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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB00675
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved SmallMoleculeDrug DB00675 Tamoxifen Thumb


16 known interactions (targets) of input drug (DB00675): Tamoxifen
No. Gene UniProt ID Protein Name Pathway PDB
1 PRKCZ Q05513 Protein kinase C zeta type hsa04015; hsa04062; hsa04071; hsa04144; hsa04360; hsa04390; hsa04530; hsa04611; hsa04910; hsa04926; hsa04930; hsa04931; hsa04933; hsa05165; hsa05418 NA
2 NR1I2 O75469 Nuclear receptor subfamily 1 group I member 2 NA
3 PRKCG P05129 Protein kinase C gamma type hsa01521; hsa04010; hsa04012; hsa04014; hsa04015; hsa04020; hsa04066; hsa04070; hsa04071; hsa04150; hsa04270; hsa04310; hsa04370; hsa04510; hsa04540; hsa04650; hsa04666; hsa04670; hsa04713; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04730; hsa04750; hsa04911; hsa04916; hsa04918; hsa04919; hsa04921; hsa04925; hsa04928; hsa04960; hsa04961; hsa04970; hsa04971; hsa04972; hsa05031; hsa05032; hsa05143; hsa05146; hsa05161; hsa05163; hsa05170; hsa05200; hsa05205; hsa05206; hsa05214; hsa05223; hsa05225; hsa05231 2E73; 2UZP
4 ESR1 P03372 Estrogen receptor hsa01522; hsa04915; hsa04917; hsa04919; hsa04961; hsa05200; hsa05205; hsa05224
5 PRKCA P17252 Protein kinase C alpha type hsa01521; hsa04010; hsa04012; hsa04014; hsa04015; hsa04020; hsa04066; hsa04070; hsa04071; hsa04072; hsa04150; hsa04151; hsa04261; hsa04270; hsa04310; hsa04360; hsa04370; hsa04510; hsa04540; hsa04650; hsa04664; hsa04666; hsa04670; hsa04713; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04730; hsa04750; hsa04911; hsa04912; hsa04916; hsa04918; hsa04919; hsa04921; hsa04925; hsa04926; hsa04928; hsa04933; hsa04960; hsa04961; hsa04970; hsa04971; hsa04972; hsa05031; hsa05032; hsa05110; hsa05130; hsa05143; hsa05146; hsa05161; hsa05163; hsa05164; hsa05170; hsa05200; hsa05205; hsa05206; hsa05214; hsa05223; hsa05225; hsa05231 2ELI; 3IW4; 4DNL; 4RA4
6 PRKCE Q02156 Protein kinase C epsilon type hsa04022; hsa04071; hsa04270; hsa04371; hsa04530; hsa04666; hsa04750; hsa04925; hsa04930; hsa04931; hsa04933; hsa05206 2WH0
7 AR P10275 Androgen receptor hsa04114; hsa05200; hsa05215
8 PRKCB P05771 Protein kinase C beta type hsa01521; hsa04010; hsa04012; hsa04014; hsa04015; hsa04020; hsa04062; hsa04064; hsa04066; hsa04070; hsa04071; hsa04150; hsa04270; hsa04310; hsa04370; hsa04510; hsa04540; hsa04650; hsa04662; hsa04666; hsa04670; hsa04713; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04730; hsa04750; hsa04911; hsa04912; hsa04916; hsa04918; hsa04919; hsa04921; hsa04925; hsa04928; hsa04931; hsa04933; hsa04960; hsa04961; hsa04970; hsa04971; hsa04972; hsa04973; hsa05031; hsa05032; hsa05140; hsa05143; hsa05146; hsa05161; hsa05163; hsa05164; hsa05170; hsa05200; hsa05205; hsa05206; hsa05214; hsa05223; hsa05225; hsa05231 2I0E
9 SHBG P04278 Sex hormone-binding globulin NA 1D2S; 1F5F; 1KDK; 1KDM; 1LHN; 1LHO; 1LHU; 1LHV; 1LHW
10 PRKCI P41743 Protein kinase C iota type hsa04015; hsa04144; hsa04390; hsa04530; hsa04611; hsa04910; hsa05165 1VD2; 1WMH; 1ZRZ; 3A8W; 3A8X; 3ZH8
