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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB00799
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB00799 Tazarotene Thumb


4 known interactions (targets) of input drug (DB00799): Tazarotene
No. Gene UniProt ID Protein Name Pathway PDB
1 RARB P10826 Retinoic acid receptor beta hsa05200; hsa05222; hsa05223; hsa05226 1HRA; 1XAP; 4DM6; 4DM8; 4JYG; 4JYH; 4JYI
2 RXRB P28702 Retinoic acid receptor RXR-beta hsa03320; hsa04659; hsa04919; hsa04920; hsa04928; hsa05200; hsa05202; hsa05216; hsa05222; hsa05223; hsa05226 1H9U; 1UHL
3 RARA P10276 Retinoic acid receptor alpha hsa04659; hsa04915; hsa05200; hsa05202; hsa05221 1DKF; 1DSZ; 3A9E; 3KMR; 3KMZ; 4DQM
4 RARG P13631 Retinoic acid receptor gamma NA 1EXA; 1EXX; 1FCX; 1FCY; 1FCZ; 1FD0; 2LBD; 3LBD; 4LBD


20 predicted interactions (targets) of input drug (DB00799): Tazarotene
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 RXRG P48443 Retinoic acid receptor RXR-gamma hsa03320; hsa04659; hsa04919; hsa04920; hsa04928; hsa05200; hsa05202; hsa05216; hsa05222; hsa05223; hsa05226 2GL8 55.2%
2 RXRA P19793 Retinoic acid receptor RXR-alpha hsa03320; hsa04151; hsa04659; hsa04919; hsa04920; hsa04928; hsa04932; hsa04976; hsa05160; hsa05200; hsa05202; hsa05216; hsa05222; hsa05223; hsa05226 40.3%
3 CYP26C1 Q6V0L0 Cytochrome P450 26C1 hsa00830; hsa01100 NA 31.4%
4 RBP1 P09455 Retinol-binding protein 1 NA NA 26.3%
5 IGFBP3 P17936 Insulin-like growth factor-binding protein 3 hsa04115; hsa04218; hsa05202 NA 26.0%
6 NQO1 P15559 NAD(P)H dehydrogenase [quinone] 1 hsa00130; hsa05200; hsa05225; hsa05418 1D4A; 1DXO; 1GG5; 1H66; 1H69; 1KBO; 1KBQ; 1QBG; 2F1O; 3JSX; 4CET; 4CF6 25.8%
7 PSG5 Q15238 Pregnancy-specific beta-1-glycoprotein 5 NA NA 25.8%
8 AMY2B P19961 Alpha-amylase 2B hsa00500; hsa01100; hsa04972; hsa04973 NA 24.5%
9 JUN P05412 Transcription factor AP-1 hsa01522; hsa04010; hsa04012; hsa04024; hsa04137; hsa04210; hsa04310; hsa04380; hsa04510; hsa04530; hsa04620; hsa04621; hsa04625; hsa04657; hsa04658; hsa04659; hsa04660; hsa04662; hsa04668; hsa04722; hsa04912; hsa04915; hsa04921; hsa04926; hsa04932; hsa04933; hsa05030; hsa05031; hsa05120; hsa05132; hsa05133; hsa05140; hsa05142; hsa05161; hsa05164; hsa05166; hsa05167; hsa05168; hsa05169; hsa05170; hsa05200; hsa05203; hsa05210; hsa05211; hsa05224; hsa05231; hsa05321; hsa05323; hsa05418 1A02; 1FOS; 1JNM; 1JUN; 1S9K; 1T2K 19.7%
10 COMT P21964 Catechol O-methyltransferase hsa00140; hsa00350; hsa01100; hsa04728 3A7E; 3BWM; 3BWY; 4PYI; 4PYJ; 4PYK; 4XUC; 4XUD; 4XUE 17.8%
11 HPGDS O60760 Hematopoietic prostaglandin D synthase hsa00480; hsa00590; hsa00980; hsa00982; hsa01100; hsa05204 17.8%
12 ALDH1A1 P00352 Retinal dehydrogenase 1 hsa00830; hsa01100 4WB9; 4WJ9; 4WP7; 4WPN; 4X4L; 5AC2 17.8%
13 PTPN1 P18031 Tyrosine-protein phosphatase non-receptor type 1 hsa04520; hsa04910; hsa04931 17.4%
14 ALDH1A2 O94788 Retinal dehydrogenase 2 hsa00830; hsa01100 NA 17.3%
15 GPRC5A Q8NFJ5 Retinoic acid-induced protein 3 NA NA 17.2%
16 AHR P35869 Aryl hydrocarbon receptor hsa04659; hsa04934 NA 17.1%
17 NR1I3 Q14994 Nuclear receptor subfamily 1 group I member 3 NA 1XV9; 1XVP 16.9%
18 MIF P14174 Macrophage migration inhibitory factor hsa00350; hsa00360 16.8%
19 PDK4 Q16654 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial NA 2E0A; 2ZDX; 2ZDY; 2ZKJ; 3D2R 16.3%
20 ADORA2B P29275 Adenosine receptor A2b hsa04015; hsa04020; hsa04080; hsa04270; hsa05034 NA 15.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.