QuartataWeb 1.0

2 known interactions (targets) of input drug (DB00731): Nateglinide

No.	Gene	UniProt ID	Protein Name	Pathway	PDB
1	PPARG	P37231	Peroxisome proliferator-activated receptor gamma	hsa03320; hsa04152; hsa04211; hsa04380; hsa04714; hsa05016; hsa05200; hsa05202; hsa05216	1FM6; 1FM9; 1I7I; 1K74; 1KNU; 1NYX; 1PRG; 1RDT; 1WM0; 1ZEO; 1ZGY; 2ATH; 2F4B; 2FVJ; 2G0G; 2G0H; 2GTK; 2HFP; 2HWQ; 2HWR; 2I4J; 2I4P; 2I4Z; 2OM9; 2P4Y; 2POB; 2PRG; 2Q59; 2Q5P; 2Q5S; 2Q61; 2Q6R; 2Q6S; 2Q8S; 2QMV; 2VSR; 2VST; 2VV0; 2VV1; 2VV2; 2VV3; 2VV4; 2XKW; 2YFE; 2ZK0; 2ZK1; 2ZK2; 2ZK3; 2ZK4; 2ZK5; 2ZK6; 2ZNO; 2ZVT; 3ADS; 3ADT; 3ADU; 3ADV; 3ADW; 3ADX; 3AN3; 3AN4; 3B0Q; 3B0R; 3B1M; 3B3K; 3BC5; 3CDP; 3CDS; 3CS8; 3CWD; 3D6D; 3DZU; 3DZY; 3E00; 3ET0; 3ET3; 3FEJ; 3FUR; 3G9E; 3GBK; 3H0A; 3HO0; 3HOD; 3IA6; 3K8S; 3KMG; 3LMP; 3NOA; 3OSI; 3OSW; 3PBA; 3PO9; 3PRG; 3QT0; 3R5N; 3R8A; 3R8I; 3S9S; 3SZ1; 3T03; 3TY0; 3U9Q; 3V9T; 3V9V; 3V9Y; 3VJH; 3VJI; 3VN2; 3VSO; 3VSP; 3WJ4; 3WJ5; 3WMH; 3X1H; 3X1I; 4A4V; 4A4W; 4CI5; 4E4K; 4E4Q; 4EM9; 4EMA; 4F9M; 4FGY; 4HEE; 4JAZ; 4JL4; 4L96; 4L98; 4O8F; 4OJ4; 4PRG; 4PVU; 4PWL; 4R2U; 4R6S; 4XLD; 4XTA; 4XUM; 4Y29
2	ABCC8	Q09428	ATP-binding cassette sub-family C member 8	hsa02010; hsa04911; hsa04930	NA

20 predicted interactions (targets) of input drug (DB00731): Nateglinide

No.	Gene	UniProt ID	Protein Name	Pathway	PDB	Confidence score
1	PPARA	Q07869	Peroxisome proliferator-activated receptor alpha	hsa03320; hsa04024; hsa04920; hsa04922; hsa04931; hsa04932; hsa05160	1I7G; 1K7L; 1KKQ; 2NPA; 2P54; 2REW; 2ZNN; 3ET1; 3FEI; 3G8I; 3KDT; 3KDU; 3SP6; 3VI8; 4BCR; 4CI4	34.9%
2	PPARD	Q03181	Peroxisome proliferator-activated receptor delta	hsa03320; hsa04310; hsa05200; hsa05221	1GWX; 1Y0S; 2AWH; 2B50; 2BAW; 2ENV; 2GWX; 2J14; 2Q5G; 2XYJ; 2XYW; 2XYX; 2ZNP; 2ZNQ; 3D5F; 3DY6; 3ET2; 3GWX; 3GZ9; 3OZ0; 3PEQ; 3SP9; 3TKM	24.3%
3	CFTR	P13569	Cystic fibrosis transmembrane conductance regulator	hsa02010; hsa04024; hsa04152; hsa04530; hsa04971; hsa04972; hsa04976; hsa05110	1NBD; 1XMI; 1XMJ; 2BBO; 2BBS; 2BBT; 2LOB; 2PZE; 2PZF; 2PZG; 3GD7; 3ISW	21.7%
