QuartataWeb 1.0

3 known interactions (targets) of input drug (DB08916): Afatinib

No.	Gene	UniProt ID	Protein Name	Pathway	PDB
1	EGFR	P00533	Epidermal growth factor receptor	hsa01521; hsa01522; hsa04010; hsa04012; hsa04014; hsa04015; hsa04020; hsa04066; hsa04068; hsa04072; hsa04144; hsa04151; hsa04510; hsa04520; hsa04540; hsa04630; hsa04810; hsa04912; hsa04915; hsa04921; hsa04926; hsa04928; hsa04934; hsa05120; hsa05160; hsa05163; hsa05165; hsa05200; hsa05205; hsa05206; hsa05210; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05219; hsa05223; hsa05224; hsa05225; hsa05226; hsa05230; hsa05231	4G5J; 1DNQ; 1DNR; 1IVO; 1M14; 1M17; 1MOX; 1NQL; 1XKK; 1YY9; 1Z9I; 2EB2; 2EB3; 2EXP; 2EXQ; 2GS2; 2GS6; 2GS7; 2ITN; 2ITO; 2ITP; 2ITQ; 2ITT; 2ITU; 2ITV; 2ITW; 2ITX; 2ITY; 2ITZ; 2J5E; 2J5F; 2J6M; 2JIT; 2JIU; 2JIV; 2KS1; 2M0B; 2M20; 2N5S; 2RF9; 2RFD; 2RFE; 2RGP; 3B2U; 3B2V; 3BEL; 3BUO; 3C09; 3G5V; 3G5Y; 3GOP; 3GT8; 3IKA; 3LZB; 3NJP; 3OB2; 3OP0; 3P0Y; 3PFV; 3POZ; 3QWQ; 3UG1; 3UG2; 3VJN; 3VJO; 3VRP; 3VRR; 3W2O; 3W2P; 3W2Q; 3W2R; 3W2S; 3W32; 3W33; 4G5J; 4G5P; 4HJO; 4I1Z; 4I20; 4I21; 4I22; 4I23; 4I24; 4JQ7; 4JQ8; 4JR3; 4JRV; 4KRL; 4KRM; 4KRO; 4KRP; 4LI5; 4LL0; 4LQM; 4LRM; 4R3P; 4R3R; 4R5S; 4RIW; 4RIX; 4RIY; 4RJ4; 4RJ5; 4RJ6; 4RJ7; 4RJ8; 4TKS; 4UV7; 4WKQ; 4WRG; 4ZAU; 4ZJV; 5C8K; 5C8M; 5C8N; 5CAL; 5CAN; 5CAO; 5CAP; 5CAQ; 5CAS; 5CAU; 5CAV; 5CNN; 5CNO; 5CZH; 5CZI
2	ERBB2	P04626	Receptor tyrosine-protein kinase erbB-2	hsa01521; hsa01522; hsa01524; hsa04010; hsa04012; hsa04020; hsa04066; hsa04151; hsa04510; hsa04520; hsa04530; hsa05200; hsa05205; hsa05206; hsa05212; hsa05213; hsa05215; hsa05219; hsa05223; hsa05224; hsa05226; hsa05230	4G5J; 1MFG; 1MFL; 1MW4; 1N8Z; 1OVC; 1QR1; 1S78; 2A91; 2JWA; 2KS1; 2L4K; 3BE1; 3H3B; 3MZW; 3N85; 3PP0; 3RCD; 3WLW; 3WSQ; 4GFU; 4HRL; 4HRM; 4HRN
3	ERBB4	Q15303	Receptor tyrosine-protein kinase erbB-4	hsa04010; hsa04012; hsa04020; hsa04151; hsa05205	4G5J; 2AHX; 2L2T; 2LCX; 2R4B; 3BBT; 3BBW; 3BCE; 3U2P; 3U7U; 3U9U

20 predicted interactions (targets) of input drug (DB08916): Afatinib

No.	Gene	UniProt ID	Protein Name	Pathway	PDB	Confidence score
