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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB00142
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Nutraceutical		 SmallMoleculeDrug DB00142 Glutamic Acid Thumb


70 known interactions (targets) of input drug (DB00142): Glutamic Acid
No. Gene UniProt ID Protein Name Pathway PDB
1 GLUD1 P00367 Glutamate dehydrogenase 1, mitochondrial hsa00220; hsa00250; hsa00471; hsa00910; hsa01100; hsa01200; hsa04217; hsa04964 1L1F; 1NR1
2 ENPEP Q07075 Glutamyl aminopeptidase hsa04614 4KX7; 4KX8; 4KX9; 4KXA; 4KXB; 4KXC; 4KXD
3 GAD2 Q05329 Glutamate decarboxylase 2 hsa00250; hsa00410; hsa00430; hsa00650; hsa01100; hsa04727; hsa04940 1ES0; 2OKK
4 GRIK5 Q16478 Glutamate receptor ionotropic, kainate 5 hsa04080; hsa04724 NA
5 GLS O94925 Glutaminase kidney isoform, mitochondrial hsa00220; hsa00250; hsa00471; hsa01100; hsa04724; hsa04727; hsa04964; hsa05206; hsa05230 3CZD; 3UNW; 3UO9; 3VOY; 3VOZ; 3VP0; 3VP1; 3VP2; 3VP3; 3VP4; 4O7D; 5D3O
6 GPT2 Q8TD30 Alanine aminotransferase 2 hsa00220; hsa00250; hsa01100; hsa01200; hsa01210; hsa01230 3IHJ
7 GOT1 P17174 Aspartate aminotransferase, cytoplasmic hsa00220; hsa00250; hsa00270; hsa00330; hsa00350; hsa00360; hsa00400; hsa01100; hsa01200; hsa01210; hsa01230 3II0; 3WZF
8 GLS2 Q9UI32 Glutaminase liver isoform, mitochondrial hsa00220; hsa00250; hsa00471; hsa01100; hsa04724; hsa04727; hsa04964; hsa05206; hsa05230 4BQM
9 SLC1A6 P48664 Excitatory amino acid transporter 4 hsa04724 NA
10 GRIK1 P39086 Glutamate receptor ionotropic, kainate 1 hsa04080; hsa04724 2ZNS; 2ZNT; 2ZNU; 3FUZ; 3FV1; 3FV2; 3FVG; 3FVK; 3FVN; 3FVO; 4MF3
11 GIG18 Q2TU84 Aspartate aminotransferase NA NA
12 ASNS P08243 Asparagine synthetase [glutamine-hydrolyzing] hsa00250; hsa01100; hsa01230 NA
13 DNPEP Q9ULA0 Aspartyl aminopeptidase NA 4DYO
14 GATB O75879 Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial hsa00970; hsa01100 NA
15 GAD1 Q99259 Glutamate decarboxylase 1 hsa00250; hsa00410; hsa00430; hsa00650; hsa01100; hsa04727; hsa04940 2OKJ; 3VP6
16 SLC1A2 P43004 Excitatory amino acid transporter 2 hsa04724; hsa05014 NA
17 GRIN3A Q8TCU5 Glutamate receptor ionotropic, NMDA 3A hsa04024; hsa04080; hsa04724; hsa05030; hsa05031; hsa05033; hsa05034 NA
18 SLC1A7 O00341 Excitatory amino acid transporter 5 hsa04724 NA
19 GRIN2C Q14957 Glutamate receptor ionotropic, NMDA 2C hsa04020; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa05010; hsa05014; hsa05030; hsa05031; hsa05033; hsa05034 NA
20 BCAT1 P54687 Branched-chain-amino-acid aminotransferase, cytosolic hsa00270; hsa00280; hsa00290; hsa00770; hsa01100; hsa01210; hsa01230 2ABJ; 2COG; 2COI; 2COJ