4	KCNJ11	Q14654	ATP-sensitive inward rectifier potassium channel 11	hsa04911; hsa04930	NA	16.8%
5	KCNJ1	P48048	ATP-sensitive inward rectifier potassium channel 1	hsa04960; hsa04971	NA	16.2%
6	CHRM5	P08912	Muscarinic acetylcholine receptor M5	hsa04020; hsa04080; hsa04725; hsa04810	NA	15.6%
7	SREBF1	P36956	Sterol regulatory element-binding protein 1	hsa04152; hsa04910; hsa04931; hsa04932	1AM9	15.2%
8	THRB	P10828	Thyroid hormone receptor beta	hsa04080; hsa04919	1BSX; 1N46; 1NAX; 1NQ0; 1NQ1; 1NQ2; 1NUO; 1Q4X; 1R6G; 1XZX; 1Y0X; 2J4A; 2NLL; 2PIN; 3D57; 3GWS; 3IMY; 3JZC; 4ZO1	15.1%
9	BRAF	P15056	Serine/threonine-protein kinase B-raf	hsa01521; hsa01522; hsa04010; hsa04012; hsa04015; hsa04024; hsa04062; hsa04068; hsa04150; hsa04270; hsa04510; hsa04650; hsa04720; hsa04722; hsa04726; hsa04730; hsa04810; hsa04910; hsa04914; hsa04928; hsa04934; hsa05034; hsa05160; hsa05200; hsa05205; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05216; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223; hsa05224; hsa05225; hsa05226	1UWH; 1UWJ; 2FB8; 2L05; 3C4C; 3D4Q; 3IDP; 3II5; 3NY5; 3OG7; 3PPJ; 3PPK; 3PRF; 3PRI; 3PSB; 3PSD; 3Q4C; 3Q96; 3SKC; 3TV4; 3TV6; 4DBN; 4E26; 4E4X; 4EHE; 4EHG; 4FC0; 4FK3; 4G9C; 4G9R; 4H58; 4JVG; 4KSP; 4KSQ; 4MBJ; 4MNE; 4MNF; 4PP7; 4WO5; 4XV1; 4XV2; 4XV3; 4XV9; 5C9C; 5CT7	14.5%
10	DRD4	P21917	D(4) dopamine receptor	hsa04080; hsa04728	NA	14.2%
11	PLAT	P00750	Tissue-type plasminogen activator	hsa04371; hsa04610; hsa05202; hsa05215; hsa05418	1A5H; 1BDA; 1PK2; 1PML; 1RTF; 1TPG; 1TPK; 1TPM; 1TPN; 5BRR	14.0%
12	ALK	Q9UM73	ALK tyrosine kinase receptor	hsa05200; hsa05223	2KUP; 2KUQ; 2XB7; 2XBA; 2XP2; 2YFX; 2YHV; 2YJR; 2YJS; 2YS5; 2YT2; 3AOX; 3L9P; 3LCS; 3LCT; 4ANL; 4ANQ; 4ANS; 4CCB; 4CCU; 4CD0; 4CLI; 4CLJ; 4CMO; 4CMT; 4CMU; 4CNH; 4CTB; 4CTC; 4DCE; 4FNW; 4FNX; 4FNY; 4FNZ; 4FOB; 4FOC; 4FOD; 4JOA; 4MKC; 4TT7	13.9%