11 ESRRG P62508 Estrogen-related receptor gamma NA 1KV6; 1TFC; 1VJB; 2E2R; 2EWP; 2GP7; 2GPO; 2GPP; 2GPU; 2GPV; 2P7A; 2P7G; 2P7Z; 2ZAS; 2ZBS; 2ZKC
12 PRKCD Q05655 Protein kinase C delta type hsa04062; hsa04140; hsa04270; hsa04621; hsa04625; hsa04666; hsa04722; hsa04750; hsa04912; hsa04915; hsa04930; hsa04931; hsa04933 1YRK; 2YUU
13 EBP Q15125 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase hsa00100; hsa01100 NA
14 PRKCQ Q04759 Protein kinase C theta type hsa04064; hsa04140; hsa04270; hsa04658; hsa04659; hsa04660; hsa04750; hsa04920; hsa04931; hsa05162 1XJD; 2ENJ; 2ENN; 2ENZ; 2JED; 4Q9Z; 4RA5
15 ESR2 Q92731 Estrogen receptor beta hsa01522; hsa04915; hsa04917; hsa05200; hsa05224
16 KCNH2 Q12809 Potassium voltage-gated channel subfamily H member 2 NA 1BYW; 1UJL; 2L0W; 2L1M; 2L4R; 2LE7; 4HP9; 4HQA


20 predicted interactions (targets) of input drug (DB00675): Tamoxifen
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 HRH1 P35367 Histamine H1 receptor hsa04020; hsa04080; hsa04750 3RZE 59.8%
2 NCOA2 Q15596 Nuclear receptor coactivator 2 hsa04915; hsa04919 55.6%
3 ALOX5 P09917 Arachidonate 5-lipoxygenase hsa00590; hsa01100; hsa04664; hsa04726; hsa04913; hsa05145 2ABV; 3O8Y; 3V92; 3V98; 3V99 40.6%
4 PGR P06401 Progesterone receptor hsa04114; hsa04914; hsa04915; hsa05224 1A28; 1E3K; 1SQN; 1SR7; 1ZUC; 2C7A; 2OVH; 2OVM; 2W8Y; 3D90; 3G8O; 3HQ5; 3KBA; 3ZR7; 3ZRA; 3ZRB; 4A2J; 4APU; 4OAR 40.2%
5 NCOA1 Q15788 Nuclear receptor coactivator 1 hsa04915; hsa04919; hsa05200; hsa05224 39.7%
6 DRD1 P21728 D(1A) dopamine receptor hsa04020; hsa04024; hsa04080; hsa04540; hsa04728; hsa05012; hsa05030; hsa05031; hsa05032; hsa05034 1OZ5 37.5%
7 DRD3 P35462 D(3) dopamine receptor hsa04080; hsa04728 3PBL 36.7%
8 PIM1 P11309 Serine/threonine-protein kinase pim-1 hsa04630; hsa04933; hsa05200; hsa05206; hsa05221 34.2%
9 ADRA2A P08913 Alpha-2A adrenergic receptor hsa04022; hsa04080 1HLL; 1HO9; 1HOD; 1HOF 34.1%
10 NR1I3 Q14994 Nuclear receptor subfamily 1 group I member 3 NA 1XV9; 1XVP 33.7%
11 MT-ATP6 P00846 ATP synthase subunit a hsa00190; hsa01100; hsa04714; hsa05010; hsa05012; hsa05016 NA 33.6%
12 DRD5 P21918 D(1B) dopamine receptor hsa04020; hsa04024; hsa04080; hsa04728 NA 33.0%
13 CHRM1 P11229 Muscarinic acetylcholine receptor M1 hsa04020; hsa04024; hsa04080; hsa04151; hsa04725; hsa04810 NA 32.2%
14 PDE5A O76074 cGMP-specific 3',5'-cyclic phosphodiesterase hsa00230; hsa04022 32.1%
15 HTR1A P08908 5-hydroxytryptamine receptor 1A hsa04024; hsa04080; hsa04726; hsa04742 NA 31.9%
16 GPER1 Q99527 G-protein coupled estrogen receptor 1 hsa01522; hsa04915 NA 31.6%
17 BECN1 Q14457 Beclin-1 hsa04136; hsa04137; hsa04140; hsa04215; hsa04371; hsa05167 2P1L; 2PON; 3DVU; 4DDP; 4MI8; 5EFM; 5HHE 31.6%
18 SLC6A3 Q01959 Sodium-dependent dopamine transporter hsa04728; hsa05012; hsa05030; hsa05031; hsa05034 NA 31.0%
19 ADRA1D P25100 Alpha-1D adrenergic receptor hsa04020; hsa04022; hsa04080; hsa04261; hsa04270; hsa04970 NA 30.8%
20 SLC6A4 P31645 Sodium-dependent serotonin transporter hsa04726 NA 30.6%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.