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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB06202
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational		 SmallMoleculeDrug DB06202 Lasofoxifene Thumb


3 known interactions (targets) of input drug (DB06202): Lasofoxifene
No. Gene UniProt ID Protein Name Pathway PDB
1 ESR1 P03372 Estrogen receptor hsa01522; hsa04915; hsa04917; hsa04919; hsa04961; hsa05200; hsa05205; hsa05224
2 CNR2 P34972 Cannabinoid receptor 2 hsa04080 2KI9
3 ESR2 Q92731 Estrogen receptor beta hsa01522; hsa04915; hsa04917; hsa05200; hsa05224


20 predicted interactions (targets) of input drug (DB06202): Lasofoxifene
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 CNR1 P21554 Cannabinoid receptor 1 hsa04015; hsa04080; hsa04714; hsa04723 1LVQ; 1LVR; 2B0Y; 2KOE 35.9%
2 NCOA2 Q15596 Nuclear receptor coactivator 2 hsa04915; hsa04919 30.6%
3 AR P10275 Androgen receptor hsa04114; hsa05200; hsa05215 27.7%
4 TRPV3 Q8NET8 Transient receptor potential cation channel subfamily V member 3 hsa04750 NA 26.9%
5 TRPA1 O75762 Transient receptor potential cation channel subfamily A member 1 hsa04750 3J9P 26.3%
6 SHBG P04278 Sex hormone-binding globulin NA 1D2S; 1F5F; 1KDK; 1KDM; 1LHN; 1LHO; 1LHU; 1LHV; 1LHW 26.0%
7 CACNA1H O95180 Voltage-dependent T-type calcium channel subunit alpha-1H hsa04010; hsa04020; hsa04713; hsa04925; hsa04927; hsa04934 NA 23.7%
8 TRPV2 Q9Y5S1 Transient receptor potential cation channel subfamily V member 2 hsa04621; hsa04750 2F37 23.5%
9 TRPV1 Q8NER1 Transient receptor potential cation channel subfamily V member 1 hsa04080; hsa04750 NA 23.2%
10 GPR55 Q9Y2T6 G-protein coupled receptor 55 NA NA 22.6%
11 CACNA1G O43497 Voltage-dependent T-type calcium channel subunit alpha-1G hsa04010; hsa04020; hsa04713; hsa04925; hsa04927; hsa04930; hsa04934 NA 22.5%
12 TRPM8 Q7Z2W7 Transient receptor potential cation channel subfamily M member 8 hsa04750 NA 21.2%
13 GPR18 Q14330 N-arachidonyl glycine receptor NA NA 21.2%
14 NCOA1 Q15788 Nuclear receptor coactivator 1 hsa04915; hsa04919; hsa05200; hsa05224 20.9%
15 GLRA1 P23415 Glycine receptor subunit alpha-1 hsa04080 1MOT; 1VRY; 2M6B; 2M6I; 4X5T 20.9%
16 PGR P06401 Progesterone receptor hsa04114; hsa04914; hsa04915; hsa05224 1A28; 1E3K; 1SQN; 1SR7; 1ZUC; 2C7A; 2OVH; 2OVM; 2W8Y; 3D90; 3G8O; 3HQ5; 3KBA; 3ZR7; 3ZRA; 3ZRB; 4A2J; 4APU; 4OAR 20.0%
17 GLRA3 O75311 Glycine receptor subunit alpha-3 hsa04080 5CFB 19.7%
18 GLRB P48167 Glycine receptor subunit beta hsa04080 NA 19.6%
19 NR1I2 O75469 Nuclear receptor subfamily 1 group I member 2 NA 18.9%
20 MT-ATP6 P00846 ATP synthase subunit a hsa00190; hsa01100; hsa04714; hsa05010; hsa05012; hsa05016 NA 18.2%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.