13	APP	P05067	Amyloid beta A4 protein	hsa04726; hsa05010	1AAP; 1AMB; 1AMC; 1AML; 1BA4; 1BA6; 1BJB; 1BJC; 1BRC; 1CA0; 1HZ3; 1IYT; 1MWP; 1OWT; 1QCM; 1QWP; 1QXC; 1QYT; 1TAW; 1TKN; 1UO7; 1UO8; 1UOA; 1UOI; 1X11; 1Z0Q; 1ZE7; 1ZE9; 1ZJD; 2BEG; 2BOM; 2BP4; 2FJZ; 2FK1; 2FK2; 2FK3; 2FKL; 2FMA; 2G47; 2IPU; 2LFM; 2LLM; 2LMN; 2LMO; 2LMP; 2LMQ; 2LNQ; 2LOH; 2LP1; 2LZ3; 2LZ4; 2M4J; 2M9R; 2M9S; 2MGT; 2MJ1; 2MPZ; 2MVX; 2MXU; 2OTK; 2R0W; 2WK3; 2Y29; 2Y2A; 2Y3J; 2Y3K; 2Y3L; 3AYU; 3BAE; 3BKJ; 3DXC; 3DXD; 3DXE; 3GCI; 3IFL; 3IFN; 3IFO; 3IFP; 3JQ5; 3JQL; 3JTI; 3KTM; 3L33; 3L81; 3MOQ; 3MXC; 3MXY; 3NYJ; 3NYL; 3OVJ; 3OW9; 3SV1; 3U0T; 3UMH; 3UMI; 3UMK; 4HIX; 4JFN; 4M1C; 4MDR; 4MVI; 4MVK; 4MVL; 4NGE; 4OJF; 4ONF; 4ONG; 4PQD; 4PWQ; 4XXD; 5AEF; 5CSZ	13.7%
14	NCOA1	Q15788	Nuclear receptor coactivator 1	hsa04915; hsa04919; hsa05200; hsa05224	1FM6; 1FM9; 1K4W; 1K74; 1K7L; 1KV6; 1N4H; 1NQ7; 1NRL; 1P8D; 1PZL; 1RDT; 1TFC; 1U3R; 1U3S; 1X76; 1X78; 1X7B; 1X7J; 1XIU; 1XV9; 1XVP; 1YY4; 1YYE; 1ZAF; 2A3I; 2C52; 2FVJ; 2GTK; 2HBH; 2HC4; 2HCD; 2HFP; 2NPA; 2NV7; 2P54; 2PRG; 3BEJ; 3BQD; 3CTB; 3CWD; 3DCT; 3DCU; 3DR1; 3ET1; 3ET3; 3FEI; 3FEJ; 3FUR; 3FXV; 3G8I; 3G9E; 3GYT; 3GYU; 3H0A; 3HC5; 3HC6; 3HVL; 3IPQ; 3IPS; 3IPU; 3KMR; 3LMP; 3OKH; 3OKI; 3OLF; 3OLL; 3OLS; 3OMK; 3OMM; 3OMO; 3OMP; 3OMQ; 3OOF; 3OOK; 3P88; 3P89; 3QT0; 3RUT; 3RUU; 3RVF; 3S9S; 3T03; 3UU7; 3UUA; 3UUD; 3V9Y; 3VN2; 4DK7; 4DK8; 4DM6; 4DM8; 4DQM; 4F9M; 4FGY; 4G1D; 4G1Y; 4G1Z; 4G20; 4G21; 4G2H; 4HEE; 4J5X; 4JYG; 4JYH; 4JYI; 4MG5; 4MG6; 4MG7; 4MG8; 4MG9; 4MGA; 4MGB; 4MGC; 4MGD; 4RUJ; 4RUP; 4TUZ; 4TV1; 4Y29; 5A86; 5AVI; 5AVL	13.6%
15	CBR1	P16152	Carbonyl reductase [NADPH] 1	hsa00590; hsa00790; hsa00980; hsa01100; hsa05204	1WMA; 2PFG; 3BHI; 3BHJ; 3BHM; 4Z3D	13.2%
