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Network of interactions between drugs (red spheres) and targets (blue spheres) is displayed above.
The red lines are used for the predicted interactions and the thickness of edges indicate the confidence score of predictions.

Data source: DrugBank-all; Query type: chemical; # of requested predictions: 20; Secondary interactions: no
Input drug 1: DB00114
No. Group Type Drug ID Drug Name SMILES
⇨ TargetHunter		 Image
1 Approved;
Investigational;
Nutraceutical		 SmallMoleculeDrug DB00114 Pyridoxal Phosphate Thumb


66 known interactions (targets) of input drug (DB00114): Pyridoxal Phosphate
No. Gene UniProt ID Protein Name Pathway PDB
1 AGXT2 Q9BYV1 Alanine--glyoxylate aminotransferase 2, mitochondrial hsa00250; hsa00260; hsa00270; hsa00280; hsa01100 NA
2 KYNU Q16719 Kynureninase hsa00380; hsa01100 2HZP; 3E9K
3 GAD65 Q9UGI5 Glutamic acid decarboxylase NA NA
4 GCAT O75600 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial hsa00260 NA
5 GOT1 P17174 Aspartate aminotransferase, cytoplasmic hsa00220; hsa00250; hsa00270; hsa00330; hsa00350; hsa00360; hsa00400; hsa01100; hsa01200; hsa01210; hsa01230 3II0; 3WZF
6 GPT2 Q8TD30 Alanine aminotransferase 2 hsa00220; hsa00250; hsa01100; hsa01200; hsa01210; hsa01230 3IHJ
7 GADL1 Q6ZQY3 Acidic amino acid decarboxylase GADL1 hsa00410; hsa00430; hsa00770; hsa01100 NA
8 DDC Q6IBS8 DDC protein NA NA
9 SHMT2 P34897 Serine hydroxymethyltransferase, mitochondrial hsa00260; hsa00630; hsa00670; hsa01100; hsa01200; hsa01230; hsa01523 3OU5; 4PVF
10 AZIN2 Q96A70 Antizyme inhibitor 2 hsa00330; hsa01100 NA
11 ALAS1 P13196 5-aminolevulinate synthase, nonspecific, mitochondrial hsa00260; hsa00860; hsa01100 NA
12 CBS P35520 Cystathionine beta-synthase NA 1JBQ; 1M54; 4COO; 4L0D; 4L27; 4L28; 4L3V; 4PCU; 4UUU
13 GIG18 Q2TU84 Aspartate aminotransferase NA NA
14 SRR Q9GZT4 Serine racemase hsa00260; hsa01100 3L6B; 3L6R
15 PDXP Q96GD0 Pyridoxal phosphate phosphatase hsa00750; hsa01100 2CFR; 2CFS; 2CFT; 2OYC; 2P27; 2P69
16 NFS1 Q9Y697 Cysteine desulfurase, mitochondrial hsa00730; hsa01100; hsa04122 NA
17 CSAD Q9Y600 Cysteine sulfinic acid decarboxylase hsa00430; hsa01100 2JIS
18 GAD1 Q99259 Glutamate decarboxylase 1 hsa00250; hsa00410; hsa00430; hsa00650; hsa01100; hsa04727; hsa04940 2OKJ; 3VP6
19 IGSF10 Q6WRI0 Immunoglobulin superfamily member 10 NA NA
20 pcap Q96JQ3 P-selectin cytoplasmic tail-associated protein (PCAP) hsa00430; hsa01100 NA