1	MET	P08581	Hepatocyte growth factor receptor	hsa01521; hsa04010; hsa04014; hsa04015; hsa04151; hsa04360; hsa04510; hsa04520; hsa05100; hsa05120; hsa05144; hsa05200; hsa05202; hsa05205; hsa05206; hsa05211; hsa05218; hsa05225; hsa05226; hsa05230	1FYR; 1R0P; 1R1W; 1SHY; 1SSL; 1UX3; 2G15; 2RFN; 2RFS; 2UZX; 2UZY; 2WD1; 2WGJ; 2WKM; 3A4P; 3BUX; 3C1X; 3CCN; 3CD8; 3CE3; 3CTH; 3CTJ; 3DKC; 3DKF; 3DKG; 3EFJ; 3EFK; 3F66; 3F82; 3I5N; 3L8V; 3LQ8; 3Q6U; 3Q6W; 3QTI; 3R7O; 3RHK; 3U6H; 3U6I; 3VW8; 3ZBX; 3ZC5; 3ZCL; 3ZXZ; 3ZZE; 4AOI; 4AP7; 4DEG; 4DEH; 4DEI; 4EEV; 4GG5; 4GG7; 4IWD; 4K3J; 4KNB; 4MXC; 4O3T; 4O3U; 4R1V; 4R1Y; 4XMO; 4XYF	27.8%
2	ALK	Q9UM73	ALK tyrosine kinase receptor	hsa05200; hsa05223	2KUP; 2KUQ; 2XB7; 2XBA; 2XP2; 2YFX; 2YHV; 2YJR; 2YJS; 2YS5; 2YT2; 3AOX; 3L9P; 3LCS; 3LCT; 4ANL; 4ANQ; 4ANS; 4CCB; 4CCU; 4CD0; 4CLI; 4CLJ; 4CMO; 4CMT; 4CMU; 4CNH; 4CTB; 4CTC; 4DCE; 4FNW; 4FNX; 4FNY; 4FNZ; 4FOB; 4FOC; 4FOD; 4JOA; 4MKC; 4TT7	25.8%
3	EPHB4	P54760	Ephrin type-B receptor 4	hsa04360	2BBA; 2E7H; 2HLE; 2QKQ; 2VWU; 2VWV; 2VWW; 2VWX; 2VWY; 2VWZ; 2VX0; 2VX1; 2X9F; 2XVD; 2YN8; 3ZEW; 4AW5; 4BB4	21.9%
4	ROCK2	O75116	Rho-associated protein kinase 2	hsa04022; hsa04024; hsa04062; hsa04071; hsa04270; hsa04310; hsa04360; hsa04510; hsa04530; hsa04611; hsa04670; hsa04810; hsa04921; hsa05130; hsa05131; hsa05132; hsa05163; hsa05200; hsa05205	4L6Q; 4WOT	20.9%
5	PDGFRA	P16234	Platelet-derived growth factor receptor alpha	hsa01521; hsa04010; hsa04014; hsa04015; hsa04020; hsa04072; hsa04144; hsa04151; hsa04510; hsa04540; hsa04630; hsa04810; hsa05163; hsa05166; hsa05200; hsa05206; hsa05214; hsa05215; hsa05218; hsa05230; hsa05231	1GQ5	19.8%
6	BACE1	P56817	Beta-secretase 1	hsa05010	1FKN; 1M4H; 1PY1; 1SGZ; 1TQF; 1UJJ; 1UJK; 1W50; 1W51; 1XN2; 1XN3; 1XS7; 1YM2; 1YM4; 2B8L; 2B8V; 2F3E; 2F3F; 2FDP; 2G94; 2HIZ; 2HM1; 2IQG; 2IRZ; 2IS0; 2NTR; 2OAH; 2OF0; 2OHK; 2OHL; 2OHM; 2OHN; 2OHP; 2OHQ; 2OHR; 2OHS; 2OHT; 2OHU; 2P4J; 2P83; 2P8H; 2PH6; 2PH8; 2Q11; 2Q15; 2QK5; 2QMD; 2QMF; 2QMG; 2QP8; 2QU2; 2QU3; 2QZK; 2QZL; 2VA5; 2VA6; 2VA7; 2VIE; 2VIJ; 2VIY; 2VIZ; 2VJ6; 2VJ7; 2VJ9; 2VKM; 2VNM; 2VNN; 2WEZ; 2WF0; 2WF1; 