16	CA2	P00918	Carbonic anhydrase 2	hsa00910; hsa04964; hsa04966; hsa04971; hsa04972; hsa04976	12CA; 1A42; 1AM6; 1AVN; 1BCD; 1BIC; 1BN1; 1BN3; 1BN4; 1BNM; 1BNN; 1BNQ; 1BNT; 1BNU; 1BNV; 1BNW; 1BV3; 1CA2; 1CA3; 1CAH; 1CAI; 1CAJ; 1CAK; 1CAL; 1CAM; 1CAN; 1CAO; 1CAY; 1CAZ; 1CCS; 1CCT; 1CCU; 1CIL; 1CIM; 1CIN; 1CNB; 1CNC; 1CNG; 1CNH; 1CNI; 1CNJ; 1CNK; 1CNW; 1CNX; 1CNY; 1CRA; 1CVA; 1CVB; 1CVC; 1CVD; 1CVE; 1CVF; 1CVH; 1DCA; 1DCB; 1EOU; 1F2W; 1FQL; 1FQM; 1FQN; 1FQR; 1FR4; 1FR7; 1FSN; 1FSQ; 1FSR; 1G0E; 1G0F; 1G1D; 1G3Z; 1G45; 1G46; 1G48; 1G4J; 1G4O; 1G52; 1G53; 1G54; 1H4N; 1H9N; 1H9Q; 1HCA; 1HEA; 1HEB; 1HEC; 1HED; 1HVA; 1I8Z; 1I90; 1I91; 1I9L; 1I9M; 1I9N; 1I9O; 1I9P; 1I9Q; 1IF4; 1IF5; 1IF6; 1IF7; 1IF8; 1IF9; 1KWQ; 1KWR; 1LG5; 1LG6; 1LGD; 1LUG; 1LZV; 1MOO; 1MUA; 1OKL; 1OKM; 1OKN; 1OQ5; 1RAY; 1RAZ; 1RZA; 1RZB; 1RZC; 1RZD; 1RZE; 1T9N; 1TB0; 1TBT; 1TE3; 1TEQ; 1TEU; 1TG3; 1TG9; 1TH9; 1THK; 1TTM; 1UGA; 1UGB; 1UGC; 1UGD; 1UGE; 1UGF; 1UGG; 1XEG; 1XEV; 1XPZ; 1XQ0; 1YDA; 1YDB; 1YDC; 1YDD; 1YO0; 1YO1; 1YO2; 1Z9Y; 1ZE8; 1ZFK; 1ZFQ; 1ZGE; 1ZGF; 1ZH9; 1ZSA; 1ZSB; 1ZSC; 2ABE; 2AW1; 2AX2; 2CA2; 2CBA; 2CBB; 2CBC; 2CBD; 2CBE; 2EU2; 2EU3; 2EZ7; 2F14; 2FMG; 2FMZ; 2FNK; 2FNM; 2FNN; 2FOQ; 2FOS; 2FOU; 2FOV; 2GD8; 2GEH; 2H15; 2H4N; 2HD6; 2HKK; 2HL4; 2HNC; 2HOC; 2ILI; 2NNG; 2NNO; 2NNS; 2NNV; 2NWO; 2NWP; 2NWY; 2NWZ; 2NXR; 2NXS; 2NXT; 2O4Z; 2OSF; 2OSM; 2POU; 2POV; 2POW; 2Q1B; 2Q1Q; 2Q38; 2QO8; 2QOA; 2QP6; 2VVA; 2VVB; 2WD2; 2WD3; 2WEG; 2WEH; 2WEJ; 2WEO; 2X7S; 2X7T; 2X7U; 3B4F; 3BET; 3BL0; 3BL1; 3C7P; 3CA2; 3CAJ; 3CYU; 3D8W; 3D92; 3D93; 3D9Z; 3DAZ; 3DBU; 3DC3; 3DC9; 3DCC; 3DCS; 3DCW; 3DD0; 3DD8; 3DV7; 3DVB; 3DVC; 3DVD; 3EFI; 3EFT; 3F4X; 3F8E; 3FFP; 3GZ0; 3HFP; 3HKN; 3HKQ; 3HKT; 3HKU; 3HLJ; 3HS4; 3IBI; 3IBL; 3IBN; 3IBU; 3IEO; 3IGP; 3K2F; 3K34; 3K7K; 3KIG; 3KKX; 3KNE; 3KOI; 3KOK; 3KON; 3KS3; 3KWA; 3L14; 3M04; 3M14; 3M1J; 3M1K; 3M1Q; 3M1W; 3M2N; 3M2X; 3M2Y; 3M2Z; 3M3X; 3M40; 3M5E; 3M5S; 3M5T; 3M67; 3M96; 3M98; 3MHC; 3MHI; 3MHL; 3MHM; 3MHO; 3ML2; 3MMF; 3MNA; 3MNH; 3MNI; 3MNJ; 3MNK; 3MNU; 3MWO; 3MYQ; 3MZC; 3N0N; 3N2P; 3N3J; 3N4B; 3NB5; 3NI5; 3NJ9; 3OIK; 3OIL; 3OIM; 3OKU; 3OKV; 3OY0; 3OYQ; 3OYS; 3P3H; 3P3J; 3P44; 3P4V; 3P55; 3P58; 3P5A; 3P5L; 3PJJ; 3PO6; 3PYK; 3QYK; 3R16; 3R17; 3RG3; 