21 BCAT2 O15382 Branched-chain-amino-acid aminotransferase, mitochondrial hsa00270; hsa00280; hsa00290; hsa00770; hsa01100; hsa01210; hsa01230 1EKF; 1EKP; 1EKV; 1KT8; 1KTA; 2A1H; 2HDK; 2HG8; 2HGW; 2HGX; 2HHF; 5BWR; 5BWT; 5BWU; 5BWV; 5BWW; 5BWX; 5CR5
22 LGSN Q5TDP6 Lengsin NA NA
23 GRM7 Q14831 Metabotropic glutamate receptor 7 hsa04072; hsa04080; hsa04724 3MQ4; 5C5C
24 FPGS Q05932 Folylpolyglutamate synthase, mitochondrial hsa00790; hsa01100; hsa01523 NA
25 GRID2 O43424 Glutamate receptor ionotropic, delta-2 hsa04080; hsa04730 NA
26 NAGS Q8N159 N-acetylglutamate synthase, mitochondrial hsa00220; hsa01100; hsa01210; hsa01230 4K30
27 GCLC P48506 Glutamate--cysteine ligase catalytic subunit hsa00270; hsa00480; hsa01100; hsa04216 NA
28 AADAT Q8N5Z0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial hsa00310; hsa00380; hsa01100; hsa01210 2QLR; 2R2N; 2VGZ; 2XH1; 3DC1; 3UE8; 4GDY; 4GE4; 4GE7; 4GE9; 4GEB; 5EFS
29 TAT P17735 Tyrosine aminotransferase hsa00130; hsa00270; hsa00350; hsa00360; hsa00400; hsa01100; hsa01230 3DYD
30 CCBL2 Q6YP21 Kynurenine--oxoglutarate transaminase 3 hsa00380; hsa00450; hsa01100; hsa05204 NA
31 SLC25A22 Q9H936 Mitochondrial glutamate carrier 1 NA NA
32 CPQ Q9Y646 Carboxypeptidase Q NA NA
33 SLC7A11 Q9UPY5 Cystine/glutamate transporter hsa04216 NA
34 GRIA4 P48058 Glutamate receptor 4 hsa04024; hsa04080; hsa04713; hsa04723; hsa04724; hsa04728; hsa05031; hsa05033 NA
35 GRIK4 Q16099 Glutamate receptor ionotropic, kainate 4 hsa04080; hsa04724 NA
36 GRIA3 P42263 Glutamate receptor 3 hsa04024; hsa04080; hsa04713; hsa04723; hsa04724; hsa04728; hsa04730; hsa05031; hsa05033; hsa05202 NA
37 NADSYN1 Q6IA69 Glutamine-dependent NAD(+) synthetase hsa00760; hsa01100 NA
38 GRIN2A Q12879 Glutamate receptor ionotropic, NMDA 2A hsa04014; hsa04015; hsa04020; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa04728; hsa05010; hsa05014; hsa05030; hsa05031; hsa05033; hsa05034; hsa05322 3NFL
39 PFAS O15067 Phosphoribosylformylglycinamidine synthase hsa00230; hsa01100 NA
40 GPT P24298 Alanine aminotransferase 1 hsa00220; hsa00250; hsa01100; hsa01200; hsa01210; hsa01230 NA
41 SLC1A1 P43005 Excitatory amino acid transporter 3 hsa04724; hsa04974 NA
42 FOLH1 Q04609 Glutamate carboxypeptidase 2 hsa00250; hsa01100; hsa04977
43 SLC1A3 P43003 Excitatory amino acid transporter 1 hsa04724 NA
44 EARS2 Q5JPH6 Probable glutamate--tRNA ligase, mitochondrial hsa00860; hsa00970; hsa01100 NA
45 GRIA1 P42261 Glutamate receptor 1 hsa04024; hsa04080; hsa04713; hsa04720; hsa04723; hsa04724; hsa04728; hsa04730; hsa05014; hsa05031; hsa05033 NA
