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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB11755
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter
Image
1 Investigational SmallMoleculeDrug DB11755 Tetrahydrocannabivarin Thumb


7 known interactions (targets) of input drug (DB11755): Tetrahydrocannabivarin
No. Gene UniProt ID Protein Name Pathway PDB
1 TRPA1 O75762 Transient receptor potential cation channel subfamily A member 1 hsa04750 3J9P
2 CNR1 P21554 Cannabinoid receptor 1 hsa04015; hsa04080; hsa04714; hsa04723 1LVQ; 1LVR; 2B0Y; 2KOE
3 TRPM8 Q7Z2W7 Transient receptor potential cation channel subfamily M member 8 hsa04750 NA
4 TRPV2 Q9Y5S1 Transient receptor potential cation channel subfamily V member 2 hsa04621; hsa04750 2F37
5 CNR2 P34972 Cannabinoid receptor 2 hsa04080 2KI9
6 GPR55 Q9Y2T6 G-protein coupled receptor 55 NA NA
7 HTR1A P08908 5-hydroxytryptamine receptor 1A hsa04024; hsa04080; hsa04726; hsa04742 NA


20 predicted interactions (targets) of input drug (DB11755): Tetrahydrocannabivarin
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 HTR2A P28223 5-hydroxytryptamine receptor 2A hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 NA 67.6%
2 TRPV3 Q8NET8 Transient receptor potential cation channel subfamily V member 3 hsa04750 NA 59.5%
3 TRPV1 Q8NER1 Transient receptor potential cation channel subfamily V member 1 hsa04080; hsa04750 NA 55.5%
4 DRD2 P14416 D(2) dopamine receptor hsa04015; hsa04024; hsa04080; hsa04540; hsa04728; hsa05012; hsa05030; hsa05034 1I15; 5AER 54.2%
5 HTR2C P28335 5-hydroxytryptamine receptor 2C hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 NA 52.8%
6 DRD3 P35462 D(3) dopamine receptor hsa04080; hsa04728 3PBL 52.3%
7 TRPV4 Q9HBA0 Transient receptor potential cation channel subfamily V member 4 hsa04218; hsa04750; hsa05418 4DX1; 4DX2 49.6%
8 HTR2B P41595 5-hydroxytryptamine receptor 2B hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 4IB4; 4NC3 48.1%
9 ADRA2B P18089 Alpha-2B adrenergic receptor hsa04022; hsa04080 2CVA 48.1%
10 CACNA1H O95180 Voltage-dependent T-type calcium channel subunit alpha-1H hsa04010; hsa04020; hsa04713; hsa04925; hsa04927; hsa04934 NA 48.1%
11 VDAC1 P21796 Voltage-dependent anion-selective channel protein 1 hsa04020; hsa04022; hsa04217; hsa04218; hsa04621; hsa04979; hsa05012; hsa05016; hsa05164; hsa05166 2JK4; 2K4T 47.7%
12 GLRB P48167 Glycine receptor subunit beta hsa04080 NA 47.4%
13 GPR12 P47775 G-protein coupled receptor 12 NA NA 46.9%
14 GPR18 Q14330 N-arachidonyl glycine receptor NA NA 46.1%
15 CACNA1G O43497 Voltage-dependent T-type calcium channel subunit alpha-1G hsa04010; hsa04020; hsa04713; hsa04925; hsa04927; hsa04930; hsa04934 NA 45.7%
16 HTR1B P28222 5-hydroxytryptamine receptor 1B hsa04024; hsa04080; hsa04726; hsa04742 2G1X; 4IAQ; 4IAR 45.2%
17 DRD5 P21918 D(1B) dopamine receptor hsa04020; hsa04024; hsa04080; hsa04728 NA 45.2%
18 CACNA1I Q9P0X4 Voltage-dependent T-type calcium channel subunit alpha-1I hsa04010; hsa04020; hsa04713; hsa04925; hsa04927; hsa04934 NA 45.1%
19 HTR7 P34969 5-hydroxytryptamine receptor 7 hsa04014; hsa04020; hsa04080; hsa04726 NA 43.3%
20 HTR1D P28221 5-hydroxytryptamine receptor 1D hsa04024; hsa04080; hsa04726; hsa04742 NA 42.9%



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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.