21 SPTLC1 O15269 Serine palmitoyltransferase 1 hsa00600; hsa01100; hsa04071 NA
22 AGXT P21549 Serine--pyruvate aminotransferase hsa00250; hsa00260; hsa00630; hsa01100; hsa01200; hsa04146 1H0C; 1J04; 2YOB; 3R9A; 4CBR; 4CBS; 4I8A; 4KXK; 4KYO
23 BCAT1 P54687 Branched-chain-amino-acid aminotransferase, cytosolic hsa00270; hsa00280; hsa00290; hsa00770; hsa01100; hsa01210; hsa01230 2ABJ; 2COG; 2COI; 2COJ
24 PROSC O94903 Proline synthase co-transcribed bacterial homolog protein NA NA
25 CCBL1 Q16773 Kynurenine--oxoglutarate transaminase 1 hsa00380; hsa00450; hsa01100; hsa05204 1W7L; 1W7M; 1W7N; 3FVS; 3FVU; 3FVX; 4WLH; 4WLJ; 4WP0
26 BCAT2 O15382 Branched-chain-amino-acid aminotransferase, mitochondrial hsa00270; hsa00280; hsa00290; hsa00770; hsa01100; hsa01210; hsa01230 1EKF; 1EKP; 1EKV; 1KT8; 1KTA; 2A1H; 2HDK; 2HG8; 2HGW; 2HGX; 2HHF; 5BWR; 5BWT; 5BWU; 5BWV; 5BWW; 5BWX; 5CR5
27 PNPO Q9NVS9 Pyridoxine-5'-phosphate oxidase hsa00750; hsa01100 1NRG; 3HY8
28 GAD2 Q5VZ30 Glutamate decarboxylase 2 (Pancreatic islets and brain, 65kDa) hsa00250; hsa00410; hsa00430; hsa00650; hsa01100; hsa04727; hsa04940 NA
29 SPTLC3 Q9NUV7 Serine palmitoyltransferase 3 hsa00600; hsa01100; hsa04071 NA
30 SPTLC2 O15270 Serine palmitoyltransferase 2 hsa00600; hsa01100; hsa04071 NA
31 PDXDC1 Q6P996 Pyridoxal-dependent decarboxylase domain-containing protein 1 NA NA
32 AADAT Q8N5Z0 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial hsa00310; hsa00380; hsa01100; hsa01210 2QLR; 2R2N; 2VGZ; 2XH1; 3DC1; 3UE8; 4GDY; 4GE4; 4GE7; 4GE9; 4GEB; 5EFS
33 SGPL1 O95470 Sphingosine-1-phosphate lyase 1 hsa00600; hsa01100; hsa04071 4Q6R
34 GAD1 Q8IVA8 Glutamate decarboxylase 1 (Brain, 67kDa) hsa00250; hsa00410; hsa00430; hsa00650; hsa01100; hsa04727; hsa04940 NA
35 CCBL2 Q6YP21 Kynurenine--oxoglutarate transaminase 3 hsa00380; hsa00450; hsa01100; hsa05204 NA
36 HDC P19113 Histidine decarboxylase hsa00340; hsa01100 4E1O
37 NA Q9BXA1 Hepatic peroxysomal alanine:glyoxylate aminotransferase NA NA
38 GLDC P23378 Glycine dehydrogenase (decarboxylating), mitochondrial hsa00260; hsa00630; hsa01100; hsa01200 NA
39 NA Q59FK2 Selenocysteine lyase variant hsa00450; hsa01100 NA
40 DDC P20711 Aromatic-L-amino-acid decarboxylase hsa00350; hsa00360; hsa00380; hsa01100; hsa04726; hsa04728; hsa05030; hsa05031; hsa05034 3RBF; 3RBL; 3RCH
41 ALAS2 P22557 5-aminolevulinate synthase, erythroid-specific, mitochondrial hsa00260; hsa00860; hsa01100 NA