2WF2; 2WF3; 2WF4; 2WJO; 2XFI; 2XFJ; 2XFK; 2ZDZ; 2ZE1; 2ZHR; 2ZHS; 2ZHT; 2ZHU; 2ZHV; 2ZJH; 2ZJI; 2ZJJ; 2ZJK; 2ZJL; 2ZJM; 2ZJN; 3BRA; 3BUF; 3BUG; 3BUH; 3CIB; 3CIC; 3CID; 3CKP; 3CKR; 3DM6; 3DUY; 3DV1; 3DV5; 3EXO; 3FKT; 3H0B; 3HVG; 3HW1; 3I25; 3IGB; 3IN3; 3IN4; 3IND; 3INE; 3INF; 3INH; 3IVH; 3IVI; 3IXJ; 3IXK; 3K5C; 3K5D; 3K5F; 3K5G; 3KMX; 3KMY; 3KN0; 3KYR; 3L38; 3L3A; 3L58; 3L59; 3L5B; 3L5C; 3L5D; 3L5E; 3L5F; 3LHG; 3LNK; 3LPI; 3LPJ; 3LPK; 3MSJ; 3MSK; 3MSL; 3N4L; 3NSH; 3OHF; 3OHH; 3OOZ; 3PI5; 3QBH; 3QI1; 3R1G; 3R2F; 3RSV; 3RSX; 3RTH; 3RTM; 3RTN; 3RU1; 3RVI; 3S2O; 3S7L; 3S7M; 3SKF; 3SKG; 3TPJ; 3TPL; 3TPP; 3TPR; 3U6A; 3UDH; 3UDJ; 3UDK; 3UDM; 3UDN; 3UDP; 3UDQ; 3UDR; 3UDY; 3UFL; 3UQP; 3UQR; 3UQU; 3UQW; 3UQX; 3VEU; 3VF3; 3VG1; 3VV6; 3VV7; 3VV8; 3WB4; 3WB5; 3ZMG; 3ZOV; 4ACU; 4ACX; 4AZY; 4B00; 4B05; 4B0Q; 4B1C; 4B1D; 4B1E; 4B70; 4B72; 4B77; 4B78; 4BEK; 4BFD; 4D83; 4D85; 4D88; 4D89; 4D8C; 4DH6; 4DI2; 4DJU; 4DJV; 4DJW; 4DJX; 4DJY; 4DPF; 4DPI; 4DUS; 4DV9; 4DVF; 4EWO; 4EXG; 4FCO; 4FGX; 4FM7; 4FM8; 4FRI; 4FRJ; 4FRK; 4FRS; 4FS4; 4FSE; 4FSL; 4GID; 4GMI; 4H1E; 4H3F; 4H3G; 4H3I; 4H3J; 4HA5; 4HZT; 4I0D; 4I0E; 4I0F; 4I0G; 4I0H; 4I0I; 4I0J; 4I0Z; 4I10; 4I11; 4I12; 4I1C; 4IVS; 4IVT; 4J0P; 4J0T; 4J0V; 4J0Y; 4J0Z; 4J17; 4J1C; 4J1E; 4J1F; 4J1H; 4J1I; 4J1K; 4JOO; 4JP9; 4JPC; 4JPE; 4K8S; 4K9H; 4KE0; 4KE1; 4L7G; 4L7H; 4L7J; 4LC7; 4LXA; 4LXK; 4LXM; 4N00; 4PZW; 4PZX; 4R5N; 4R8Y; 4R91; 4R92; 4R93; 4R95; 4RCD; 4RCE; 4RCF; 4RRN; 4RRO; 4RRS; 4TRW; 4TRY; 4TRZ; 4WTU; 4WY1; 4WY6; 4X2L; 4X7I; 4XKX; 4XXS; 4YBI; 4ZPE; 4ZPF; 4ZPG; 4ZSM; 4ZSP; 4ZSQ; 4ZSR; 5CLM	19.4%
7	SLC12A2	P55011	Solute carrier family 12 member 2	hsa04970; hsa04972; hsa05110	NA	19.3%
8	INSR	P06213	Insulin receptor	hsa04010; hsa04014; hsa04015; hsa04022; hsa04066; hsa04068; hsa04072; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04520; hsa04910; hsa04913; hsa04923; hsa04930; hsa04931; hsa04932; hsa04960	1GAG; 1I44; 1IR3; 1IRK; 1P14; 1RQQ; 2AUH; 2B4S; 2DTG; 2HR7; 2MFR; 2Z8C; 3BU3; 3BU5; 3BU6; 3EKK; 3EKN; 3ETA; 3LOH; 3W11; 3W12; 3W13; 3W14; 4IBM; 4OGA; 4XLV; 4XSS; 4XST; 5E1S	18.5%
9	OPRM1	P35372	Mu-type opioid receptor	hsa04080; hsa04915; hsa05032	NA	18.2%