46 ALDH18A1 P54886 Delta-1-pyrroline-5-carboxylate synthase hsa00330; hsa01100; hsa01230 2H5G
47 GRM4 Q14833 Metabotropic glutamate receptor 4 hsa04072; hsa04080; hsa04724; hsa04742 NA
48 GOT2 P00505 Aspartate aminotransferase, mitochondrial hsa00220; hsa00250; hsa00270; hsa00330; hsa00350; hsa00360; hsa00400; hsa01100; hsa01200; hsa01210; hsa01230; hsa04975 NA
49 GRIN2D O15399 Glutamate receptor ionotropic, NMDA 2D hsa04020; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa05010; hsa05014; hsa05030; hsa05031; hsa05033; hsa05034 NA
50 GRM8 O00222 Metabotropic glutamate receptor 8 hsa04072; hsa04080; hsa04724 NA
51 PSAT1 Q9Y617 Phosphoserine aminotransferase hsa00260; hsa00750; hsa01100; hsa01200; hsa01230 3E77
52 GLUD2 P49448 Glutamate dehydrogenase 2, mitochondrial hsa00220; hsa00250; hsa00471; hsa00910; hsa01100; hsa01200; hsa04217; hsa04964 NA
53 GMPS P49915 GMP synthase [glutamine-hydrolyzing] hsa00230; hsa00983; hsa01100 2VPI; 2VXO
54 EPRS P07814 Bifunctional glutamate/proline--tRNA ligase hsa00860; hsa00970; hsa01100 1FYJ; 4HVC; 4K86; 4K87; 4K88; 5A34; 5BMU
55 GRIK2 Q13002 Glutamate receptor ionotropic, kainate 2 hsa04080; hsa04724 3QXM
56 GRIN3B O60391 Glutamate receptor ionotropic, NMDA 3B hsa04024; hsa04080; hsa04724; hsa05030; hsa05031; hsa05033; hsa05034 NA
57 GRID1 Q9ULK0 Glutamate receptor ionotropic, delta-1 hsa04080 NA
58 SLC25A18 Q9H1K4 Mitochondrial glutamate carrier 2 NA NA
59 ABAT P80404 4-aminobutyrate aminotransferase, mitochondrial hsa00250; hsa00280; hsa00410; hsa00640; hsa00650; hsa01100; hsa04727 NA
60 GRIN1 Q05586 Glutamate receptor ionotropic, NMDA 1 hsa04014; hsa04015; hsa04020; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa05010; hsa05014; hsa05016; hsa05030; hsa05031; hsa05033; hsa05034 2HQW; 2NR1; 3BYA
61 GCLM P48507 Glutamate--cysteine ligase regulatory subunit hsa00270; hsa00480; hsa01100; hsa04216 NA
62 GRIK3 Q13003 Glutamate receptor ionotropic, kainate 3 hsa04080; hsa04724 NA
63 GRIA2 P42262 Glutamate receptor 2 hsa04024; hsa04080; hsa04713; hsa04720; hsa04723; hsa04724; hsa04728; hsa04730; hsa05014; hsa05030; hsa05031; hsa05033 2WJW; 2WJX; 2XHD; 3R7X; 3RN8; 3RNN; 3UA8
64 OPLAH O14841 5-oxoprolinase hsa00480; hsa01100 NA
65 GRM1 Q13255 Metabotropic glutamate receptor 1 hsa04020; hsa04068; hsa04072; hsa04080; hsa04540; hsa04720; hsa04723; hsa04724; hsa04730; hsa04742; hsa04915 3KS9; 4OR2
66 GGCX P38435 Vitamin K-dependent gamma-carboxylase hsa00130 NA
67 GLUL P15104 Glutamine synthetase hsa00220; hsa00250; hsa00630; hsa00910; hsa01100; hsa01230; hsa04217; hsa04724; hsa04727 2OJW; 2QC8