42 ODC1 P11926 Ornithine decarboxylase hsa00330; hsa00480; hsa01100 1D7K; 2ON3; 2OO0; 4ZGY
43 GPT P24298 Alanine aminotransferase 1 hsa00220; hsa00250; hsa01100; hsa01200; hsa01210; hsa01230 NA
44 ALAS1 Q5JAM2 5-aminolevulinate synthase hsa00260; hsa00860; hsa01100 NA
45 CTH P32929 Cystathionine gamma-lyase hsa00260; hsa00270; hsa00450; hsa01100; hsa01230 2NMP; 3COG; 3ELP
46 SEPSECS Q9HD40 O-phosphoseryl-tRNA(Sec) selenium transferase hsa00450; hsa00970 3HL2
47 SDSL Q96GA7 Serine dehydratase-like hsa00260; hsa00270; hsa00290; hsa01100; hsa01200; hsa01230 2RKB
48 SCLY Q96I15 Selenocysteine lyase hsa00450; hsa01100 3GZC; 3GZD
49 SHMT1 P34896 Serine hydroxymethyltransferase, cytosolic hsa00260; hsa00630; hsa00670; hsa01100; hsa01200; hsa01230; hsa01523 1BJ4
50 TAT P17735 Tyrosine aminotransferase hsa00130; hsa00270; hsa00350; hsa00360; hsa00400; hsa01100; hsa01230 3DYD
51 GOT2 P00505 Aspartate aminotransferase, mitochondrial hsa00220; hsa00250; hsa00270; hsa00330; hsa00350; hsa00360; hsa00400; hsa01100; hsa01200; hsa01210; hsa01230; hsa04975 NA
52 TLH6 Q9UJX1 Alanine-glyoxylate aminotransferase homolog NA NA
53 PSAT1 Q9Y617 Phosphoserine aminotransferase hsa00260; hsa00750; hsa01100; hsa01200; hsa01230 3E77
54 PYGB P11216 Glycogen phosphorylase, brain form hsa00500; hsa01100; hsa04217; hsa04910; hsa04922; hsa04931 NA
55 PHYKPL Q8IUZ5 5-phosphohydroxy-L-lysine phospho-lyase hsa00310; hsa01100 NA
56 PYGL P06737 Glycogen phosphorylase, liver form hsa00500; hsa01100; hsa04217; hsa04910; hsa04922; hsa04931 1EM6; 1EXV; 1FA9; 1FC0; 1L5Q; 1L5R; 1L5S; 1L7X; 1XOI; 2ATI; 2QLL; 2ZB2; 3CEH; 3CEJ; 3CEM; 3DD1; 3DDS; 3DDW
57 ABAT P80404 4-aminobutyrate aminotransferase, mitochondrial hsa00250; hsa00280; hsa00410; hsa00640; hsa00650; hsa01100; hsa04727 NA
58 SDS P20132 L-serine dehydratase/L-threonine deaminase hsa00260; hsa00270; hsa00290; hsa01100; hsa01200; hsa01230 1P5J; 4H27
59 NA Q59GM9 Alpha-1,4 glucan phosphorylase NA NA
60 NA Q59HE2 Ornithine aminotransferase variant NA NA
61 NA Q53ET4 Serine hydroxymethyltransferase NA NA
62 OAT P04181 Ornithine aminotransferase, mitochondrial hsa00330; hsa01100 1GBN; 1OAT; 2BYJ; 2BYL; 2CAN; 2OAT
63 THNSL1 Q8IYQ7 Threonine synthase-like 1 NA NA
64 PYGM P11217 Glycogen phosphorylase, muscle form hsa00500; hsa01100; hsa04217; hsa04910; hsa04922; hsa04931 1Z8D
65 MOCOS Q96EN8 Molybdenum cofactor sulfurase hsa00790 NA
66 FTCD O95954 Formimidoyltransferase-cyclodeaminase hsa00340; hsa00670; hsa01100 NA


