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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB00071
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
1 Approved BiotechDrug DB00071 Insulin Pork Thumb

14 known interactions (targets) of input drug (DB00071): Insulin Pork
No. Gene UniProt ID Protein Name Pathway PDB
1 IDE P14735 Insulin-degrading enzyme hsa05010
2 CPE P16870 Carboxypeptidase E hsa04940 NA
3 INSR P06213 Insulin receptor hsa04010; hsa04014; hsa04015; hsa04022; hsa04066; hsa04068; hsa04072; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04520; hsa04910; hsa04913; hsa04923; hsa04930; hsa04931; hsa04932; hsa04960
4 CTSD P07339 Cathepsin D hsa04071; hsa04140; hsa04142; hsa04210; hsa04915; hsa05152 1LYA; 1LYB; 1LYW; 4OBZ; 4OC6; 4OD9
5 LRP2 P98164 Low-density lipoprotein receptor-related protein 2 hsa04340; hsa04918; hsa04979 2M0P
6 IGF1R P08069 Insulin-like growth factor 1 receptor hsa01521; hsa01522; hsa04010; hsa04014; hsa04015; hsa04066; hsa04068; hsa04114; hsa04140; hsa04144; hsa04150; hsa04151; hsa04152; hsa04211; hsa04213; hsa04510; hsa04520; hsa04550; hsa04730; hsa04913; hsa04914; hsa05200; hsa05202; hsa05205; hsa05214; hsa05215; hsa05218; hsa05224; hsa05225 1IGR; 1JQH; 1K3A; 1M7N; 1P4O; 2OJ9; 2ZM3; 3D94; 3F5P; 3I81; 3LVP; 3LW0; 3NW5; 3NW6; 3NW7; 3O23; 3QQU; 4D2R; 4XSS
7 SYTL4 Q96C24 Synaptotagmin-like protein 4 NA 2CSZ; 3FDW
8 PCSK2 P16519 Neuroendocrine convertase 2 NA NA
9 HLA-DQA2 P01906 HLA class II histocompatibility antigen, DQ alpha 2 chain hsa04145; hsa04514; hsa04612; hsa04640; hsa04658; hsa04659; hsa04672; hsa04940; hsa05140; hsa05145; hsa05150; hsa05152; hsa05164; hsa05166; hsa05168; hsa05169; hsa05310; hsa05320; hsa05321; hsa05322; hsa05323; hsa05330; hsa05332; hsa05416 NA
10 RB1 P06400 Retinoblastoma-associated protein hsa01522; hsa04110; hsa04218; hsa04934; hsa05161; hsa05163; hsa05165; hsa05166; hsa05167; hsa05169; hsa05200; hsa05203; hsa05212; hsa05214; hsa05215; hsa05218; hsa05219; hsa05220; hsa05222; hsa05223; hsa05224; hsa05225; hsa05226 1AD6; 1GH6; 1GUX; 1H25; 1N4M; 1O9K; 1PJM; 2AZE; 2QDJ; 2R7G; 3N5U; 3POM; 4CRI; 4ELJ; 4ELL
11 HLA-DQB1 P01920 HLA class II histocompatibility antigen, DQ beta 1 chain hsa04145; hsa04514; hsa04612; hsa04640; hsa04658; hsa04659; hsa04672; hsa04940; hsa05140; hsa05145; hsa05150; hsa05152; hsa05164; hsa05166; hsa05168; hsa05169; hsa05310; hsa05320; hsa05321; hsa05322; hsa05323; hsa05330; hsa05332; hsa05416 1JK8; 1NBN; 1S9V; 1UVQ; 2NNA; 4GG6; 4OZF; 4OZG; 4OZH; 4OZI
12 NOV P48745 Protein NOV homolog NA NA
13 IGFBP7 Q16270 Insulin-like growth factor-binding protein 7 NA NA
14 PCSK1 P29120 Neuroendocrine convertase 1 NA NA