68 FTCD O95954 Formimidoyltransferase-cyclodeaminase hsa00340; hsa00670; hsa01100 NA
69 AASS Q9UDR5 Alpha-aminoadipic semialdehyde synthase, mitochondrial hsa00310; hsa01100 NA
70 GRIN2B Q13224 Glutamate receptor ionotropic, NMDA 2B hsa04014; hsa04015; hsa04024; hsa04080; hsa04713; hsa04720; hsa04724; hsa04728; hsa05010; hsa05014; hsa05016; hsa05030; hsa05031; hsa05033; hsa05034; hsa05322 1S11; 1S2S; 2IPV


20 predicted interactions (targets) of input drug (DB00142): Glutamic Acid
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 DHODH Q02127 Dihydroorotate dehydrogenase (quinone), mitochondrial hsa00240; hsa01100 49.0%
2 MAN1B1 Q9UKM7 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase hsa00510; hsa01100; hsa04141 1FMI; 1FO2; 1FO3; 1X9D 46.2%
3 KCNH2 Q12809 Potassium voltage-gated channel subfamily H member 2 NA 1BYW; 1UJL; 2L0W; 2L1M; 2L4R; 2LE7; 4HP9; 4HQA 46.2%
4 SLC7A7 Q9UM01 Y+L amino acid transporter 1 hsa04974 NA 44.0%
5 SLC7A3 Q8WY07 Cationic amino acid transporter 3 NA NA 42.5%
6 MMP3 P08254 Stromelysin-1 hsa04657; hsa04668; hsa05202; hsa05215; hsa05323 41.6%
7 ALDOB P05062 Fructose-bisphosphate aldolase B hsa00010; hsa00030; hsa00051; hsa01100; hsa01200; hsa01230 1QO5; 1XDL; 1XDM 40.4%
8 REN P00797 Renin hsa04614; hsa04924 38.1%
9 SCN1A P35498 Sodium channel protein type 1 subunit alpha hsa04728 NA 37.0%
10 ALDOA P04075 Fructose-bisphosphate aldolase A hsa00010; hsa00030; hsa00051; hsa01100; hsa01200; hsa01230; hsa04066 1ALD; 2ALD; 4ALD 35.8%
11 TYR P14679 Tyrosinase hsa00350; hsa01100; hsa04916 NA 35.4%
12 DHFRL1 Q86XF0 Dihydrofolate reductase, mitochondrial hsa00670; hsa00790; hsa01100; hsa01523 NA 35.0%
13 IMPDH2 P12268 Inosine-5'-monophosphate dehydrogenase 2 hsa00230; hsa00983; hsa01100 1B3O; 1NF7; 1NFB 34.7%
14 CHRNA7 Q693P7 Alpha-7 nicotinic cholinergic receptor subunit NA NA 34.2%
15 HTR3A P46098 5-hydroxytryptamine receptor 3A hsa04726; hsa04742 NA 33.8%
16 GAD65 Q9UGI5 Glutamic acid decarboxylase NA NA 33.6%
17 SHMT2 P34897 Serine hydroxymethyltransferase, mitochondrial hsa00260; hsa00630; hsa00670; hsa01100; hsa01200; hsa01230; hsa01523 3OU5; 4PVF 33.4%
18 ADSSL1 Q8N142 Adenylosuccinate synthetase isozyme 1 hsa00230; hsa00250; hsa01100 2GJO 33.1%
19 CCBL1 Q16773 Kynurenine--oxoglutarate transaminase 1 hsa00380; hsa00450; hsa01100; hsa05204 1W7L; 1W7M; 1W7N; 3FVS; 3FVU; 3FVX; 4WLH; 4WLJ; 4WP0 33.0%
20 NA Q59FK2 Selenocysteine lyase variant hsa00450; hsa01100 NA 32.9%


  logl

Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.