20 predicted interactions (targets) of input drug (DB00114): Pyridoxal Phosphate
No. Gene UniProt ID Protein Name Pathway PDB Confidence score
1 HTR2A P28223 5-hydroxytryptamine receptor 2A hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 NA 54.4%
2 HTR2C P28335 5-hydroxytryptamine receptor 2C hsa04020; hsa04080; hsa04540; hsa04726; hsa04750 NA 49.0%
3 SLC36A1 Q7Z2H8 Proton-coupled amino acid transporter 1 hsa04974 NA 45.1%
4 AMD1 P17707 S-adenosylmethionine decarboxylase proenzyme hsa00270; hsa00330; hsa01100 43.4%
5 PTGS1 P23219 Prostaglandin G/H synthase 1 hsa00590; hsa01100; hsa04611; hsa04726; hsa04923 NA 42.3%
6 PNMT P11086 Phenylethanolamine N-methyltransferase hsa00350; hsa01100 41.4%
7 SLC7A8 Q9UHI5 Large neutral amino acids transporter small subunit 2 hsa04974 NA 41.4%
8 HSP90B1 P14625 Endoplasmin hsa04141; hsa04151; hsa04657; hsa04915; hsa04918; hsa05200; hsa05215; hsa05418 4NH9 40.1%
9 HTR6 P50406 5-hydroxytryptamine receptor 6 hsa04020; hsa04024; hsa04080; hsa04726 NA 39.7%
10 PTGS2 P35354 Prostaglandin G/H synthase 2 hsa00590; hsa01100; hsa04064; hsa04370; hsa04625; hsa04657; hsa04668; hsa04723; hsa04726; hsa04913; hsa04921; hsa04923; hsa05140; hsa05163; hsa05165; hsa05167; hsa05200; hsa05204; hsa05206; hsa05222 1V0X 39.1%
11 VKORC1 Q9BQB6 Vitamin K epoxide reductase complex subunit 1 hsa00130 NA 38.2%
12 HTR7 P34969 5-hydroxytryptamine receptor 7 hsa04014; hsa04020; hsa04080; hsa04726 NA 37.4%
13 AARS2 Q5JTZ9 Alanine--tRNA ligase, mitochondrial hsa00970 NA 36.7%
14 PLA2G2E Q9NZK7 Group IIE secretory phospholipase A2 hsa00564; hsa00565; hsa00590; hsa00591; hsa00592; hsa01100; hsa04014; hsa04270; hsa04972; hsa04975 NA 35.8%
15 NQO1 P15559 NAD(P)H dehydrogenase [quinone] 1 hsa00130; hsa05200; hsa05225; hsa05418 1D4A; 1DXO; 1GG5; 1H66; 1H69; 1KBO; 1KBQ; 1QBG; 2F1O; 3JSX; 4CET; 4CF6 35.6%
16 GCLC P48506 Glutamate--cysteine ligase catalytic subunit hsa00270; hsa00480; hsa01100; hsa04216 NA 35.5%
17 RARG P13631 Retinoic acid receptor gamma NA 1EXA; 1EXX; 1FCX; 1FCY; 1FCZ; 1FD0; 2LBD; 3LBD; 4LBD 35.0%
18 FPGS Q05932 Folylpolyglutamate synthase, mitochondrial hsa00790; hsa01100; hsa01523 NA 34.8%
19 SLC6A3 Q01959 Sodium-dependent dopamine transporter hsa04728; hsa05012; hsa05030; hsa05031; hsa05034 NA 34.8%
20 HTR1B P28222 5-hydroxytryptamine receptor 1B hsa04024; hsa04080; hsa04726; hsa04742 2G1X; 4IAQ; 4IAR 34.3%


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Reference:  Hongchun Li, Fen Pei, D. Lansing Taylor and Ivet Bahar. (2020) QuartataWeb: Integrated Chemical–Protein-Pathway Mapping for Polypharmacology and Chemogenomics. Bioinformatics 36(12), 3935–3937.

Contact:

The QuartataWeb server is maintained by the Bahar Lab at the Department of Computational & Systems Biology at the University of Pittsburgh, School of Medicine, and sponsored by the NIH awards P41 GM103712 and P01 DK096990; and by the Li Lab at Research Center for Computer-Aided Drug Discovery at Shenzhen Institutes of Advanced Technology, CAS.

For questions and comments please contact Hongchun Li.