20 predicted interactions (targets) of input drug (DB00071): Insulin Pork
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 NOS2 P35228 Nitric oxide synthase, inducible hsa00220; hsa00330; hsa01100; hsa04020; hsa04066; hsa04146; hsa04371; hsa04926; hsa05132; hsa05133; hsa05140; hsa05142; hsa05145; hsa05146; hsa05152; hsa05200; hsa05222 1NSI; 2LL6; 2NSI; 3E7G; 3EJ8; 3HR4; 4CX7; 4NOS 31.4%
2 DHODH Q02127 Dihydroorotate dehydrogenase (quinone), mitochondrial hsa00240; hsa01100 26.7%
3 NOS3 P29474 Nitric oxide synthase, endothelial hsa00220; hsa00330; hsa01100; hsa04020; hsa04022; hsa04066; hsa04071; hsa04151; hsa04370; hsa04371; hsa04611; hsa04915; hsa04921; hsa04926; hsa04931; hsa04933; hsa05418 1M9J; 1M9K; 1M9M; 1M9Q; 1M9R; 1NIW; 2LL7; 2MG5; 3EAH; 3NOS; 4D1O; 4D1P 25.9%
4 TH P07101 Tyrosine 3-monooxygenase hsa00350; hsa00790; hsa01100; hsa04728; hsa04917; hsa05012; hsa05030; hsa05031; hsa05034 2XSN; 4J6S 25.8%
5 CACNA1C Q13936 Voltage-dependent L-type calcium channel subunit alpha-1C hsa04010; hsa04020; hsa04022; hsa04024; hsa04260; hsa04261; hsa04270; hsa04713; hsa04720; hsa04723; hsa04724; hsa04725; hsa04726; hsa04727; hsa04728; hsa04742; hsa04911; hsa04912; hsa04921; hsa04924; hsa04925; hsa04927; hsa04930; hsa04934; hsa05010; hsa05031; hsa05410; hsa05412; hsa05414 1T0J; 2BE6; 2F3Y; 2F3Z; 2LQC; 3G43; 3OXQ 25.5%
6 AR P10275 Androgen receptor hsa04114; hsa05200; hsa05215 24.5%
7 SLC12A3 P55017 Solute carrier family 12 member 3 NA NA 23.7%
8 HMOX2 P30519 Heme oxygenase 2 hsa00860; hsa01100; hsa04978 2Q32; 2QPP; 2RGZ; 4WMH 22.5%
9 PDE5A O76074 cGMP-specific 3',5'-cyclic phosphodiesterase hsa00230; hsa04022 22.1%
10 MTHFD1 P11586 C-1-tetrahydrofolate synthase, cytoplasmic hsa00670; hsa01100 1A4I; 1DIA; 1DIB; 1DIG 21.9%
11 F10 P00742 Coagulation factor X hsa04610
1C5M; 1EZQ; 1F0R; 1F0S; 1FAX; 1FJS; 1FXY; 1G2L; 1G2M; 1HCG; 1IOE; 1IQE; 1IQF; 1IQG; 1IQH; 1IQI; 1IQJ; 1IQK; 1IQL; 1IQM; 1IQN; 1KSN; 1LPG; 1LPK; 1LPZ; 1LQD; 1MQ5; 1MQ6; 1MSX; 1NFU; 1NFW; 1NFX; 1NFY; 1NL8; 1P0S; 1V3X; 1WU1; 1XKA; 1XKB; 1Z6E; 2BMG; 2BOH; 2BOK; 2BQ6; 2BQ7; 2BQW; 2CJI; 2D1J; 2EI6; 2EI7; 2EI8; 2FZZ; 2G00; 2GD4; 2H9E; 2J2U; 2J34; 2J38; 2J4I; 2J94; 2J95; 2JKH; 2P16; 2P3F; 2P3T; 2P3U; 2P93; 2P94; 2P95; 2PHB; 2PR3; 2Q1J; 2RA0; 2UWL; 2UWO; 2UWP; 2VH0; 2VH6; 2VVC; 2VVU; 2VVV; 2VWL; 2VWM; 2VWN; 2VWO; 2W26; 2W3I; 2W3K; 2WYG; 2WYJ; 2XBV; 2XBW; 2XBX; 2XBY; 2XC0; 2XC4; 2XC5; 2Y5F; 2Y5G; 2Y5H; 2Y7X; 2Y7Z; 2Y80; 2Y81; 2Y82; 3CEN; 3CS7; 3ENS; 3FFG; 3HPT; 3IIT; 3K9X; 3KL6; 3KQB; 3KQC; 3KQD; 3KQE; 3LIW; 3M36; 3M37; 3Q3K; 3SW2; 3TK5; 3TK6; 4A7I; 4BTI; 4BTT; 4BTU; 4Y6D; 4Y71; 4Y76; 4Y79; 4Y7A; 4Y7B
12 LTB4R Q15722 Leukotriene B4 receptor 1 hsa04080 NA 21.6%
13 DHFR P00374 Dihydrofolate reductase hsa00670; hsa00790; hsa01100; hsa01523 21.0%
14 HSPA8 P11142 Heat shock cognate 71 kDa protein hsa03040; hsa04010; hsa04141; hsa04144; hsa04213; hsa04612; hsa04915; hsa05134; hsa05145; hsa05162; hsa05164; hsa05169 3AGY; 3AGZ; 3ESK; 3FZF; 3FZH; 3FZK; 3FZL; 3FZM; 3LDQ; 3M3Z; 4H5N; 4H5R; 4H5T; 4H5V; 4H5W; 4HWI; 4KBQ 20.3%
15 G6PD P11413 Glucose-6-phosphate 1-dehydrogenase hsa00030; hsa00480; hsa01100; hsa01200; hsa05230 1QKI; 2BH9; 2BHL 20.1%
16 ANXA1 P04083 Annexin A1 NA 1AIN; 1BO9; 1QLS 19.8%
17 NR3C2 P08235 Mineralocorticoid receptor hsa04960 1Y9R; 1YA3; 2A3I; 2AA2; 2AA5; 2AA6; 2AA7; 2AAX; 2AB2; 2ABI; 2OAX; 3VHU; 3VHV; 3WFF; 3WFG; 4PF3; 4TNT 19.5%
18 HSD17B2 P37059 Estradiol 17-beta-dehydrogenase 2 hsa00140; hsa01100; hsa04913 NA 19.5%
19 HSD11B1 P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 hsa00140; hsa00980; hsa01100; hsa05204 19.4%
20 FARS2 O95363 Phenylalanine--tRNA ligase, mitochondrial hsa00970 3CMQ; 3HFV; 3TEG; 3TUP 19.3%


Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.


The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.