3RG4; 3RGE; 3RJ7; 3RLD; 3RYJ; 3RYV; 3RYX; 3RYY; 3RYZ; 3RZ0; 3RZ1; 3RZ5; 3RZ7; 3RZ8; 3S71; 3S72; 3S73; 3S74; 3S75; 3S76; 3S77; 3S78; 3S8X; 3S9T; 3SAP; 3SAX; 3SBH; 3SBI; 3T5U; 3T5Z; 3T82; 3T83; 3T84; 3T85; 3TMJ; 3TVN; 3TVO; 3U3A; 3U45; 3U47; 3U7C; 3V2J; 3V2M; 3V3F; 3V3G; 3V3H; 3V3I; 3V3J; 3V5G; 3V7X; 3VBD; 3ZP9; 4BCW; 4BF1; 4BF6; 4CA2; 4CAC; 4CQ0; 4DZ7; 4DZ9; 4E3D; 4E3F; 4E3G; 4E3H; 4E49; 4E4A; 4E5Q; 4FIK; 4FL7; 4FPT; 4FRC; 4FU5; 4FVN; 4FVO; 4G0C; 4GL1; 4HBA; 4HEW; 4HEY; 4HEZ; 4HF3; 4HT0; 4IDR; 4ILX; 4ITO; 4ITP; 4IWZ; 4JS6; 4JSA; 4JSS; 4JSW; 4JSZ; 4K0S; 4K0T; 4K0Z; 4K13; 4K1Q; 4KAP; 4KNI; 4KNJ; 4KUV; 4KUW; 4KUY; 4KV0; 4L5U; 4L5V; 4L5W; 4LHI; 4LP6; 4M2R; 4M2U; 4M2V; 4M2W; 4MDG; 4MDL; 4MDM; 4MLT; 4MLX; 4MO8; 4MTY; 4N0X; 4N16; 4PQ7; 4PXX; 4PYX; 4PYY; 4PZH; 4Q06; 4Q07; 4Q08; 4Q09; 4Q49; 4Q6D; 4Q6E; 4Q78; 4Q7P; 4Q7S; 4Q7V; 4Q7W; 4Q81; 4Q83; 4Q87; 4Q8X; 4Q8Y; 4Q8Z; 4Q90; 4Q99; 4Q9Y; 4QEF; 4QIY; 4QJM; 4QK1; 4QK2; 4QK3; 4QSA; 4QSB; 4QSI; 4QTL; 4QY3; 4R59; 4R5A; 4R5B; 4RFC; 4RFD; 4RH2; 4RIU; 4RIV; 4RN4; 4RUX; 4RUY; 4RUZ; 4WL4; 4WW6; 4XE1; 4Y0J; 4YGJ; 4YGK; 4YGL; 4YGN; 4YWP; 4Z0Q; 4Z1E; 4Z1J; 4Z1K; 4Z1N; 4ZAO; 4ZWI; 4ZWX; 4ZWY; 4ZWZ; 4ZX0; 4ZX1; 5AMD; 5AMG; 5AML; 5BNL; 5BRU; 5BRV; 5BRW; 5BYI; 5CA2; 5CAC; 5CLU; 5E2R; 6CA2; 7CA2; 8CA2; 9CA2	13.2%
17	CA1	P00915	Carbonic anhydrase 1	hsa00910	1AZM; 1BZM; 1CRM; 1CZM; 1HCB; 1HUG; 1HUH; 1J9W; 1JV0; 2CAB; 2FOY; 2FW4; 2IT4; 2NMX; 2NN1; 2NN7; 3LXE; 3W6H; 3W6I; 4WR7; 4WUP; 4WUQ	12.9%
18	ALOX5	P09917	Arachidonate 5-lipoxygenase	hsa00590; hsa01100; hsa04664; hsa04726; hsa04913; hsa05145	2ABV; 3O8Y; 3V92; 3V98; 3V99	12.9%
19	TYMS	P04818	Thymidylate synthase	hsa00240; hsa00670; hsa01100; hsa01523	1HVY; 1HW3; 1HW4; 1HZW; 1I00; 1JU6; 1JUJ; 1YPV; 2ONB; 2RD8; 2RDA; 3EAW; 3EBU; 3ED7; 3EDW; 3EF9; 3EGY; 3EHI; 3EJL; 3GG5; 3GH0; 3GH2; 3H9K; 3HB8; 3N5E; 3N5G; 3OB7; 4E28; 4FGT; 4G2O; 4G6W; 4GD7; 4GYH; 4H1I; 4JEF; 4KPW; 4O1U; 4O1X; 4UP1	12.4%
20	mmp20	O43923	Matrix metalloproteinase-25	NA	NA	12.3%