1 P16152 Carbonyl reductase [NADPH] 1 hsa00590; hsa00790; hsa00980; hsa01100; hsa05204 1WMA; 2PFG; 3BHI; 3BHJ; 3BHM; 4Z3D

6 known interactions (drugs) of input target (CBR1): Carbonyl reductase [NADPH] 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Experimental;
SmallMoleculeDrug DB01698 Rutin Thumb
2 Experimental SmallMoleculeDrug DB04463 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Thumb
3 Experimental;
SmallMoleculeDrug DB04216 Quercetin Thumb
4 Approved;
SmallMoleculeDrug DB02709 Resveratrol Thumb
5 Experimental SmallMoleculeDrug DB03556 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Thumb
6 Approved;
SmallMoleculeDrug DB11672 Curcumin Thumb

20 predicted interactions (drugs) of input target (CBR1): Carbonyl reductase [NADPH] 1
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image Confidence score
1 Approved;
SmallMoleculeDrug DB12010 Fostamatinib Thumb 33.3%
2 Approved;
SmallMoleculeDrug DB09462 Glycerin Thumb 25.4%
3 Investigational SmallMoleculeDrug DB06486 Enzastaurin Thumb 23.8%
4 Approved SmallMoleculeDrug DB01039 Fenofibrate Thumb 23.2%
5 Investigational SmallMoleculeDrug DB06089 ICA-105665 Thumb 20.9%
6 Approved;
SmallMoleculeDrug DB00909 Zonisamide Thumb 20.7%
7 Approved SmallMoleculeDrug DB00244 Mesalazine Thumb 20.4%
8 Approved SmallMoleculeDrug DB13873 Fenofibric acid Thumb 19.9%
9 Approved;
SmallMoleculeDrug DB00412 Rosiglitazone Thumb 19.9%
10 Approved;
SmallMoleculeDrug DB01708 Prasterone Thumb 19.8%
11 Approved;
SmallMoleculeDrug DB00313 Valproic Acid Thumb 19.6%
12 Experimental SmallMoleculeDrug DB08231 Myristic acid Thumb 19.6%
13 Experimental SmallMoleculeDrug DB08744 6-methoxy-9-methyl[1,3]dioxolo[4,5-h]quinolin-8(9H)-one Thumb 18.6%
14 Experimental SmallMoleculeDrug DB01863 Inositol 1,3,4,5-Tetrakisphosphate Thumb 18.5%
15 Approved;
SmallMoleculeDrug DB09071 Tasimelteon Thumb 18.4%
16 Experimental SmallMoleculeDrug DB07053 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID Thumb 18.3%
17 Approved SmallMoleculeDrug DB01087 Primaquine Thumb 18.3%
18 Investigational SmallMoleculeDrug DB04468 Afimoxifene Thumb 18.2%
19 Investigational SmallMoleculeDrug DB12695 Phenethyl Isothiocyanate Thumb 17.7%
20 Experimental SmallMoleculeDrug DB03600 Capric acid Thumb 17.6%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.