10	SLC12A1	Q13621	Solute carrier family 12 member 1	NA	NA	17.7%
11	CTSL	P07711	Cathepsin L1	hsa04140; hsa04142; hsa04145; hsa04210; hsa04612; hsa05205; hsa05323; hsa05418	1CJL; 1CS8; 1ICF; 1MHW; 2NQD; 2VHS; 2XU1; 2XU3; 2XU4; 2XU5; 2YJ2; 2YJ8; 2YJ9; 2YJB; 2YJC; 3BC3; 3H89; 3H8B; 3H8C; 3HHA; 3HWN; 3IV2; 3K24; 3KSE; 3OF8; 3OF9; 4AXL; 4AXM	17.6%
12	SRC	P12931	Proto-oncogene tyrosine-protein kinase Src	hsa01521; hsa01522; hsa04012; hsa04015; hsa04062; hsa04137; hsa04144; hsa04360; hsa04370; hsa04510; hsa04520; hsa04530; hsa04540; hsa04611; hsa04625; hsa04727; hsa04750; hsa04810; hsa04912; hsa04915; hsa04917; hsa04919; hsa04921; hsa04926; hsa05100; hsa05120; hsa05131; hsa05152; hsa05161; hsa05163; hsa05167; hsa05203; hsa05205; hsa05219; hsa05418	1A07; 1A08; 1A09; 1A1A; 1A1B; 1A1C; 1A1E; 1FMK; 1HCS; 1HCT; 1KSW; 1O41; 1O42; 1O43; 1O44; 1O45; 1O46; 1O47; 1O48; 1O49; 1O4A; 1O4B; 1O4C; 1O4D; 1O4E; 1O4F; 1O4G; 1O4H; 1O4I; 1O4J; 1O4K; 1O4L; 1O4M; 1O4N; 1O4O; 1O4P; 1O4Q; 1O4R; 1SHD; 1Y57; 1YI6; 1YOJ; 1YOL; 1YOM; 2BDF; 2BDJ; 2H8H; 2SRC; 3VRO; 3ZMP; 3ZMQ; 4F59; 4F5A; 4F5B; 4HXJ; 4K11; 4MXO; 4MXX; 4MXY; 4MXZ	17.5%
13	FLT3	P36888	Receptor-type tyrosine-protein kinase FLT3	hsa04010; hsa04014; hsa04151; hsa04640; hsa05200; hsa05202; hsa05221; hsa05230	1RJB; 3QS7; 3QS9; 4RT7; 4XUF	17.4%
14	IKBKB	O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	hsa01523; hsa04010; hsa04014; hsa04062; hsa04064; hsa04068; hsa04150; hsa04151; hsa04210; hsa04380; hsa04620; hsa04621; hsa04622; hsa04623; hsa04625; hsa04657; hsa04658; hsa04659; hsa04660; hsa04662; hsa04668; hsa04722; hsa04910; hsa04920; hsa04930; hsa04931; hsa04932; hsa05120; hsa05131; hsa05142; hsa05145; hsa05160; hsa05161; hsa05163; hsa05164; hsa05165; hsa05166; hsa05167; hsa05168; hsa05169; hsa05170; hsa05200; hsa05206; hsa05212; hsa05215; hsa05220; hsa05221; hsa05222; hsa05418	3BRT; 3BRV; 4E3C; 4KIK	17.0%
