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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB04892
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Investigational SmallMoleculeDrug DB04892 Phenserine Thumb


3 known interactions (targets) of input drug (DB04892): Phenserine
No. Gene UniProt ID Protein Name Pathway PDB
1 ACHE P22303 Acetylcholinesterase hsa00564; hsa04725 1B41; 1F8U; 1PUV; 1PUW; 1VZJ; 2CLJ; 2X8B; 3LII; 4BDT; 4EY4; 4EY5; 4EY6; 4EY7; 4EY8; 4M0E; 4M0F; 4PQE
2 BCHE P06276 Cholinesterase NA
3 APP P05067 Amyloid beta A4 protein hsa04726; hsa05010


20 predicted interactions (targets) of input drug (DB04892): Phenserine
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 PCYT1A P49585 Choline-phosphate cytidylyltransferase A hsa00440; hsa00564; hsa01100; hsa05231 NA 22.9%
2 CHRNA7 P36544 Neuronal acetylcholine receptor subunit alpha-7 NA 2MAW; 5AFH; 5AFJ; 5AFK; 5AFL; 5AFM; 5AFN 22.5%
3 NR3C2 P08235 Mineralocorticoid receptor hsa04960 1Y9R; 1YA3; 2A3I; 2AA2; 2AA5; 2AA6; 2AA7; 2AAX; 2AB2; 2ABI; 2OAX; 3VHU; 3VHV; 3WFF; 3WFG; 4PF3; 4TNT 18.7%
4 TF P02787 Serotransferrin hsa04066; hsa04216; hsa04978 18.7%
5 PLD1 Q13393 Phospholipase D1 hsa00564; hsa00565; hsa01100; hsa04014; hsa04024; hsa04071; hsa04072; hsa04144; hsa04666; hsa04724; hsa04912; hsa04928; hsa05200; hsa05212; hsa05231 NA 17.6%
6 PCYT1B Q9Y5K3 Choline-phosphate cytidylyltransferase B hsa00440; hsa00564; hsa01100; hsa05231 NA 17.2%
7 ANXA5 P08758 Annexin A5 NA 1ANW; 1ANX; 1AVH; 1AVR; 1HAK; 1HVD; 1HVE; 1HVF; 1HVG; 1SAV; 2XO2; 2XO3 16.9%
8 PLD2 O14939 Phospholipase D2 hsa00564; hsa00565; hsa01100; hsa04014; hsa04024; hsa04071; hsa04072; hsa04144; hsa04666; hsa04724; hsa04912; hsa04928; hsa05231 NA 16.4%
9 AR P10275 Androgen receptor hsa04114; hsa05200; hsa05215 16.1%
10 NR1I2 O75469 Nuclear receptor subfamily 1 group I member 2 NA 16.1%
11 CHRNA4 P43681 Neuronal acetylcholine receptor subunit alpha-4 hsa04080; hsa04725; hsa05033 2GVT; 2LLY 15.8%
12 CHRNA9 Q9UGM1 Neuronal acetylcholine receptor subunit alpha-9 hsa04080 4D01; 4UXU; 4UY2 15.7%
13 PHOSPHO1 Q8TCT1 Phosphoethanolamine/phosphocholine phosphatase hsa00564; hsa01100 NA 15.6%
14 GRIN3A Q8TCU5 Glutamate receptor ionotropic, NMDA 3A hsa04024; hsa04080; hsa04724; hsa05030; hsa05031; hsa05033; hsa05034 NA 15.5%
15 ADORA3 P0DMS8 Adenosine receptor A3 hsa04022; hsa04071; hsa04080 1OEA; 1R7N 15.0%
16 ALOX15 P16050 Arachidonate 15-lipoxygenase hsa00590; hsa00591; hsa01100; hsa04216; hsa04217; hsa04726 2ABT 14.8%
17 TYMS P04818 Thymidylate synthase hsa00240; hsa00670; hsa01100; hsa01523 14.7%
18 IL5 P05113 Interleukin-5 hsa04060; hsa04630; hsa04640; hsa04657; hsa04658; hsa04660; hsa04664; hsa04672; hsa05200; hsa05310; hsa05320; hsa05321; hsa05330 1HUL; 3QT2; 3VA2 14.1%
19 PLAT P00750 Tissue-type plasminogen activator hsa04371; hsa04610; hsa05202; hsa05215; hsa05418 1A5H; 1BDA; 1PK2; 1PML; 1RTF; 1TPG; 1TPK; 1TPM; 1TPN; 5BRR 13.5%
20 CYSLTR1 Q9Y271 Cysteinyl leukotriene receptor 1 hsa04020; hsa04080 NA 13.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.