15	IL1B	P01584	Interleukin-1 beta	hsa01523; hsa04010; hsa04060; hsa04064; hsa04217; hsa04380; hsa04620; hsa04621; hsa04623; hsa04625; hsa04640; hsa04657; hsa04659; hsa04668; hsa04750; hsa04932; hsa04933; hsa04940; hsa05010; hsa05020; hsa05132; hsa05133; hsa05134; hsa05140; hsa05142; hsa05143; hsa05144; hsa05146; hsa05152; hsa05162; hsa05163; hsa05164; hsa05168; hsa05321; hsa05323; hsa05332; hsa05418	1HIB; 1I1B; 1IOB; 1ITB; 1L2H; 1S0L; 1T4Q; 1TOO; 1TP0; 1TWE; 1TWM; 21BI; 2I1B; 2KH2; 2NVH; 31BI; 3LTQ; 3O4O; 3POK; 41BI; 4DEP; 4G6J; 4G6M; 4GAF; 4GAI; 4I1B; 5BVP; 5I1B; 6I1B; 7I1B; 9ILB	16.9%
16	AURKA	O14965	Aurora kinase A	hsa04114; hsa04914	1MQ4; 1MUO; 1OL5; 1OL6; 1OL7; 2BMC; 2C6D; 2C6E; 2DWB; 2J4Z; 2J50; 2NP8; 2W1C; 2W1D; 2W1E; 2W1F; 2W1G; 2WQE; 2WTV; 2WTW; 2X6D; 2X6E; 2X81; 2XNE; 2XNG; 2XRU; 3COH; 3E5A; 3EFW; 3FDN; 3H0Y; 3H0Z; 3H10; 3HA6; 3K5U; 3LAU; 3M11; 3MYG; 3NRM; 3O50; 3O51; 3P9J; 3QBN; 3R21; 3R22; 3UNZ; 3UO4; 3UO5; 3UO6; 3UOD; 3UOH; 3UOJ; 3UOK; 3UOL; 3UP2; 3UP7; 3VAP; 3W10; 3W16; 3W18; 3W2C; 4B0G; 4BN1; 4BYI; 4BYJ; 4C3P; 4C3R; 4CEG; 4DEA; 4DEB; 4DED; 4DEE; 4DHF; 4J8M; 4J8N; 4JAI; 4JAJ; 4JBO; 4JBP; 4JBQ; 4O0S; 4O0U; 4O0W; 4PRJ; 4UTD; 4UYN; 4UZD; 4UZH; 5AAD; 5AAE; 5AAF; 5AAG	16.7%
17	ACHE	P22303	Acetylcholinesterase	hsa00564; hsa04725	1B41; 1F8U; 1PUV; 1PUW; 1VZJ; 2CLJ; 2X8B; 3LII; 4BDT; 4EY4; 4EY5; 4EY6; 4EY7; 4EY8; 4M0E; 4M0F; 4PQE	16.1%
18	IGF1R	P08069	Insulin-like growth factor 1 receptor	hsa01521; hsa01522; hsa04010; hsa04014; hsa04015; hsa04066; hsa04068; hsa04114; hsa04140; hsa04144; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04510; hsa04520; hsa04550; hsa04730; hsa04913; hsa04914; hsa05200; hsa05202; hsa05205; hsa05214; hsa05215; hsa05218; hsa05224; hsa05225	1IGR; 1JQH; 1K3A; 1M7N; 1P4O; 2OJ9; 2ZM3; 3D94; 3F5P; 3I81; 3LVP; 3LW0; 3NW5; 3NW6; 3NW7; 3O23; 3QQU; 4D2R; 4XSS	15.7%
19	FGFR2	P21802	Fibroblast growth factor receptor 2	hsa01521; hsa04010; hsa04014; hsa04015; hsa04144; hsa04151; hsa04550; hsa04810; hsa05200; hsa05215; hsa05226; hsa05230	1DJS; 1E0O; 1EV2; 1GJO; 1II4; 1IIL; 1NUN; 1OEC; 1WVZ; 2FDB; 2PSQ; 2PVF; 2PVY; 2PWL; 2PY3; 2PZ5; 2PZP; 2PZR; 2Q0B; 3B2T; 3CAF; 3CLY; 3CU1; 3DAR; 3EUU; 3OJ2; 3OJM; 3RI1; 4J23; 4J95; 4J96; 4J97; 4J98; 4J99; 4WV1	15.7%
20	RIOK3	O14730	Serine/threonine-protein kinase RIO3	NA	NA	15.6%